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Anti-Rheumatic Rx

      A study exploring the benefits of treating RA patients to remission after achieving low disease activity (LDA).
      Key find

      Antoni Chan MD (Prof) synovialjoints

      9 months 2 weeks ago
      A study exploring the benefits of treating RA patients to remission after achieving low disease activity (LDA). Key findings: - Among patients initially at LDA, achieving remission (CDAI ≤2.8) led to significantly better functional outcomes and reduced durable medical equipment… https://t.co/SNPKlRieur https://t.co/YIQNMf3Oap
      Abst#1493 complete renal response (< 0.5 g/g w/< 10 mg/day pred); renal remission (UPCR < 0.3 g/g w/< 5 mg/d

      TheDaoIndex KDAO2011

      9 months 2 weeks ago

      Abst#1493 complete renal response (< 0.5 g/g w/< 10 mg/day pred); renal remission (UPCR < 0.3 g/g w/< 5 mg/day pred). 60 LN pts followed 3 yrs: 40% CRR & 19% RR. Pts not in CRR/RR had⬇️eGFR w/more decline in eGFR over time. No difference b/t CRR/ RR @rheumnow #ACRbest #ACR24

      Steroids in checkpoint inhibitor rheumatic irAEs need to be approached with caution.
      Persistent higher doses earlier on

      David Liew drdavidliew

      9 months 2 weeks ago
      Steroids in checkpoint inhibitor rheumatic irAEs need to be approached with caution. Persistent higher doses earlier on might dampen ICI response. @HSpecialSurgery ICI-IA (inflamm arthritis) cohort big diff in survival based on early steroid exposure #ACR24 ABST1989 @RheumNow https://t.co/3WAZ3ZLbFw
      Rheumatic irAEs can get on the CAR-T bandwagon, too!

      CAR-T can invoke new rheumatological issues (not just cytokine rel

      David Liew drdavidliew

      9 months 2 weeks ago
      Rheumatic irAEs can get on the CAR-T bandwagon, too! CAR-T can invoke new rheumatological issues (not just cytokine release) - see @DrGomezPuerta's experience. Infrequent, but if CAR-T in general becomes common, yet another job for us to attend to... #ACR24 ABST2004 @RheumNow https://t.co/xBSlhUdkNr
      Now that nipocalimab is approved for Sjogren's Disease, what about vaccination response whilst on this FcRn inhibitor (i

      David Liew drdavidliew

      9 months 2 weeks ago
      Now that nipocalimab is approved for Sjogren's Disease, what about vaccination response whilst on this FcRn inhibitor (inherently lowers IgG)? Actually, not bad: takes a little longer to get there, but reassuring! (always fun to get to know a new med) #ACR24 ABST1988 @RheumNow https://t.co/IYqIGo5xVP
      Here’s a collection of some of the best abstracts presented on day 2 of ACR 2024 as selected by the RheumNow faculty. 
      Post hoc analysis of SPIRIT H2H evaluated nail involvement as a measure of ttnt response in PsA.
      -Pts with nail involvem

      Adela Castro AdelaCastro222

      9 months 2 weeks ago
      Post hoc analysis of SPIRIT H2H evaluated nail involvement as a measure of ttnt response in PsA. -Pts with nail involvement treated with IXE or ADA had higher SJC and TJC improvement vs those without involvement at W12, W24 and W52. -IXE achieved rapid response for DAPSA-LDA as… https://t.co/SR36qCthQo https://t.co/hI3tD5hATJ
      Plenary sessions began the day, followed by thousands on the abstract floor. Here are a few of my favorite presentations from day 2 at ACR 2024.
      With the advent of FDA-approved anti-obesity medications such as semaglutide and tirzepatide, a new avenue for managing this challenging patient population has emerged. But how might these drugs impact the trajectory of RA, and are we on the cusp of a paradigm shift?
      The anti-MCTD group strikes back

      Of cohort of over 1,000 RNP+ pt, only 17 clinically diagnosed with MCTD

      Majority of p

      Brian Jaros, MD Dr_Brian_MD

      9 months 2 weeks ago
      The anti-MCTD group strikes back Of cohort of over 1,000 RNP+ pt, only 17 clinically diagnosed with MCTD Majority of patients, despite potential overlap, treated for other primary rheum dz @RheumNow #ACR24 https://t.co/vkQ6UPs34y
      In this systematic review & metaanalyis by Dr. RFarhat et al, tacrolimus whole blood levels decrease in the 1st &amp

      sheila RHEUMarampa

      9 months 2 weeks ago
      In this systematic review & metaanalyis by Dr. RFarhat et al, tacrolimus whole blood levels decrease in the 1st & 2nd trimesters then increase back to pre-pregnancy levels postpartum. Needs further studies to guide dose adjustment. @RheumNow #ACR24 abs1535 https://t.co/5MovzPJoFc
      Ab1676 discussed an intervention to change patient mindsets about side-effects of #methotrexate. Watch my video for @Rhe

      Mrinalini Dey DrMiniDey

      9 months 2 weeks ago
      Ab1676 discussed an intervention to change patient mindsets about side-effects of #methotrexate. Watch my video for @RheumNow on this abstract here: https://t.co/NxuxQ5wYda #ACR24
      For decades, glucocorticoids (GCs) have formed the backbone of polymyalgia rheumatica (PMR) management. Whilst previously there was a sense that a “low” GC dose with limited duration was used, we now appreciate just how heterogenous the disease course of PMR can be, with many patients experiencing frequent relapses and garnering a subsequent huge GC burden over a number of years.
      How do you manage skin in Sscl?
      -RNA pol III + high risk for skin progression.
      -Limited+ low risk + stable Sscl no need

      Adela Castro AdelaCastro222

      9 months 2 weeks ago
      How do you manage skin in Sscl? -RNA pol III + high risk for skin progression. -Limited+ low risk + stable Sscl no need for immunesuppresors. -Look for EF in pts with generalized morphea. -Ttnt of skin depending on other organ involvements. -If no Raynaud’s/hands spared think of… https://t.co/HBjO5eQfjT https://t.co/oS1ZmkanGA
      Sarilumab is better than #MTX in #PMR

      Reminder #RCT of #MTX in #PMR was a NEGATIVE #trial #1697

      60 % #sarilumab in #RW

      Janet Pope Janetbirdope

      9 months 2 weeks ago
      Sarilumab is better than #MTX in #PMR Reminder #RCT of #MTX in #PMR was a NEGATIVE #trial #1697 60 % #sarilumab in #RWE could d/c #Prednisone after failure of initial #pred #Rx >1yr pred prior vs 40% MTX Comparative effectiveness sari v MTX #1700 #ACR24 @ACRheum @RheumNow https://t.co/4YXIBz0OK7
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