Substudy of SELECT-COMPARE trial Week 60 immunogenicity RZV RA treated UPA 15 mg + MTX ✔️ HUmorale response 71% ✔️ Cellular response 65% ✔️ No serious AEs ✔️ One event of HZ occurred during follow up Abstr#OP0020 #EULAR2024 @RheumNow https://t.co/8OMwGuIZFx

• https://twitter.com/AurelieRheumo/status/1800934293604098449/photo/1

Novel B cell depleters! Bispecific T cell engagers (BiTEs) being studied for #SLE & #RA as a way to get CAR-T cell like responses but more accessible w/less risk for CK release syndrome. #EULAR24 T cell-engaging therapies — BiTEs and beyond | Nature Reviews Clinical Oncology

Nordic country analysis of mortality in RA (n 1145), RA-ILD (239), population ILD (378) & nl controls (1890) shows most mortality in pop ILD (HR 8.3), but less in RA-ILD (HR 3.6). Why is death less in latter; could it be RA therapies? Abstr #POS0022 # EULAR2025 https://t.co/wFZq49rIiW

More data from Jak-pot, the real-world multinational RA study, this time looking at infection in 14 national registries JAKi (vs TNFi) had no signal for general/serious infection (excluding HZ) Somewhat reassuring post-ORAL Surveillance infection data #EULAR2024 OP0092 @RheumNow https://t.co/ocAbc4NiV2

• https://twitter.com/drdavidliew/status/1800922236372791605/photo/1

Nice idea from Erlangen: B cell then T cell suppression for ACPA+ RA. A tolergenic reset of sorts. Sounds interesting… small study, but sadly no difference over ritux only. Does seem broadly safe though - maybe will be a strategy for another disease! #EULAR2024 OP0069 @RheumNow https://t.co/mXUS4kpRCK

• https://twitter.com/drdavidliew/status/1800913243084628403/photo/1
• https://twitter.com/drdavidliew/status/1800913243084628403/photo/1

OP0053 #EULAR2024 @RheumNow #EULARBest Effect of #RTX in preclinical #RheumatoidArthritis RA-risk pts given 1 dose PBO or 1000mg RTX RTX in RA-risk pts delayed onset of RA by 1yr; no benefit on QoL Pts developing RA: RTX didn't alter PROs or disease severity when developing RA

Shingrix in upadacitinib + MTX RA, in SELECT-COMPARE RCT: data now out to 60w good humoral and cellular response in most, even without MTX withheld (& good safety too) Important for our JAKi-treated patients to get the protection they need #EULAR2024 OP0020 @RheumNow https://t.co/FqVCCwUJOg

• https://twitter.com/drdavidliew/status/1800906791502647424/photo/1
• https://twitter.com/drdavidliew/status/1800906791502647424/photo/1

AMPLIFIED study: abatacept vs adalimumab in RF+ACPA+ early RA Not a single blink of difference. Maybe for high CCP titre but the inverse for low CCP. Sadly, theoretical mechanistic benefit doesn’t always wash out. We’ll keep on looking for predictors #EULAR2024 OP0007 @RheumNow https://t.co/IswCub9lLn

• https://twitter.com/drdavidliew/status/1800903614220894485/photo/1

@Janetbirdope @RheumNow #EULAR2024 JAK-i Debate @drdavidliew (NOT in support of regulation) - is the signal real? Query about replicability & data came from N. America. Not reflected on real-world data of enriched cohorts - is the warning justified? - are there unintended consequences? @RheumNow https://t.co/TXUf90fqwN

• https://twitter.com/Yuz6Yusof/status/1800875811693867070/photo/1
• https://twitter.com/Yuz6Yusof/status/1800875811693867070/photo/1

Asking the quintessential Australian question at #EULAR24 by @drdavidliew - does the ORAL surveillance study for JAKi *truly* pass the pub test? @eular_org @Janetbirdope @RheumNow What does #MedTwitter think? https://t.co/bqwPU8XX5S

• https://twitter.com/benjaminsutu/status/1800875690486792649/photo/1
• https://twitter.com/benjaminsutu/status/1800875690486792649/photo/1
• https://twitter.com/benjaminsutu/status/1800875690486792649/photo/1

#EULAR2024 JAK-i Debate. @Janetbirdope [Pro Regulatory Safety Measures] - to do no harm esp since there are other alternatives - supported by RCT - although JAK-i have different structures, data from individual RCT + LTE showed similar rates of malignancy & MACE @RheumNow https://t.co/jQKQmHE9Fg

• https://twitter.com/Yuz6Yusof/status/1800871776114860105/photo/1
• https://twitter.com/Yuz6Yusof/status/1800871776114860105/photo/1

CATCH cohort study of 547 Early RA pts shows higher Tender > Swollen joint differences is assoc. w/ worse n patient-reported outcomes (PROs) in all domains (phys function, social , pain, sleep problems, fatigue, anxiety, depression) -- Isnt this FM ? https://t.co/4Bk8VGQNB6 https://t.co/K7kO5q990v

• Having More Tender Than Swollen Joints Is Associated With... : JCR: Journal of …

Medicare & Optum claims data study of 2851 #RA pts w/ breast cancer (BC). In 3 mos before BC 27028% received bDMARDs. W/in 1st 3 yrs post-BC Dx 24-26% were receiving bDMARDs. 70% of RA pts on steroids without change w/ time https://t.co/51NcXv0xyc https://t.co/461NZiFvDO

• Utilization of Biologic Disease‐Modifying Antirheumatic Therapy in Patients Wit…

Molecular Profile for Cardiovascular Risk in Rheumatoid Arthritis A new study led has managed to establish, for the first time, the molecular profile of those patients with rheumatoid arthritis who have a higher risk of suffering cardiovascular events. https://t.co/VVKR2G91VQ https://t.co/ZZNLJpoyNA

• Molecular Profile for Cardiovascular Risk in Rheumatoid Arthritis | RheumNow