New treatments in #psoriaticarthritis Deucravacitinib TYK2 inhibitor selectively mediates cytokine signaling, specific inflammatory pathways (eg, IL-23, IL-12, and Type I interferons) concomitant with clinical symptom improvement @RheumNow #ACR21 Abst#0490 https://t.co/7JZGa5R4eC

• Biomarker Changes with Selective Tyrosine Kinase 2 Inhibitor, Deucravacitinib, …

#ClinicalPearl What lasts longer/⬆️retention in sero+ RA: Abatacept or TNFi or JAKi? #ACR21 abst#0463 @RheumNow Adjusting for confounding incl line of Rx / past bio Rx, #abatacept wins. But data not stratified for bio naive or exposed. Not sure if that would alter results https://t.co/1dEQncwPQF

Retrospective French study found adding JAKi may be helpful in refractory AOSD. No complete response noted and no beneficial effect as monotherapy. Possible difference between JAKi? Abs 0195 #ACR21 #RheumNow #ACRbest @RheumNow https://t.co/J8kLJpJ39o https://t.co/aVsfCQ8CyV

• JAK Inhibitors in Refractory Adult and Childhood-Onset Still's Disease - A…

Gender differences in AS pts? IL-23R, IL-12R, IL-6R, JAK, STAT and TYK2 ⬇️regulated in men Small study of 20 pts, but could it guide targeted therapy based on gender?🤔 Abs#0050 https://t.co/OQHQCCzfuC #ACR21 @RheumNow

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Year in Review #ACR21. How do you feel about JAK inhibitor after one year of new studies and the new FDA warning? @Rheumnow

#ClinicalPearl #JAKi works in #ankylosingspondylitis (AS). Trial of #tofacitinib positive. Don’t confuse with jack ass! @YearinReview #ACR21 @RheumNow presented by Karen Costenbader https://t.co/2VvEMhiI8L