Wasn’t following the SLE stuff #EULAR2023 but heard a lot of talk about both telitacicept & CAR-T, including meeting highlights by Christian Dejaco. Both look pretty exciting - the longer the sustained remission with CAR-T, the more it looks like maybe the real deal @RheumNow https://t.co/oKzb8ojTcz

#EULAR2023 #POS1156 Previous case series reported ~9% de novo nephritis in #SLE pts treated with belimumab for non-renal lupus. Post-hoc analysis of 5 BEL Non-LN RCTs showed 8% had de novo LN. Risk increased in Asians but lowered with low dose BEL or s/c form @RheumNow https://t.co/GqAr3tppWh

New 2023 @eular_org SLE recommendations Key changes, in response to evidence: - more caution re: steroids - biologics earlier - combo therapy (BEL or CNI/VCS) considered for lupus nephritis #EULAR2023 @RheumNow https://t.co/J3Lp8owRyT

Key points from #EULAR2023 on how to manage SLE @RheumNow https://t.co/vJy7Cg7w8N

#ClinicalPearl This is cool - think of SGLT2 for #lupus #nephritis? presented at #SLE recommendations ⁦@RheumNow⁩ #EULAR2023 ⁦@eular_org⁩ https://t.co/8mbNt2n64v

#SLE #EULAR recommendations What is new - use LESS #glucocorticoids, aim for none or 5 mg/d or less, use #biologics early if needed to prevent damage, #lupus #nephritis consider less pulse dose if using, voclosporin vs Belimumab ? it depends @RheumNow #EULAR2023 https://t.co/Ylnnl3pHOK

Diagnostic delay in #lupus is really prevalent! #EULAR2023 @RheumNow 20% with new lupus diagnosis are hospitalized! 20% diagnosis is delayed for more than 3 months! https://t.co/1vCcezBrQS

Meds in #lupus at #EULAR2023 recs - HCQ first line therapy. Target dose remains the same. Some discussion on monitoring levels if possible - MAIN CHANGE - Glucocorticoids to be minimized (only use for bridging). Nephrologists more so in favor of steroid free remission @RheumNow https://t.co/d8WnUOgrwq

CAR-T cells in refarctory SLE- long term data presented #EULAR2023 Pts did well except some mild cytopenias. Pts remained in remission. Maybe a good option in the near future for refractory pts! @RheumNow https://t.co/NWoFBipOiQ

With the single cell RNA sequencing analysis being my more affordable (relatively) and widely used! Science is moving forward. Highlights in basic science and translational data #EULAR2023 @RheumNow https://t.co/sS7xLeNyLW