Sleep Quality & Psoriatic Arthritis
For people living with psoriatic arthritis (PsA), the comfort of a good night's sleep may feel out of reach for many.
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Ultrasound in PsA
Dr. Arthur Kavanaugh discusses abstract 2206 presented at ACR22 in Philadelphia. Abstract 2206: Understanding Inter-rater Variability in Scoring of Entheseal Lesions: Results from the Diagnostic Ultrasound Enthesitis Tool (DUET) Study
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Tapering TNFi in nonradiographic AxSpA
Dr. Peter Nash at ACR22 Convergence in Philadelphia, PA.
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Sunday (Day 2): ACR 22 Daily Recap
ACR 2022 Daily Recap for Sunday, November 13th. Panelists: Drs. Robert Chao, Antoni Chan, Bella Mehta, Janet Pope, Yuz Yusof, Cassy Sims, Akhil Sood, Sheila Reyes and Jack Cush.
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Spondyloarthritis: Novel Therapies, Diagnostic Dilemmas and Depression
Dr. Lianne Gensler discusses the following abstracts presented at ACR22 Convergence. Abstracts 1597, 1598, 1599 (treatment) and 1613, 1609 and 1614 (diagnosis and outcomes)
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Deucravacitinib in PsA
Dr. Arthur Kavanaugh discusses abstract 1598 at ACR22 Convergence in Philadelphia. Abstract 1598: Safety and Efficacy of Deucravacitinib, an Oral, Selective Tyrosine Kinase 2 Inhibitor, in Patients with Psoriatic Arthritis: 52-Week Results from a Randomized Phase 2 Trial
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PET CT Imaging to Define Risk of Progression from PSO to PsA
Dr. Peter Nash discusses Abstract 1018 at ACR22 Convergence.
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ACR22 Daily Recap: Saturday Recap
Panelists: Drs. Jack Cush, Michael Putman, Eric Dein, Patricia Harkins and Rachel Tate.
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The Great Debate: To Treat or Not to Treat Pre RA
Dr. Janet Pope and Dr. Jonathan Kay discuss the Great Debate, which Dr. Pope participated in, at ACR22 Convergence in Philadelphia, PA.
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COVID Highlights
Dr. Leonard Calabrese and Dr. Cassandra Calabrese share highlights on COVID data being presented at ACR22 Convergence. Abstract 0793: Autonomic Nervous System Dysfunction Common Among Patients with Long COVID: An Exploratory Evaluation Abstract L08: Breakthrough Acute COVID-19 Infection During the US Omicron Surge Following Administration of Tixagevimab/Cilgavimab in Immunocompromised Patients with Rheumatologic Disorders
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To Switch or Not: Biosimilars in Inflammatory Arthritis
Dr. Jonathan Kay reports on abstract 1112 at ACR22 Convergence.
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Switch vs Cycle in PsA
Dr. Arthur Kavanaugh discusses abstract 1600 at ACR22 Convergence. Abstract 1600: The Impact of Second-Line Therapeutic on Disease Control After Discontinuation of First Line TNF Inhibitor in Patients with PsA: Analysis from the CorEvitas Psoriatic Arthritis/Spondyloarthritis Registry
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New Treatments for SLE?
Dr. Michelle Petri discusses abstract 1117 presented at ACR22 Convergence meeting in Philadelphia, PA. Abstract 1117: Efficacy and Safety of Deucravacitinib, an Oral, Selective, Allosteric TYK2 Inhibitor, in Patients with Active Systemic Lupus Erythematosus: A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study
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Best of PsA on Day 1
Dr. Rachel Tate discusses the best PSA data presented Saturday, November 12, 2002 at ACR22 Convergence. Abstract 0387: Sleep Quality in Patients with Psoriatic Arthritis and Its Relationship with Activity and Comorbidity Abstract 0377: Differences in Early-onset vs. Late-onset Psoriatic Arthritis: Data from the RESPONDIA and REGISPONSER Studies
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Urinary Biomarkers in Lupus
Dr. Jack Cush interviews Dr. Andrea Fava about Abstract 536 at the ACR22 Convergence meeting in Philadelphia, PA. Abstract 0536: Change in Urinary Biomarkers at Three Months Predicts 1-year Treatment Response of Lupus Nephritis Better Than Proteinuria
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A Novel Treatment Response Measurement Tool for Lupus
Dr. Kathryn Dao discusses abstract 2054 with Dr. Eric Morand at the ACR22 Convergence meeting. Abstract 2054: Towards a Novel Clinician-Reported Outcome Measure for SLE – Outcomes of an International Consensus Process.
