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      Selective TYK2i zasocitinib, results of Phase 2 DBRCTDose dependent improvements in various PsA outcomes; NNT~5 for DA

      Mike Putman EBRheum

      1 month ago

      Selective TYK2i zasocitinib, results of Phase 2 DBRCT Dose dependent improvements in various PsA outcomes; NNT~5 for DAS28 remission, NNT~20 for PASDAS Hard to compare to current agents, somewhere between JAKs (woot!) & "apremlist zone" 🫣 #ACR24 @RheumNow Abstr#2584 #ACRbest https://t.co/t0y6C618ll

      A#2585
      PsABIOnd observ cohort study of IL23 (GUS) or IL17i
      6 mo interim results of 686 pts
      PROs: PsAID-12
      High Rx persis

      Eric Dein ericdeinmd

      1 month ago
      A#2585 PsABIOnd observ cohort study of IL23 (GUS) or IL17i 6 mo interim results of 686 pts PROs: PsAID-12 High Rx persistence at 6mo -94% on both Rx Comparable improvement in PsAID-12 - best results skin, discomfort 1/2 with clinically meaningful improvement #ACR24 @RheumNow https://t.co/TM1jwTRR7C
      Dr. CStone et al. assessed nailfold dermoscopy in distinguishing DM from SLE
      Almost all DM pts had nailfold changes in a

      sheila RHEUMarampa

      1 month ago
      Dr. CStone et al. assessed nailfold dermoscopy in distinguishing DM from SLE Almost all DM pts had nailfold changes in at least 1 digit vs. SLE & majority of DM pts had nailfold changes in all 10 digits Dermoscopy is a simple alternative to capillaroscopy @rheumNow #ACR24 ab2404 https://t.co/6tEXAlX7lt
      A systematic review & meta-analysis by Dr. JBCorrea et al show that the ff immune-mediated dses are assocd w/⬆️

      sheila RHEUMarampa

      1 month ago
      A systematic review & meta-analysis by Dr. JBCorrea et al show that the ff immune-mediated dses are assocd w/⬆️ ocurrence risk after covid19 infection 👇 Behcets SpA SS SLE PMR Pso RA Sjogrens T1DM Vasculitis IBD Ask prior covid infexn in pts history @RheumNow #ACR24 abs2614 https://t.co/TIEglPrmvL
      Neuropsychiatric manifestations in SLE.
      Susanne Benseler MD @RheumNow #ACR24 https://t.co/subiykC5Q4

      Antoni Chan MD (Prof) synovialjoints

      1 month ago
      Neuropsychiatric manifestations in SLE. Susanne Benseler MD @RheumNow #ACR24 https://t.co/subiykC5Q4
      A#2586
      EBIO study - secukinumab on entheseal bx in PsA. Compare b/l to 3+ mo on SEC

      Biopsy: change of entheseal cell co

      Eric Dein ericdeinmd

      1 month ago
      A#2586 EBIO study - secukinumab on entheseal bx in PsA. Compare b/l to 3+ mo on SEC Biopsy: change of entheseal cell composition on IL-17A Rx - decr Il-17A producing cells in responding pts Spatial transcriptomics - colocalizarjon of ILC2, CD200+ fibroblasts @RheumNow #ACR24 https://t.co/kMiqpBRxuE
      Neuroimaging is done to support the diagnosis of CNS #lupus but only 75% reveal abnormal brain MRI.
      📌 It is more use

      sheila RHEUMarampa

      1 month ago
      Neuroimaging is done to support the diagnosis of CNS #lupus but only 75% reveal abnormal brain MRI. 📌 It is more useful in pts with local deficits than diffuse. 📌 poorly correlated with cognitive dysfunction & psych phenotypes. @Rheumnow #ACR24 @rheumarhyme @theactiverheum https://t.co/HjNbVBaOHv
      The different NPSLE syndromes 👇
      Highlighted in yellow are the most common manifestations. 🧠
      - Cognitive dysfuncti

      sheila RHEUMarampa

      1 month ago
      The different NPSLE syndromes 👇 Highlighted in yellow are the most common manifestations. 🧠 - Cognitive dysfunction - Mood disorder - Anxiety disorder @RheumNow #ACR24 https://t.co/1I7OVPT6DK
      A higher number of axSpA pts enrolled in BE MOBILE 1&2 who were treated with BKZ achieved remission accdg to the OS

      sheila RHEUMarampa

      1 month ago
      A higher number of axSpA pts enrolled in BE MOBILE 1&2 who were treated with BKZ achieved remission accdg to the OSI vs. ASDAS ID (40.5% vs 15.2%) at wk 16 until wk 52. OSI a better measure of remission? @RheumNow #ACR24 abs2362 https://t.co/GCHjXQi9S9
      Diagnostic work up for neuropsychiatric SLE. Zahi Touma MD @RheumNow #ACR24 https://t.co/zLX1QHCaSu

      Antoni Chan MD (Prof) synovialjoints

      1 month ago
      Diagnostic work up for neuropsychiatric SLE. Zahi Touma MD @RheumNow #ACR24 https://t.co/zLX1QHCaSu
      Dr @ZahiTouma discusses the attribution rules for the NPSLE syndromes
      Attribute to #SLE if
      - onset of NP is near the S

      sheila RHEUMarampa

      1 month ago
      Dr @ZahiTouma discusses the attribution rules for the NPSLE syndromes Attribute to #SLE if - onset of NP is near the SLE dx - absence of concurrent nonSLE factors - ⬇️ frequency of NP events in the gen pop'n - diagnostic tools favor NPSLE @RheumNow #ACR24 https://t.co/e1xBK4Xzsw
      Very informative slide describing the 2 NPSLE pathogenetic pathways & their differences in mediators, mechanisms and

      sheila RHEUMarampa

      1 month ago
      Very informative slide describing the 2 NPSLE pathogenetic pathways & their differences in mediators, mechanisms and NP events. @RheumNow #ACR24 @rheumarhyme @theactiverheum https://t.co/D3XFDqxMBq
      Walsh et al. Direct mailing of PEST questionnaire to psoriasis patients. 13% PEST+, 4% seen by rheum (to date). 75% deem

      Richard Conway RichardPAConway

      1 month ago
      Walsh et al. Direct mailing of PEST questionnaire to psoriasis patients. 13% PEST+, 4% seen by rheum (to date). 75% deemed appropriate for rheum to see - breakdown in picture. @RheumNow #ACR24 Abstr#2635 https://t.co/vlGJ977SV7 https://t.co/dbDUpwDZxy
      Sharma @Amansharmapgi et al. DADA2. Clinical manifestations of 101(!) patients. @RheumNow #ACR24 Abstr#2647 https://t.co

      Richard Conway RichardPAConway

      1 month ago
      Sharma @Amansharmapgi et al. DADA2. Clinical manifestations of 101(!) patients. @RheumNow #ACR24 Abstr#2647 https://t.co/Tkk6Rz6rtT https://t.co/frvFPYy4xf
      A#2647
      DADA2 cohort 101 pts in India
      Median delay dx 5 years - 5 pts of >20 yr
      - 39 pts w GI involvement- bad outcome

      Eric Dein ericdeinmd

      1 month ago
      A#2647 DADA2 cohort 101 pts in India Median delay dx 5 years - 5 pts of >20 yr - 39 pts w GI involvement- bad outcomes Skin most common - largely livedo, then ulcers/nodules CNS common w ischemia Many Rx before dx 12 deaths (11.8%) - 8 GI, 3 CVA, 1 suicide #ACR24 @RheumNow https://t.co/Q8kiVbJq8I

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