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Psoriatic arthritis

      Difficult-to-treat & early PsA at #EULAR2025

      GRAPPA definitions: D2T-PsA (≥3 therapies incl ≥2 b/tsDMARDs with

      Antoni Chan MD (Prof) synovialjoints

      4 months 2 weeks ago
      Difficult-to-treat & early PsA at #EULAR2025 GRAPPA definitions: D2T-PsA (≥3 therapies incl ≥2 b/tsDMARDs with persistent inflammation); C2M-PsA (broader: comorbidities, pain, intolerance). 95% GRAPPA consensus. Abstact OP0175 @RheumNow #EULAR2025 https://t.co/eqKmMPh80x
      Data from Dutch registry SpA-Net explored prevalence using new definitions for D2M axSpA.
      -Smoking and psoriasis were ch

      Adela Castro AdelaCastro222

      4 months 2 weeks ago
      Data from Dutch registry SpA-Net explored prevalence using new definitions for D2M axSpA. -Smoking and psoriasis were characteristics associated with D2M disease. -In the three variations explored, the lowest prevalence was observed in the variation based purely on objective https://t.co/h3f4ORQl0F
      Sex differences in biologic response in PsA.
      DISCOVER-2 post hoc analysis showed:
      •Radiographic progression at Week
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      Antoni Chan MD (Prof) synovialjoints

      4 months 2 weeks ago
      Sex differences in biologic response in PsA. DISCOVER-2 post hoc analysis showed: •Radiographic progression at Week ♂️: 2.22 units ♀️: 1.10 units •Early ACR-like response (cDAPSA LDA at 8wks) linked to less damage in men (0.39 vs 2.24) Women less likely to progress https://t.co/NhBkXbuLjO
      Exciting results from ARGO trial:
      -Phase 2 of Sonelokimab (dual IL-17A-IL17F) nanobody in PsA.
      -Met primary endpoint of

      Adela Castro AdelaCastro222

      4 months 2 weeks ago
      Exciting results from ARGO trial: -Phase 2 of Sonelokimab (dual IL-17A-IL17F) nanobody in PsA. -Met primary endpoint of ACR50 at week 12 vs PBO. -62% achieved MDA -48% achieved composite of ACR 70+PASI 100 Looking forward to phase 3 results!!! Abstract #OP0096 #EULAR2025 https://t.co/1D52eG8ReS
      Biomarker data suggest TNFi non-responders in PsA exhibit upregulation of IL-17F gene signatures after treatment failure

      Antoni Chan MD (Prof) synovialjoints

      4 months 2 weeks ago
      Biomarker data suggest TNFi non-responders in PsA exhibit upregulation of IL-17F gene signatures after treatment failure. Supports IL-17A/F blockade rationale with bimekizumab in TNFi-experienced patients Abstract#OP0091 @RheumNow . #EULAR2025 https://t.co/CWR6ArDRRW
      Real-world study on dual bDMARD plus JAKi or TYK2i combinations in refractory PsA. 22 PsA patients on dual bDMARD + JAK

      Antoni Chan MD (Prof) synovialjoints

      4 months 2 weeks ago
      Real-world study on dual bDMARD plus JAKi or TYK2i combinations in refractory PsA. 22 PsA patients on dual bDMARD + JAKi/TYK2i: •Most common: IL-17i + TYK2i •Total exposure: 8.5–10.5 pt-years •Only mild URIs/stomatitis •Clinical improvements seen in joint/skin domains https://t.co/waDReDqSDE
      SPEED RCT: In early PsA with poor prognostic factors, PASDAS at 24wks:
      •Early TNFi: 3.7
      •Combo csDMARDs: 4.1
      •Step

      Antoni Chan MD (Prof) synovialjoints

      4 months 2 weeks ago
      SPEED RCT: In early PsA with poor prognostic factors, PASDAS at 24wks: •Early TNFi: 3.7 •Combo csDMARDs: 4.1 •Step-up csDMARDs: 4.7 Early TNFi beat step-up by -1.09 (p<0.001); combo csDMARDs also superior (-0.69, p=0.02). Early TNFi benefit sustained at 48wks. Abstract#OP0089 https://t.co/MpazF8BIr2
      Hepcidin detected in synovial membrane and fluid in RA, PsA, and OA. Monocytes were the main source. IL-6, IL-10, IL-17,

      Antoni Chan MD (Prof) synovialjoints

      4 months 2 weeks ago
      Hepcidin detected in synovial membrane and fluid in RA, PsA, and OA. Monocytes were the main source. IL-6, IL-10, IL-17, M-CSF induced hepcidin via JAK-STAT pathway. Hepcidin reduced osteoclastogenesis but correlated with synovial neutrophils and CXCL1 induction. Functional dual https://t.co/ZjUtTYPre8
      Cool technology reduces dose interval of #IL17AFi
      To…every 6 to 12 months!