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David Liew drdavidliew
3 years 10 months ago
Infections in JAKi v TNFi in RA
We've seen ORAL Surveillance data
What about East Asian pts, with enriched zoster risk?
National KOR🇰🇷 insurance data:
Bacterial: equal
Opportunistic: TNFi worse
Zoster: JAKi worse
serious zoster a lot more common here!
ABST0302 #ACR22 @RheumNow https://t.co/lxsbY1Nf9N
TheDaoIndex KDAO2011
3 years 10 months ago
“Conflict, crisis and resolution make a story. A good story has drama where there is desire with danger.” @cuttingforstone author, Dr. Verghese noted the COVID19 #pandemic has all of these elements. It is a good story, but we don’t know the resolution. @Rheumnow #ACR22 https://t.co/Tomev2SYcT
Dr. John Cush RheumNow
3 years 10 months ago
RheumNow’s expanded coverage of the #ACR22 Annual meeting is sponsored in part by Novartis. All content chosen by RheumNow & its Faculty.
A new treatment for AxSpA that has come on the scene are JAK inhibitors. In clinic, considerations for JAKi use are body mass index, smoking status, prior use of biologics and patients with high inflammatory states such as high CRP and inflammatory change on MRI scan of the spine and sacroiliac joints. There are further studies at #ACR22 which help answer these questions.
A Japanese large scale claims data study was able to collect 5-year data to study the treatment patterns in Still’s. In May 2019, intravenous tocilizumab was approved in Japan for Still’s disease. The study was designed to see patterns of steroid exposure before and after the approval of this therapy.
Eric Dein ericdeinmd
3 years 10 months ago
Let’s do this #ACR22
@RheumNow #rheumpix https://t.co/zTx4TynK44
Dr. John Cush RheumNow
3 years 10 months ago
AS, Lupus and Subclinical RA: What I'm looking forward to at #ACR22
There are three areas that always draw my attention each conference and this time is no different...
https://t.co/1h7NRgcqCm https://t.co/9P1UwrmjxW
Type I interferon (IFN) is a powerful immune activator that is present at high levels in the majority of patients with lupus, an autoimmune disease.
Despite a wealth of treatment options, a number of notable unmet needs remain in PsA, most notably the significant diagnostic delay that many patients endure. We are all aware that those with psoriatic skin disease are the most at risk cohort for PsA. Identifying patients with psoriasis who have, or are at increased risk of PsA, appears to be the low hanging fruit that we just can’t fully seem to grasp.
The COVID-19 pandemic has had a significant impact worldwide particularly among those who are immunocompromised. Numerous studies have highlighted the increased risk of acute SARS-CoV-2 infection among patients with rheumatic diseases (RD). Public health measures including masking, social distancing, and vaccination have helped to lower the risk of acute SARS-CoV-2 infection in this population.
Dr. Antoni Chan synovialjoints
3 years 10 months ago
Progression from non-radiographic to radiographic AxSpA is not the norm
● 16% progress over 5 years, 10-25% over 10 years
● Syndesmophytes in 20% over 4 years
● Male, MRI+ at baseline, response to NSAIDs are predictors of progression
Jose U Scher, Review @RheumNow #ACR22 https://t.co/FatodINTfn
Dr. Antoni Chan synovialjoints
3 years 10 months ago
ASAS-EULAR Rec for AxSpA 2022
◦ NSAIDs are first line
◦ b/tsDMARDs when ASDAS >2.1
◦ Uveitis/IBD ➤TNFi
◦ Psoriasis ➤IL-17i
◦ Review Dx if Rx failure
◦ Switch if active disease confirmed
◦ Taper bDMARDs if sustained remission
Jose Scher #ReviewCourse @RheumNow #ACR22 https://t.co/8fGwlZWBDS
Dr. Antoni Chan synovialjoints
3 years 10 months ago
IL-17i Ixekizumab (IXE) continuation superior to withdrawal in preventing relapse in PsA
● Withdrawal resulted in relapse at median 22 wk
● Continuation vs withdrawal 38% vs 85% relapse
● 96% regained control after reinstating IXE
Jose Scher #ReviewCourse @RheumNow #ACR22 https://t.co/TgIRe14Vud
Dr. Antoni Chan synovialjoints
3 years 10 months ago
Think of paraneoplastic presentations for
◦ RS3PE 16-30% malignancy
◦ PPP 12% pancreatic ca
◦ HPOA 1% lung ca
◦ EF 10% haem ca
◦ LCV 4% malignancy
◦ Erythromelalgia 10% haem ca
Screen for malignancies esp if treatment resistant
Capelli L #ReviewCourse @RheumNow #ACR22 https://t.co/tEaf7wCAcj
