#ACR21 Hench Lecture. Wonderful talks by Peggy Crow on #lupus pathogenesis. Tour de force since LE cells discovery. Potential sources of self-nucleic acids: 💠Endogeneous retroelements LINE-1 💠Mitochondria 💠Cell-derived nuclear debris (NETs, apoptotic) @RheumNow https://t.co/TSdyqblYaA

Great Hench Lecture from Peggy Crow at HSS! From LE Cell to Interferon: Deconstructing Lupus Pathogenesis #ACR21 https://t.co/rUxiwKGFqm https://t.co/af2PKrFBv3

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Obesity does not affect #SLE disease activity despite persistent ⬆️in CRP. From Toronto #lupus database #ACR21 abst#0864 @RheumNow https://t.co/4ZpAMaU0jk

Attaining low disease activity in #SLE ⬇️ mortality! More time in LLDAS = #lupus low disease activity state = ⬆️survival in >4000 pts with SLE. Also + was clinical remission on treatment CROT. Treat to a target has come to SLE @RheumNow #ACR21 abst0865 #ACRBest #RheumPix https://t.co/8ld8oncFRR

Dr. P Crow #PhilipHench provides a tour of research on SLE pathogenesis: 👉discovery of Ab to small nuclear RNAs and the spliceosome 👉T cells' role on B cell differentiation 👉⬆️CD40L on SLE lymphocytes 👉IFN genes and their effects on the immune system #ACR21 @rheumnow https://t.co/6v9O19UUxX

Dr. P Crow #PhilipHenchLecture IFN signature can parallel or predict flares #ACR21 @rheumnow https://t.co/OskxDuKPDH

Soluble urinary ALCAM previously shown as potential biomarker for LN. Further study showing urinary ALCAM trended with changes in renal-SLEDAI and UPCr. #ACR21 Abst#3053 @RheumNow https://t.co/IqVJej7yda

• https://bit.ly/3qa2Eae

Important to discuss men with #lupus Nationwide claims study showed increased occurrence of multimorbidity in men with SLE compared to women with SLE #ACR21 @RheumNow @AliDuarteMD Abst#0579 #ACRBest https://t.co/ljflGU84Ro

Ear dyspigmentation, scalp dyspigmentation and scarring alopecia found more frequently in Black DLE pts. Findings may help assist in dx and tx plans. Abs 0598 #ACR21 #RheumNow #ACRbest @RheumNow https://t.co/a1pxWHJ7b5

• Differences in Discoid Lupus Erythematosus Skin Lesion Distribution and Charact…