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      The rising placebo response rates in PsA trials are linked to global recruiting patterns, with more studies in less affl

      Antoni Chan MD (Prof) synovialjoints

      9 months 4 weeks ago
      The rising placebo response rates in PsA trials are linked to global recruiting patterns, with more studies in less affluent countries. Limited access to healthcare may drive this trend, highlighting the need for awareness among stakeholders. Plenary Abstr#0722… https://t.co/FplpSlIamR https://t.co/NIp76IS6TZ
      More evidence: persistence of imaging abnormalities is probably NOT an adequate metric of LVV tx failure

      Boiardi et al

      Brian Jaros, MD Dr_Brian_MD

      9 months 4 weeks ago
      More evidence: persistence of imaging abnormalities is probably NOT an adequate metric of LVV tx failure Boiardi et al - 87% TAK/LV-GCA pt w persistent dz on imaging despite clinical remission, TAK>GCA PET avidity more persistent in GCA @RheumNow #ACR24 Abstract 1617
      Which immunomodulators dampen recombinant zoster vaccine immunogenicity?

      In this 🇧🇷 study in autoimmune dx patien

      David Liew drdavidliew

      9 months 4 weeks ago
      Which immunomodulators dampen recombinant zoster vaccine immunogenicity? In this 🇧🇷 study in autoimmune dx patients, overrepresented in non-responders are: - rituximab pts - 'combined therapy' strategies needed for them but reassuring for the others! #ACR24 ABST0248 @RheumNow https://t.co/he1ICa9WZg
      Kerschbaumer et al. Rising placebo rates in PsA RCTs appear linked to changes in global recruitment patterns. Dramatic r

      Richard Conway RichardPAConway

      9 months 4 weeks ago
      Kerschbaumer et al. Rising placebo rates in PsA RCTs appear linked to changes in global recruitment patterns. Dramatic relationship between GNI and placebo response rate. Crucial information for properly planning future trials @RheumNow #ACR24 Abstr#0772 https://t.co/PtHs2RXe0f https://t.co/OKG6czQrYD
      #Frailty leads to poor outcomes and occurs earlier in RA patients. Different tools measure frailty as a phenotype vs. de

      Jiha Lee JihaRheum

      9 months 4 weeks ago
      #Frailty leads to poor outcomes and occurs earlier in RA patients. Different tools measure frailty as a phenotype vs. deficit accumulation. Discover the role of frailty in ED from #LancetRheum Ageing Series by Drs. Sarah Lieber and @KWyshamMD ! #ACR24 @RheumNow ABST#1334 https://t.co/25XQBDQMCo
      Location of research matters Ab#0772
      Global recruiting patterns impact PBO in PsA
      PBO results improve w time - 0.9%/year

      Eric Dein ericdeinmd

      9 months 4 weeks ago
      Location of research matters Ab#0772 Global recruiting patterns impact PBO in PsA PBO results improve w time - 0.9%/year More globalization of trials w time Gross nation index (GNI) neg ass w ACR20 - inclusion of less affluent controls affects higher PBO response @RheumNow #ACR24
      Poster#0035
      🚨Postpartum RA Risk & Mucosal Immunity

      👩‍🍼Elevated anti-CCP-IgG in cervicovaginal fluid of p

      Caoilfhionn Connolly CaoilfhionnMD

      9 months 4 weeks ago
      Poster#0035 🚨Postpartum RA Risk & Mucosal Immunity 👩‍🍼Elevated anti-CCP-IgG in cervicovaginal fluid of postpartum women (n=25) vs. controls. 🧪Local anti-CCP production despite negative serum ❓Childbirth-associated mucosal inflammation may drive RA onset. #ACR24 @RheumNow https://t.co/plvtyJDSY1
      To GLP or not to GLP—is it still even a question in obesity management given pluripotent benefits 👇🏻

      Dr. Louis

      Caoilfhionn Connolly CaoilfhionnMD

      9 months 4 weeks ago
      To GLP or not to GLP—is it still even a question in obesity management given pluripotent benefits 👇🏻 Dr. Louis Aronne recommends ➡️ Start low and titrate slow 💊 ➡️ Provide pt education on GI side effects, ondansetron effective for nausea #ACR24 @RheumNow https://t.co/SzVg2dopCo
      SELECT-GCA Trial results show UPA 15 mg + 26-week GC taper leads to 46% sustained remission vs. 29% with placebo + 52-we

      Antoni Chan MD (Prof) synovialjoints

      9 months 4 weeks ago
      SELECT-GCA Trial results show UPA 15 mg + 26-week GC taper leads to 46% sustained remission vs. 29% with placebo + 52-week taper (P=.0019). UPA15 reduced GC use (median 1615mg vs. 2882mg, P<.0001) and improved fatigue scores. Key finding: UPA15 combined with a 26-week GC… https://t.co/rdHU3GuOwc https://t.co/oMS7x46sIB
      Mycophenolate isn't great for vaccine immunogenicity, but withholding MMF for one week after both doses of recombinant z

      David Liew drdavidliew

      9 months 4 weeks ago
      Mycophenolate isn't great for vaccine immunogenicity, but withholding MMF for one week after both doses of recombinant zoster vaccine boosts Ab titres ++ in this Brazilian RCT. A week off post-vaccine: definitely worth considering in stable disease #ACR24 ABST0247 @RheumNow https://t.co/lajS5DzRbD
      CKD keeps a persistent low grade inflammatory state! Implications: CKD ⬆️risk for CV dz through different mech @Rheu

      TheDaoIndex KDAO2011

      9 months 4 weeks ago
      CKD keeps a persistent low grade inflammatory state! Implications: CKD ⬆️risk for CV dz through different mech @RheumNow #ACR24 https://t.co/KcCvyTVaav
      Safety data reassuring with UPA 15 mg vs PBO
      No UPA MACE events, low VTE
      Ab#0770
      @RheumNow #ACR24 https://t.co/lMf2dCz2R

      Eric Dein ericdeinmd

      9 months 4 weeks ago
      Safety data reassuring with UPA 15 mg vs PBO No UPA MACE events, low VTE Ab#0770 @RheumNow #ACR24 https://t.co/lMf2dCz2RX https://t.co/3DnPIoVOt8
      Planned to post so much more from #ACR24; my favorite slides from today will have to suffice.

      From the #BCRC Dr Monic

      Kristen Young kristenyoung

      9 months 4 weeks ago
      Planned to post so much more from #ACR24; my favorite slides from today will have to suffice. From the #BCRC Dr Monica Guma’s - diet and microbiome. Dr @NamrataRheum -a reminder that we are all aging. Dr Connie Weyand’s -metabolic checkpoints in RA T cells and macrophage. https://t.co/MtsheVsUEQ
      Hypophosphatasia:
      🦴Inherited disorder of metabolism with low tissue nonspecific alkaline phosphatase (TNSALP)
      🦴Imp

      Mrinalini Dey DrMiniDey

      9 months 4 weeks ago
      Hypophosphatasia: 🦴Inherited disorder of metabolism with low tissue nonspecific alkaline phosphatase (TNSALP) 🦴Impaired bone mineralisation 🦴Accumulation of pyrophosphate 🦴1/100,000-300,000 🦴6 main forms @RheumNow #ACR24
      Différent patterns of organ involvement in sarcoidosis @RheumNow #ACR24 #Sarcoidosis https://t.co/xigkS3vpUh

      Antoni Chan MD (Prof) synovialjoints

      9 months 4 weeks ago
      Différent patterns of organ involvement in sarcoidosis @RheumNow #ACR24 #Sarcoidosis https://t.co/xigkS3vpUh
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