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      ANCA status does not inform IL-5 agent response in EGPA patients

      Terrier et al. analyzed the OLE of MANDARA and compare

      Brian Jaros, MD Dr_Brian_MD

      1 week 4 days ago
      ANCA status does not inform IL-5 agent response in EGPA patients Terrier et al. analyzed the OLE of MANDARA and compared ANCA+ and ANCA- subgroups: - similar rates of remission - similar rates of GC withdrawal - comparable relapse rates @RheumNow #ACR25 Abst 1594
      Abstract 1657: Can LLMs track medication history?GPT-4 outperformed most LLMs in identifying TNFi start/stop events and

      Akhil Sood MD, MS AkhilSoodMD

      1 week 4 days ago

      Abstract 1657: Can LLMs track medication history? GPT-4 outperformed most LLMs in identifying TNFi start/stop events and reasons for switch. 💊 Common reasons for TNFi switching: lack of effectiveness, adverse events, and insurance/cost barriers. @RheumNow #ACR25 https://t.co/5FUR9tBoyu

      When MAS is suspected. Soluble IL2 receptor alpha and CXCL9 may be useful (however t cell lymphomas and viral infections

      Bella Mehta bella_mehta

      1 week 4 days ago
      When MAS is suspected. Soluble IL2 receptor alpha and CXCL9 may be useful (however t cell lymphomas and viral infections like hepatitis may also have them) #ACR25 @RheumNow Key takeaways below https://t.co/wJv1dvwU88
      Functional MRI studies have been out there for a while, but mechanisms and significance underlying fMRI findings are unc

      Aurelie Najm AurelieRheumo

      1 week 4 days ago
      Functional MRI studies have been out there for a while, but mechanisms and significance underlying fMRI findings are unclear fMRI study in 38 active PsA pts w/ significant fatigue Altered functional connectivity between posterior insula to cerebellum & superior frontal gyrus https://t.co/3s9CJUg2uN
      Soluble IL2 receptors help assess macrophages behavior. Ferritin also asses the same in Macrophage activation syndrome.

      Bella Mehta bella_mehta

      1 week 4 days ago
      Soluble IL2 receptors help assess macrophages behavior. Ferritin also asses the same in Macrophage activation syndrome. ADA2 is the newer biomarker for hemophagocytic syndromes. #ACR25 @RheumNow Interferon gamma also a newer important target in MAS https://t.co/7sWwninBTM
      Simultaneous measurements if S100, Ferritin and IL-18 increase diagnostic utility of these biomarkers in Stills disease.

      Bella Mehta bella_mehta

      1 week 4 days ago
      Simultaneous measurements if S100, Ferritin and IL-18 increase diagnostic utility of these biomarkers in Stills disease. @RheumNow #Acr25 https://t.co/3wmijNcpVY
      Low percentage of glycosylated Ferritin was more specific for Stills disease but not used frequently in clinical practic

      Bella Mehta bella_mehta

      1 week 4 days ago
      Low percentage of glycosylated Ferritin was more specific for Stills disease but not used frequently in clinical practice. @RheumNow #ACR25 https://t.co/wTK1eIcSKX
      #ACR25 Abstr#1532 “The more the merrier” or “Too many cooks..” Preliminary data of CTA313, dual CD19-BCMA CAR-T

      Md Yuzaiful Md Yusof Yuz6Yusof

      1 week 4 days ago

      #ACR25 Abstr#1532 “The more the merrier” or “Too many cooks..” Preliminary data of CTA313, dual CD19-BCMA CAR-T in 15 #SLE pts showed deep depletion & good response. Global study is planned. Will have to keep on eye on safety (G3 herpes zoster, pneumonia & neutropenia) @RheumNow https://t.co/0KQa9K6bYB

      Biomarkers in Stills disease and MAS. #ACR25 @RheumNow
      IL 6 may not be helpful compared to CRP, and IL 1 beta is diffic

      Bella Mehta bella_mehta

      1 week 4 days ago
      Biomarkers in Stills disease and MAS. #ACR25 @RheumNow IL 6 may not be helpful compared to CRP, and IL 1 beta is difficult to measure IL-18 seems to be the best one. https://t.co/u3oBTd4eaP
      #ACR25 Abstr#1608 10! 10! Across the board. 2-yr data from RCT + Open Label showed frequency of both airway and non-airw

      Md Yuzaiful Md Yusof Yuz6Yusof

      1 week 4 days ago
      #ACR25 Abstr#1608 10! 10! Across the board. 2-yr data from RCT + Open Label showed frequency of both airway and non-airway features of #EGPA improved with Benralizumab/Mepolizumab. Provides assurance to use more in real-world @RheumNow https://t.co/i78xXojGja
      IL- 18 go together sometimes with glycolytic enzymes such as aldolase
      Also MAS may not be a switch on and off mechanism

      Bella Mehta bella_mehta

      1 week 4 days ago
      IL- 18 go together sometimes with glycolytic enzymes such as aldolase Also MAS may not be a switch on and off mechanism. Lastly MAS with Stills may have increased IL18 levels but not in other disease like SLE #ACR25 @RheumNow https://t.co/BW1fD7usBT
      What do we know about IL-18
      Normal levels less than 500
      Non specific 500 to 15000
      Stills (quiet) 2000 to 10000
      Mas/glar

      Bella Mehta bella_mehta

      1 week 4 days ago
      What do we know about IL-18 Normal levels less than 500 Non specific 500 to 15000 Stills (quiet) 2000 to 10000 Mas/glares 20000 and more @RheumNow #ACR25 https://t.co/ZAltAD5Q8V
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