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Mrinalini Dey DrMiniDey
3 months ago
💉Early results from a dose-escalation trial of novel CD19xCD3xCD28 trispecific antibody (CC312) in refractory #SLE show no ICANS or ≥G2 CRS, rapid B cell depletion & 100% SRI-4 response (n=5).
@RheumNow #EULAR2025 #LB0007 #CART
Md Yuzaiful Md Yusof Yuz6Yusof
3 months ago
#EULAR2025 Abstr#LB0005 Phase IIb RCT in moderate #Sjogren reported significant reduction in ESSDAI at WK24 from BL in HCQ-Leflunomide vs PBO. CRESS & STAR improved. No significant difference in UWS, Schirmer, & ESSPRI. Future work: cohort of high symptom burden @RheumNow
Aurelie Najm AurelieRheumo
3 months ago
The relation between RA, comorbidities and presenteism
NRAS survey 891 RA pts
75% had at least one comorbidity
Absenteeism more likely if
One OR = 1.68 or Two OR = 2.26 comorbid conditions
In particular
Anxiety OR = 2.39
Depression OR = 1.75
Osteoarthritis OR = 1.85
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Nelly ZIADE 🍀 Nellziade
3 months ago
The transformative potential of integrating ePROMs into AI care pathways
🔺️Study by Dr Antoni Chan et al. achieved a new-to-followup ratio of 1:2.5 outperforming the national average of 1:4.2
🔺️Without losing contact with pts
@synovialjoints
POS1271
#EULAR2025
@RheumNow https://t.co/z3jO3ADHR1
Mrinalini Dey DrMiniDey
3 months ago
🦵🏻SAP-001, a novel uricosuric targeting a non-URAT1 renal transporter, lowered sUA <6 mg/dL in up to 79% of patients with refractory #gout on b/g xanthine oxidase inhibitor. >50% on 60 mg/day reached sUA <3 mg/dL.
💊Potential new oral ULT option.
@RheumNow #EULAR2025 #LB0008 https://t.co/dfY1V5sHSh
Aurelie Najm AurelieRheumo
3 months ago
Why do Rheumatologists shift to private practice? Are there gender based differences?
A survey of 100+ European rheumatologists
Female 🚺 rheumatologists:
Leave hospital earlier
At a lower hierarchical level
Reasons for leaving:
nightshifts
unfair promotion decisions
Nelly ZIADE 🍀 Nellziade
3 months ago
EULAR PtC for definition of #TR Trt Refractory) #Psoriatic_Arthritis
#D2M
1️⃣ Failure >= 2 b/tsDMARDs
2️⃣ Problematic
3️⃣ Evidence of persistent dis
+
4️⃣ Exclude drivers like comorbidities & psychosocial factors
🔺️Exclude failure due to Side Effets/CI
#EULAR2025
@RheumNow https://t.co/ULD2Xe6p6A
Bella Mehta bella_mehta
3 months ago
Will climate change impact rheumatological care?
#EULAR2025 @rheumnow
Especially larger cities are are affected more.
Need to worry about comorbidities https://t.co/KhTyAssGeI
Nelly ZIADE 🍀 Nellziade
3 months ago
Imagine #Barcelona with an additional 8 degrees in summer 🔥 🔥🔥
Session: Disaster Medicine - Impact of climate change, heat, and global insecurity
#EULAR2025
@RheumNow https://t.co/1TqlBJtoZD
Bella Mehta bella_mehta
3 months ago
RA is worst with temperature rising/ climate change.
However SpA has the opposite effect!
Climate change session at #EULAR2025 @RheumNow https://t.co/eKVXnfdEzD
Adela Castro AdelaCastro222
3 months ago
Tips for Dx RP:
1. Suspect the dx and recognize chondritis.
2. Rule out mimickers
3.Tracheal involvement shows swelling>stenosis (helps ≠from GCA)
4. CV, heme, derm manifestations 🧐VEXAS.
5. biopsy not useful unless ≠ from GCA.
Fantastic session by @Lupusreference https://t.co/W4DgfeRULF
Md Yuzaiful Md Yusof Yuz6Yusof
3 months ago
#EULAR2025 Abstr#POS1155 Fatigue remains a management challenge in #SLE. Consistent with other endpoints achieved, Dapirolizumab+SOC improved fatigue (FACIT-Fatigue & FATIGUE-PRO) over PBO+SOC in a Phase 3 RCT @RheumNow https://t.co/rYujy2YjBl
Aurelie Najm AurelieRheumo
3 months ago
What do we do when we see Rx signed of CPPD in RA pts? Do these pts have different trajectory?
Rx Retro study 388 patients RA
18% at least one sign CPPD
ns diff between seeonegative and seropositive pts
RA+CPPD group was
-older
-higher comorbidity score
-more likely to be https://t.co/DaW5DZoDzF
Bella Mehta bella_mehta
3 months ago
Vector borne diseases that result in arthritis will rise with climate change/ flooding risk
- Chikungunya
- Dengue
- Zika
- West-Nile Virus
@RheumNow #EULAR2025 https://t.co/HtHyADsOSX
Nelly ZIADE 🍀 Nellziade
3 months ago
Climate Change Impacts #Rheumatology Care Taking
HEAT 🥵 causes:
🔺️⬆️ Hospitalisations
🔺️Renal failure ⚠️ NSAIDs
🔺️Flooding: no access to healthcare
🔺️New Infectious diseases mimics RMDs: Zika...
🔺️Insecurities for drug storage and transportation
#EULAR2025
@RheumNow https://t.co/V9RyxYX6Me
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