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One of the hot topics during the meeting was gender differences in SpA. Three abstracts presented addressed issues related to these differences particularly in the aspects of treatment response and disease activity.
Janet Pope Janetbirdope
1 month ago
Sustained Complete Renal Remission
➡️v strict endpoint in #lupus #nephritis trial from 1 yr to 3yr f/u
▶️all added to #LN SoC
#Voclosporin 20.1% vs #placebo 11.8%
Better if 1 visit only didn’t meet endpoint
➡️ then 10% more per group
ACRBest ACR24 @ACRheum @RheumNow abst1545
Richard Conway RichardPAConway
1 month ago
Conaghan et al. LEVI-04, neurotrophin-3 inhibitor in knee OA. 518 patients. Significant improvements in WOMAC pain and function, and PGA. So sign of any increase in rapidly progressive OA (as with NGF inhibitors) @RheumNow #ACR24 Abstr#L15 https://t.co/qud4wTAikY https://t.co/0wjjG4U4bf
Antoni Chan MD (Prof) synovialjoints
1 month ago
Late breaking abstract L16
Dapirolizumab Pegol showed significant improvement in SLE disease activity in our Phase 3 trial.
Key findings:
- 49.5% of patients achieved BICLA response at Week 48 vs 34.6% on placebo (p=0.0110).
- 60.1% achieved SRI-4 response vs 41.1% on placebo… https://t.co/ZawdsLOxmK https://t.co/gpV3KayIW1
Mike Putman EBRheum
1 month ago
PHOENYCS GO, RCT of dapirplizumab, novel CD40Li in SLE
Met primary endpoint (NNT~6 for BICLA) & numerical improvements in many other endpts
1 MI & 1 death from infection over 213 pts
Encouraging for sure! Second phase 3 being launched
#ACR24 @RheumNow Abstr#L16 #ACRbest https://t.co/QwDMKjhFvb
Dr. John Cush RheumNow
1 month ago
RheumNow’s expanded coverage of the #ACR24 Annual meeting is sponsored in part by Novartis. All content is chosen by RheumNow & its faculty
Janet Pope Janetbirdope
1 month ago
In order to have a
#DMOAD in knee #osteoarthritis
➡️ early detection may be v important
Study of early pt Symptoms was done
2/3 had pain
1/2 #joint Swelling
Need biomarkers & sensitive imaging in early #OA as symptoms are
NOT uniform
#ACR24 @RheumNow @ACRheum abst2111 https://t.co/K94m9rOjtP
Janet Pope Janetbirdope
1 month ago
Pts w #osteoarthritis and T2 DM
👇
Who Have
⬆️pain
Have
worse control of #diabetes
Even after adjusting for #BMI
Chicken or egg - which comes 1st
🤷♀️
#ACR24 @RheumNow @ACRheum
Abst#2110 https://t.co/eN2xAw0EMG
Janet Pope Janetbirdope
1 month ago
Does #hand #osteoarthritis
Benefit from
#traction #splinting?
Nope 👎
Small 2 site #RCT - not helpful
I may Recommend #splinting - sometimes pts get
Pain relief - in my opinion
but this one didn’t help
#ACR24 @RheumNow @ACRheum
Abst#2108 https://t.co/K0Ud7uCb1P
Janet Pope Janetbirdope
1 month ago
How long is a long acting #intra-articular #steroid #injection in #knee #osteoarthritis?
#IA steroids can be q3monthly
#RCT of IA #fluticasone #propionate
Was superior to #placebo
Seemed to last approx 24 weeks
➡️ sub analysis in moderate pain, BMI<30
#ACR24 @RheumNow #2106 https://t.co/QBFCqXd1Q8
Janet Pope Janetbirdope
1 month ago
#Scleroderma #molecular #signatures in #skin predict long term outcomes
👇worst with inflammatory signature
This may have clinical and trial applicability
Nice work!
Abst0711 #ACR24 @RheumNow @ACRheum https://t.co/3CFxu6bACu
Janet Pope Janetbirdope
1 month ago
#PAH in #SSc still has a poor #prognosis
👎
Esp #ILD with PAH - a double whammy
But also
group 1 PAH
And
Some are unclassifiable ▶️also bad px
Need
Earlier detection
More interventions
?prevention
Abst#0678 #ACR24 @RheumNow @ACRheum @sclerodermaUM https://t.co/AEQsTC1pzQ
Janet Pope Janetbirdope
1 month ago
#Positive #RCT of #Nipocalimab a FcRn receptor inhibitor in #Sjogrens #Disease
👏Phase 2 +RCT
ESSSDAI and ESPRI both improved
🤷♀️what it means to lower #antibodoes #Ro #La
Excited for Phase 3 results
#ACRBest #ACR24 @RheumNow @ACRheum abst#2527 https://t.co/NeeYT7VR16