      #Antibody ORKA-002 has end of arms w YTE

      Janet Pope Janetbirdope

      4 months 2 weeks ago
      Cool technology reduces dose interval of #IL17AFi To…every 6 to 12 months! #Antibody ORKA-002 has end of arms w YTE substitution prolonging circulation of drug Lasts longer than #bimekizumab Easier for adherence! #EULAR2025 @RheumNow @eular_org #abstPOS0016 https://t.co/KcKaIe0WMs
      Phase 3 of POETYK-PsA-2:
      -Deucravacitinib (oral TyK2i) met the primary endpoint of ACR20 at week 16 and was superior to

      Adela Castro AdelaCastro222

      4 months 2 weeks ago
      Phase 3 of POETYK-PsA-2: -Deucravacitinib (oral TyK2i) met the primary endpoint of ACR20 at week 16 and was superior to placebo in multiple PsA domains. -Clinical efficacy maintained until week 52. -No major safety signals reported. -Notably high placebo response rates. Abstract
      Despite the advances in the treatment of PsA with biologic (bDMARD) and targeted synthetic (tsDMARD), less than half of patients with this condition achieved remission or low disease activity. Combination DMARD treatment is often used in order to achieve remission or minimal disease activity. The standard practice is to use a conventional synthetic (csDMARD) with a bDMARD. The use of the combination of bDMARD with a tsDMARD such as a JAKi or
      Data from a German cohort evaluated the frequency of D2M-axSpA using the new D2M definition and showed:
      > Female pts

      Adela Castro AdelaCastro222

      4 months 2 weeks ago
      Data from a German cohort evaluated the frequency of D2M-axSpA using the new D2M definition and showed: > Female pts > Peripheral SpA symptoms < HLAB27 positive < Education level < Objective signs: MRI-inflammation in the spine or elevated CRP levels. also PROs were worse in
      ❓️How effective and safe is it to combine bDMARDs and tsDMARDS (i.e. TNFi/ IL17i + JAKi/TYKi) in #psoriatic_arthrit

      Nelly ZIADE 🍀 Nellziade

      4 months 2 weeks ago
      ❓️How effective and safe is it to combine bDMARDs and tsDMARDS (i.e. TNFi/ IL17i + JAKi/TYKi) in #psoriatic_arthritis? 🅰️ Reassuring data from a case-series study presented by Andre Lucas Ribeiro #EULAR2025 OP0090 @RheumNow #Strategy https://t.co/W8fuzSgxbJ
      Ph 2 RCT Sonelokimab (IL-17A- & IL-17F-inhibiting Nanobody) 24wks
      207 pts SON 120 MDA 51% vs. 45% ADA
      Subgroups: fem

      Aurelie Najm AurelieRheumo

      4 months 2 weeks ago
      Ph 2 RCT Sonelokimab (IL-17A- & IL-17F-inhibiting Nanobody) 24wks 207 pts SON 120 MDA 51% vs. 45% ADA Subgroups: female 52%, weight ≥100kg 53%, ≥3% BSA 55% Composite ACR70/PASI100 SON 120 48% vs. 19% ADA No new safety signal Ph 3 on the way 2 doses SON 60 &120 #OP0096 https://t.co/w5QtpKbi1W
      Efficacy and safety of deucravacitinib up to week 52 in the POETYK PsA-2 study
      •ACR20 at W16: 54.2% (deucravacitinib)

      Antoni Chan MD (Prof) synovialjoints

      4 months 2 weeks ago
      Efficacy and safety of deucravacitinib up to week 52 in the POETYK PsA-2 study •ACR20 at W16: 54.2% (deucravacitinib) vs 39.4% (placebo), p=0.0002 •PASI75: 40.9% vs 15.4%, p<0.0001 •MDA: 25.6% vs 14.7%, p=0.0007 •FACIT-F: +2.5 vs +1.8 •SAE: 1.9% (low) TYK2 inhibition shows https://t.co/JXTZRk2itA
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