Sub-analysis of ICHIBAN study looking at adverse events in tocilizumab treated patients with/without steroids. Steroids associated with small increase in adverse events across board. Abstr#1693 #ACR21 @RheumNow https://t.co/ldiovirKpo

Meta-analysis of PUFA supplementation in RA. Apparent benefits across most measures, albeit often small. Abstr#1682 #ACR21 @RheumNow https://t.co/1rGhpqvJvp

GLORIA study of adding prednisolone 5mg to DMARDs over 2 years for RA in those >65 years. Mean DAS 0.37 points lower, Sharp score 1.7 lower (are either of these clinically significant?). NNH 9.5. To me causing harm chasing statistical benefit Abstr#1678 #ACR21 @RheumNow #ACRBest https://t.co/KYk1II3J3w

I don't know much about antifibrotics in RA-ILD, but these data emphasise that HRCT pattern matters My simple mind, for any disease: multiple subtypes with different trajectories➡️likely to be differing responses to Rx TRAIL1: pirfenidone in RA-ILD #ACR21 ABSTL10 @RheumNow https://t.co/v7HCO0ZBe1

Comparative effects of abatacept in RA-ILD with UIP/NSIP. Appears equally effective in stabilising FVC, DLCO, and HRCT findings in both. Abstr#1683 #ACR21 @RheumNow https://t.co/l0Ia1D9c56

Sleep disturbance common and associated with disease activity (both PRO and physician-assessed) in RA. Need further studies to evaluate causal directions, but may well be bidirectional? Abstr#1666 #ACR21 @RheumNow https://t.co/eK65I92wPg

#ACR21 Ab#1683: ABA for RA-ILD ⭐️Stabilization of DLCO, FVC, HRCT in UIP and NSIP in 106 UIP, 84 NSIP patients ⭐️Stabilization or improvement of dyspnea in 91% UIP, 95% NSIP pts @Rheumnow https://t.co/qfgDmooGOj https://t.co/gz6Jk15nUs

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#ACR21 Ab#1699: ITIS diet: ⭐️Fatigue ⬇️ in 20 pts on ITIS trial, didn't correlate with final DAS28CRP ⭐️Fatigue responders (50% improvement) had different fecal microbiome changes & anti-inflamm compounds, than non-responders @Rheumnow https://t.co/UvE2ZpxCDU

• https://bit.ly/3wv0wL9

☄️Late breakingTRAIL1 RCT Pirfenidone on RA-ILD. ✨Primary outcome on incidence of decline of >10% FVC or death not met 11% PIR vs. 15% PBO OR=0.67 p=0.48 BUT ✨underpowered ✨reduces decline in FVC(ml) over 52wk (-66 vs. -146, p=0.0082) ✨safety ok #ACR21 #AbstL10 @RheumNow https://t.co/IxYDE3lN1s

Safety update for #filgotinib in #RA over ~2.2yrs treatment 👉🏼Well-tolerated with no ne safety concerns since 2020 👉🏼AE incidence rates decreased or remained stable 👉🏼Slight incr rates of NMSC & non-NMSC malignancies Abs#1698 #ACR21 @RheumNow https://t.co/0jbZFVgiyN https://t.co/yOlntLwQlU

• Integrated Safety Analysis Update for Filgotinib in Patients with Moderately to…

#ACR21 Ab#1655. Respiratory Ifn in RA on bDMARD ▶️1 group was initiated into vaccination program vs usual care ⭐️Vaccinated group had ⬇️ admissions from respiratory ifns. 44% ⬇️ severe resp ifn 💉programs work! @Rheumnow https://t.co/pljR6DbAtU https://t.co/goSHGID8qG

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#Multimorbidity in women with #rheumatoidarthritis is increased compared to men with RA. However, women and men without RA have similar levels of multimorbidity. Abs#1656 #ACR21 @RheumNow https://t.co/iXhXOldTy0 https://t.co/CsOM7odE69

• Women with Rheumatoid Arthritis Have More Multimorbidity Than Men in a Large Na…

#ACR21 Ab#1658 - Autoimmune Risks in Relatives of RA pts. 1st degree relatives have risk of: ▶️ AI thyroid (OR 1.3) ▶️ Celiac (1.5) ▶️ SLE (1.3) ▶️ IBD - no ⬆️ risk ⭐️1st, 2nd, 3rd degree relativ: ⬆️ risk of RA ⭐️2nd degree: ⬆️ risk SLE https://t.co/ATHdemoF45 @Rheumnow #ACRbest https://t.co/JcuZmg9L8E

• https://bit.ly/3GZjEGd

GLORIA RCT: 400+ pts. Low dose Pred in RA >65yo on top of other treatments 2yrs. Authors conclude benefit/risk balance in favour of GCs 🧐 2 thoughts: 1️⃣ CV risk linked to GCs ⬆️ over time and cumulative dose: Follow up= short! 2️⃣ Small # for CV events #ACR21 #Abst 1678 @RheumNow https://t.co/QECJR68ZJu

What is the likelihood of developing an #autoimmunedisease in first-degree relatives of pts with #RA? Genealogical & phenotypic data suggests lower threshold for screening for autoimmune thyroiditis, #coeliac & #SLE in FDRs. Abs#1658 #ACR21 @RheumNow https://t.co/PdSZ05elsf https://t.co/AkIXDkWCM8

• Risk of Other Autoimmune Conditions Among Relatives of Patients with Rheumatoid…