Quaack etlal. PreCARA study (vs PARA, historical control). T2T in RA improves fertility - time to pregnancy 84 days vs 196 days. T2T strategy also led to less NSAIDs and prednisolone. @RheumNow #ACR24 Abstr#1647 #ACRbest https://t.co/vYCCUqpCLo https://t.co/PUHJOxgGbL

• Improved Fertility in Women with Rheumatoid Arthritis and a Wish to Conceive Wh…
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#2282 🔬 Personalised Approach to TNFi in RA 📊 N=50👇; 43 responders 🔑 Findings 💥TNFR2 rs1061622 polymorphism linked to TNFi response 💥 MR/RR alleles ⬆️ 10X odds non-response v. MM allele (OR = 10.1,p=0.04) 🎯Genotyping may guide personalized RA therapy. #ACR24 @RheumNow https://t.co/MQKZUCEPxj

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#1330 🔬F-Calprotectin in Early RA ➡️ New-onset RA pts(n=104) had ⬆️ F-calprotectin vs controls(n=50)(71 v. 17µg/g; p<0.001) 🔑Higher F-calprotectin linked to ⬆️ DAS28 & NSAID use ⬇️levels @ 6 months Rx ❓Role of subclinical gut inflammation in early RA #ACR24 @RheumNow

Plenary II: pregnancy in RA When a treat to target approach is used to achieve remission, pregnancy rates nearly similar to general population! Time to pregnancy less than half that of non-T2T comparators @RheumNow #ACR24 https://t.co/B9F9M8t9Kt

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Infertility in women with RA 2x higher Risk factors - age - disease activity - use of NSAIDs - use of pred >7.5mg/day With T2T aiming for remission, fertility improves and becomes similar to the general population #ACR24 @RheumNow ABST#1647 https://t.co/B2Tx4dju4Z

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#1350 🔬 Microbiome & RA: Impact on Disease Activity & Vascular Function ➡️ Salivary microbiome a/w arterial stiffness (AIx)(p 0.019) ➡️ Stool microbiome a/w DAS28-CRP(p 0.027) 🔴Key taxa👇identified for each; no common taxa for both disease activity & AIx. #ACR24 @RheumNow https://t.co/54Sumzzd27

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17S19 session on steroid free future @LesleyJacksonMD @EBRheum @BritAdlerMD Is a (near) steroid free future for RA, ANCA, Lupus #ACR24 @RheumNow

#1456 💥In a real-world UK PsA cohort, 25% had joint erosion @ diagnosis ➡️Mean disease duration 34mo. @ diagnosis ➡️Mean disability score = mod. to severe 💥Delay in diagnosis=poor outcomes ‼️Are we doing enough to catch PsA early? ? 🔑Earlier detection key #ACR @RheumNow

#1375🏋️‍♀️ Strength Training in RA ➡️ 12-week trial 28 ♀️ High-intensity(HIRT) v. Low-intensity+blood flow restriction(LIT-BFR) 🔴Equivalent gains:Lat-pulldown, biceps curl 🔴Knee extension:HIRT>LIT-BFR (non-significant) ✅ LIT-BFR: Alternative for RA sarcopenia #ACR24 @RheumNow

Is participation in RISE assoc with improved quality of care? ➡️Enrolment assoc w ⬆️performance in several quality measures ➡️Most marked in practices with lower baseline performance ⏩Registry participation has potential to improve quality of rheum care Ab1644 #ACR24 @RheumNow