Vasculitis
6 months ago
LBA0001 UPA in GCA- Phase 2 RCT
15mg UPA with 26w steroid taper showed
⬆️ efficacy
⬇️ steroid use
vs placebo with 52w steroid taper
Potential new target on the horizon for #GCA??
@RheumNow #EULAR2024
6 months ago
Enjoyed the #PolymyalgiaRheumatica session at #EULAR2024? Make sure to download our first atlas imaging article, where @drceowen, @drdavidliew et al. characterise PMR using whole-body PET/CT 👀
➡️ https://t.co/tbu0DgAFIS https://t.co/W06YbYyjRx
6 months ago
Maintenance of remission in GPA/MPA.
RTX for 48 months sounds good to me.
#EULAR2024 https://t.co/5YGwOHhCuX
6 months ago
#wasup in #GCA?
#upadacitinib +RCT in #temporal #arteritis LBA0001
Residual #inflammation in 1/3 of pts at 6 mo #Rx w #TCZ on repeat TA Bx
OP0621
#PMR cases
#Leflunomide beats #MTX for
#pred sparing
⬇️relapses
But MTX dose was low
POS0280
#EULAR2024 @RheumNow @eular_org
6 months ago
#EULAR2024 POS1420 A cohort study with 1/3 each with GCA, PMR and GCA+PMR found that at 6mth, 16% of patients had new diabetes/diabetes worsened. Worse in GCA+PMR group with the greatest GC accumulation. Call for better GC-sparing strategy @RheumNow https://t.co/ex7u83bVfj
6 months ago
#EULAR2024 POS0742 A single cohort study showed for non-criteria #APS, cardiac manifestation (valvular dysfunction & regurgitation) was more common in Triple Ab+ vs Non-Triple Ab. We should monitor and consider an echocardiogram for this group of patient @RheumNow https://t.co/VxFUSpjaG1
6 months 1 week ago
If your GCA flares, do you get the same features as you did at diagnosis?
20% of the time it can be new, so keep on doing the checklist!
(also, visual flares uncommon - the power of pred)
#EULAR2024 POS0110 @MayoClinic @MdWarrington @RheumNow https://t.co/hkF8vJT6HI
6 months 1 week ago
Just a reminder - large vessel involvement is very common in GCA, and lines up with aortic dilatation. And if you don’t look, you won’t find…
#EULAR2024 POS0932 @RheumNow https://t.co/2uZTu0B18Z
6 months 1 week ago
Prof Hellmich takes us through “What is new?” In ANCA #vasculitis
A tour de force in management strategies and, continuing a theme of #EULAR2024, ends with a study suggesting the potential of #CAR-T!
@RheumNow https://t.co/K3dDqZhUvD
6 months 1 week ago
Predicting who will develop
▶️#GCA
In #Swedish study with
#PMR
⬆️ in HIGH ESR/CRP
⬆️female
⬇️ if hip pain/stiffness
Not all sig 1 mo after #prednisone started
Only 9% with #polymyalgia #rheumatica developed #GCA
? ⬇️GCA % in PMR over time
#POS0411 @eular_org @RheumNow https://t.co/UMhxlYd0Pv