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Anti-Rheumatic Rx

      #Positive #RCT of #Nipocalimab a FcRn receptor inhibitor in #Sjogrens #Disease

      👏Phase 2 +RCT

      ESSSDAI and ESPRI both

      Janet Pope Janetbirdope

      9 months 2 weeks ago
      #Positive #RCT of #Nipocalimab a FcRn receptor inhibitor in #Sjogrens #Disease 👏Phase 2 +RCT ESSSDAI and ESPRI both improved 🤷‍♀️what it means to lower #antibodoes #Ro #La Excited for Phase 3 results #ACRBest #ACR24 @RheumNow @ACRheum abst#2527 https://t.co/NeeYT7VR16
      @drceowen @TheLancetRheum @RheumNow Efficacy in newly diagnosed & established PMR is not necessarily interchangeable

      David Liew drdavidliew

      9 months 2 weeks ago
      @drceowen @TheLancetRheum @RheumNow Efficacy in newly diagnosed & established PMR is not necessarily interchangeable different treatment paradigm ?different immunologically Many other diseases have different Rx for induction vs maintenance, early dx vs established. Having said that: doesn't look great for MTX. https://t.co/89lByaYdYq
      Lot said about #ACR24 ABST1697:
      MTX in newly diagnosed PMR, neg RCT
      Many have said no hope for MTX in PMR now

      Agree doe

      David Liew drdavidliew

      9 months 2 weeks ago
      Lot said about #ACR24 ABST1697: MTX in newly diagnosed PMR, neg RCT Many have said no hope for MTX in PMR now Agree doesn't bode well However, MTX may still have role in established PMR @drceowen & I have made that call a priori @TheLancetRheum https://t.co/ywCJc0zHzC @RheumNow https://t.co/JUXk2tDNyR
      It is NO LONGER a ACCEPTABLE
      To NOT consider
      #MMF or #Cyclo + another proven #Rx
      Added to
      #HCQ and #tapering /limiti

      Janet Pope Janetbirdope

      9 months 2 weeks ago
      It is NO LONGER a ACCEPTABLE To NOT consider #MMF or #Cyclo + another proven #Rx Added to #HCQ and #tapering /limiting #glucocorticoids RCTs in #lupus #nephritis support this ? Is which to add #belimumab #CNI #volclosporin #obinutuzimab #ACR #ACRbest @RheumNow @ACRheum https://t.co/a7WMFfCyXl
      JAK-pot! How fast do DMARDs work?

      Dr. Mike Putman interviews Dr. Kim Lauper about abstract 0501, How Fast Do JAK-inhibi

      Dr. John Cush RheumNow

      9 months 2 weeks ago
      JAK-pot! How fast do DMARDs work? Dr. Mike Putman interviews Dr. Kim Lauper about abstract 0501, How Fast Do JAK-inhibitors, TNF-inhibitors, Abatacept and IL-6 Inhibitors Act in Rheumatoid Arthritis? An International Collaboration of Registers of Rheumatoid Arthritis Patients… https://t.co/GO9EwyrVpV https://t.co/lELE5SJW5i
      Highlights from Day 3 at ACR24 included the plenary session presentation on Nipocalimab (previously reviewed), but the big highlight was the Lupus Nephritis guideline recommendations.
      This has been an interesting ACR meeting in terms of PMR updates. I would argue that we are still far too wedded to glucocorticoids only in the management of PMR. Yes, some patients will do fine with just glucocorticoids but we persist far too long with a glucocorticoid only strategy in others who clearly need an alternative as glucocorticoid adverse events multiply.
      Continuing or Stopping Low Dose Glucocorticoids in GPA

      Dr. Mike Putman reports about plenary session abstract 0774 (the

      Dr. John Cush RheumNow

      9 months 2 weeks ago
      Continuing or Stopping Low Dose Glucocorticoids in GPA Dr. Mike Putman reports about plenary session abstract 0774 (the TAPIR study) about how and when patients can stop steroids in GPA. #ACR24 https://t.co/OWqN0jmkc1 https://t.co/foOaVRtGiV
      I've shared some thoughts on @RheumNow on methotrexate, tocilizumab, and baricitinib in PMR based on #ACR24 https://t.co

      Richard Conway RichardPAConway

      9 months 2 weeks ago
      I've shared some thoughts on @RheumNow on methotrexate, tocilizumab, and baricitinib in PMR based on #ACR24 https://t.co/WXiW1nLN4k
      Potential Impact of Weight Loss Drugs in Rheumatic Diseases

      Dr. Arthur Kavanaugh highlights a session regarding weight

      Dr. John Cush RheumNow

      9 months 2 weeks ago
      Potential Impact of Weight Loss Drugs in Rheumatic Diseases Dr. Arthur Kavanaugh highlights a session regarding weight loss and improvement in disease outcomes, specific weight loss drugs (SGL-2 and GLP-1), along with downsides when patients stop these medications. Reporting… https://t.co/Ilu2FXK2xi https://t.co/7CKSnfuey4
      A#2652
      NEWTON study 🇫🇷 Retrosp cohort

      51% relapse. Median @8.7 mos, dose 9mg pred
      Rf: limb art involv- HR 1.9
      Pre

      Eric Dein ericdeinmd

      9 months 2 weeks ago
      A#2652 NEWTON study 🇫🇷 Retrosp cohort 51% relapse. Median @8.7 mos, dose 9mg pred Rf: limb art involv- HR 1.9 Pred taper speed not risk for relapse Most relapse -> incr GCs Toci 1/3 at dx, 50% stopped -61% d/c due to remission, 39% SEs -1/3 relapse after d/c @RheumNow #ACR24 https://t.co/NP0wieDmvo
      Peyrac et al. 211 GCA. Relapse in 52% at median 261 days (so 1st year). 83% on GCs at relapse, median dose 6.5mg pred. 3

      Richard Conway RichardPAConway

      9 months 2 weeks ago
      Peyrac et al. 211 GCA. Relapse in 52% at median 261 days (so 1st year). 83% on GCs at relapse, median dose 6.5mg pred. 36% relapse post-toc discontinuation, at median 133 days. 64% no relapse when toc stopped, at median 511 days @RheumNow #ACR24 Abstr#2652 https://t.co/NqtdDNGGoc https://t.co/mXD8x7O6Ww
      Study by Maria Dall'Era et al. compared voclosporin-based triple immunosuppressive therapy with high-dose GC in active l

      Antoni Chan MD (Prof) synovialjoints

      9 months 2 weeks ago
      Study by Maria Dall'Era et al. compared voclosporin-based triple immunosuppressive therapy with high-dose GC in active lupus nephritis. - Fewer adverse events in the voclosporin group, despite a higher incidence of specific issues like decreased GFR and hypertension. - 25%… https://t.co/ToRu2rdErC https://t.co/uUXzNNuLDb
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