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      #OP091 at #EULAR2026: RA was associated with a 44% higher risk of ischaemic stroke versus the general population, with h

      Mrinalini Dey DrMiniDey

      1 week 2 days ago
      #OP091 at #EULAR2026: RA was associated with a 44% higher risk of ischaemic stroke versus the general population, with higher stroke-related mortality and disability. Encouragingly, excess stroke risk was no longer significant in more recent RA cohorts. @RheumNow
      Izokibep IL-17A Affibody PsA

      343 pts RCT PBO crossover wk16
      52 wks data
      ACR50 50–57% ACR70 36–42% PASI100 64% MDA

      Aurelie Najm AurelieRheumo

      1 week 2 days ago
      Izokibep IL-17A Affibody PsA 343 pts RCT PBO crossover wk16 52 wks data ACR50 50–57% ACR70 36–42% PASI100 64% MDA 47–52% No diff between QW vs Q2W AE Injection-site reactions, URTIs most common No new safety signals Looks like any other IL17Ai to me #EULAR2026 #OP073 https://t.co/WiHT8Plitn
      Can we intercept PsA?

      Retro study 394 PSO pts 17 yrs follow-up 86 PsA

      TNFi linked to higher PsA incidence vs IL- MoA
      T

      Aurelie Najm AurelieRheumo

      1 week 2 days ago
      Can we intercept PsA? Retro study 394 PSO pts 17 yrs follow-up 86 PsA TNFi linked to higher PsA incidence vs IL- MoA TNFi 45% vs IL-17i 14% vs IL-23i 10% vs IL-12/23i 11% After adjustment IL-17i HR 0.35 IL-23i HR 0.17 Needs prospective confirmation! #OP072 #EULAR2026 https://t.co/88RaukjLjY
      #OP090 at #EULAR2026: In this nationwide Danish study, RA patients with lung cancer had similar survival outcomes to pat

      Mrinalini Dey DrMiniDey

      1 week 2 days ago
      #OP090 at #EULAR2026: In this nationwide Danish study, RA patients with lung cancer had similar survival outcomes to patients without RA. Importantly, immune checkpoint inhibitor treatment did not appear to worsen outcomes in patients with pre-existing RA. @RheumNow
      At Week 52 with izokibep in #PsA PASI90: 63–69%; PASI100: 55–64%; MDA: 47–52%. The small-molecule format may enabl

      Antoni Chan MD (Prof) synovialjoints

      1 week 2 days ago
      At Week 52 with izokibep in #PsA PASI90: 63–69%; PASI100: 55–64%; MDA: 47–52%. The small-molecule format may enable deeper tissue penetration. Novel anti-IL-17 approach. Abstr#073 @RheumNow #EULAR2026 #Biologics https://t.co/IaJ1gyECZu
      Izokibep (novel small IL-17A inhibitor, 18.6 kDa) maintained efficacy to Week 52 in active #PsA with ~50% of patients ac

      Antoni Chan MD (Prof) synovialjoints

      1 week 2 days ago
      Izokibep (novel small IL-17A inhibitor, 18.6 kDa) maintained efficacy to Week 52 in active #PsA with ~50% of patients achieving ACR50 and nearly half reaching MDA. Sustained durable response with no new safety signals Abstr#OP073 @RheumNow #EULAR2026 https://t.co/Y6fTirE886
      #OP089 at #EULAR2026 provides real-world data on biologic use after new cancer diagnoses in RA. Continuing biologics in

      Mrinalini Dey DrMiniDey

      1 week 2 days ago
      #OP089 at #EULAR2026 provides real-world data on biologic use after new cancer diagnoses in RA. Continuing biologics in early-stage cancer, & restarting them in many stage 2-3 cancers, was not associated with worse 5-year survival in this Japanese registry study. @RheumNow https://t.co/OdCPiCxFEq
      22% of psoriasis patients developed #PsAover 17 years of follow-up. PsA occurred in 44% of TNFi-treated vs only 9–14%

      Antoni Chan MD (Prof) synovialjoints

      1 week 2 days ago
      22% of psoriasis patients developed #PsAover 17 years of follow-up. PsA occurred in 44% of TNFi-treated vs only 9–14% of those on IL-23i or IL-12/23i. Time to discuss "preventive biologics" in PsO? Prospective controlled trials are needed Abstr#072 @RheumNow #EULAR2026
      #EULAR2025 OP0127 Still trying to get my head around the flat line PBO response. In Sjogren pts with ESSDAI=>5, a Pha

      Md Yuzaiful Md Yusof Yuz6Yusof

      1 week 2 days ago
      #EULAR2025 OP0127 Still trying to get my head around the flat line PBO response. In Sjogren pts with ESSDAI=>5, a Phase 3 RCT of Telitacicept (BAFF/APRIL-i) in China met all endpoints. ESSPRI improved too! Could be because strict concom DMARD inc. GC protocol @RheumNow https://t.co/FEhXfNPvfG
      In a 17-year real-world psoriasis cohort, patients on IL-17i had 75% lower odds and IL-23i patients had 84% lower odds o

      Antoni Chan MD (Prof) synovialjoints

      1 week 2 days ago
      In a 17-year real-world psoriasis cohort, patients on IL-17i had 75% lower odds and IL-23i patients had 84% lower odds of developing #PsA vs TNF inhibitors. Is biologic class selection a PsA interception strategy? Prospective controlled trials are needed Abstr#072 @RheumNow https://t.co/jpdZjGK7VV
      #OP088 at #EULAR2026 found that rare deleterious variants in telomere-related genes were associated with increased RA-IL

      Mrinalini Dey DrMiniDey

      1 week 2 days ago
      #OP088 at #EULAR2026 found that rare deleterious variants in telomere-related genes were associated with increased RA-ILD risk, independent of MUC5B status. The effect size was similar to that seen in idiopathic pulmonary fibrosis. @RheumNow
      #Autoimmune #progressive #pulmonary #fibrosis

      Large Spanish registry

      ❎more mortality if not on #DMARDs
      ?underRx of p

      Janet Pope Janetbirdope

      1 week 2 days ago
      #Autoimmune #progressive #pulmonary #fibrosis Large Spanish registry ❎more mortality if not on #DMARDs ?underRx of proven #Rx with #antifibrotics Median survival post #dx #PPF 7.8 yrs Can we do better? #ABST POS0430 @RheumNow #EULAR2026 https://t.co/gP7apxfEPS
      Multiparametric renal MRI in LN:
      Structural MRI can differentiate bet. active and stable dse
      Exudative = active inflamm

      sheila RHEUMarampa

      1 week 2 days ago
      Multiparametric renal MRI in LN: Structural MRI can differentiate bet. active and stable dse Exudative = active inflamm In quanti analysis, low ADC values may reflect fibrosis. A potential non-invasive biomarker? OP092 @rheumNow #EULAR2026 https://t.co/IarTGOen7v
      DIPSA RCT: diet in PsA

      92 pts 3 arms Mediterranean vs DASH low-calorie vs standard advice

      Primary takeaway: amount of

      Aurelie Najm AurelieRheumo

      1 week 2 days ago
      DIPSA RCT: diet in PsA 92 pts 3 arms Mediterranean vs DASH low-calorie vs standard advice Primary takeaway: amount of weight loss matters more than diet! -All groups lost modest weight 1–2.5 kg -All improved similarly in DAPSA -4 to -6 wk 24 -No differences for disease https://t.co/U0cxtdl2Yb
      #OP0112 at #EULAR2026: Real world RISE registry data shows incr use of semaglutide and tirzepatide across RMDs, particul

      Mrinalini Dey DrMiniDey

      1 week 2 days ago
      #OP0112 at #EULAR2026: Real world RISE registry data shows incr use of semaglutide and tirzepatide across RMDs, particularly RA and PsA. Tirzepatide achieved greater weight loss than semaglutide, with ongoing analyses assessing effects on disease activity and function. @RheumNow
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