People with #rheumatoid #arthritis reporting major stressors in life had worse #pain, #disability, #depression, #fatigue and sleep disturbance at diagnosis and a year later - despite control of disease. Andersen et al (2020) https://t.co/zbPbK49mvD #EULAR2020goesvirtual #EULARHPR https://t.co/qiiBa2h5ez

• https://ard.bmj.com/content/79/Suppl_1/165.2

#EULAR2020 Dr. V Ritschl:EULAR Task Force on Patient Adherance: 30-80% of pts do not adhere to Rx. resulting in ⬆️dz severity, pain, fatigue, depression, decreased in function, physical activity. HCPs should discuss adherance reg. & explore factors affecting adherance. @RheumNow

ENbrel works in long term for the few people left on the drug at 10 yrs with SpA. Enormous dropout. If you are still on Rx for a decade you are in the minority. Drop out of TNFi in SpA mirrors RA & PsA @RheumNow @eular_org @CRASCRRheum @earlyarthritis #EULAR2020 https://t.co/dLS2fw5uRP

• https://twitter.com/uptotate/status/1269358046150643713

Your #RA patients in low disease or remission, do you maintain, reduce or stop DMARDs #EULAR2020

#EULAR2020 Updated RA Mgmt Recc Main points: 1. MTX 1st line (if contraind, then SSZ/LEF; NOT HCQ) 2. Add bDMARD/JAKi if 1st csDMARD doesn't work + poor Px 3. Use IL-6i or JAKi for pts who can only take monoRx and failed csDMARD @RheumNow https://t.co/AIXz2dEOrX

• https://ard.bmj.com/content/79/6/685

Study of the French registries for TCZ, RTX, ABA, compared the risk of GI perforations (GIP). GIP risk was higher with TCZ (vs RTX,ABA) but was largely due to TCZ increasing the risk of diverticulitis. #EULAR2020 #OP0022 https://t.co/MGGWiVh5Jv https://t.co/nC2NblYnGO

• https://bit.ly/2XC5gyX

Do not be tempted to stop MTX or other DMARDs perioperatively! They probably help rather than harm #EULAR2020 https://t.co/jb4ZuZlqSu

RA pt not responding to a 1st biologic; what you predict in a Head to Head - Abatacept vs Upadacitinib?

#EULAR2020 #fri0505 Still’s pts who are able to achieve remissions w/longer itnervals btw tocilizumab infusions & lower dose of prednisone more likely to successfully withdraw Toci. Time to symptom recurrence in relapse group 7.8 mo. Older pts more likely to relapse @RheumNow

Main factors influencing #physicalactivity in inflammatory #arthritis patients are psychological ➡️Main factor related to knowledge of benefits of #exercise & symptoms ➡️Modifiable ➡️Health professional support key FRI0642-HPR #EULAR2020 👉🏽https://t.co/Vdc7rjnC6Y by @DavergneT https://t.co/aMUHA5IMrn

• https://ard.bmj.com/content/79/Suppl_1/921.1

Don’t forget significant fibrosis with ILD has +RCT with nintedanib INBUILD study. Lots of buzz of RA ILD where MTX is OK, TNFi may have more ILD than other bDMARDs, biomatkers KL-6 @eular_org OP0038 #EULAR2020 @CRASCRRheum https://t.co/OihF3LmNYQ

Can we predict which RA pts will have secondary failure to TNFi in advance? B-cell activating factor (BAFF) may play a role, and in age >54, pre-TNFi BAFF levels predict anti-drug Ab. A potential step toward better drug survival? La Paz, Madrid THU0170 #EULAR2020 @RheumNow https://t.co/NRQHO2cVuf

Predictors of not achieving remission in early RA, in Canadian CATCH cohort vary by sex: men: seropos, smokers women: obesity, TJC, lower education Different mechanisms of poor outcomes in early RA in men and women? @earlyarthritis SAT0053 #EULAR2020 @RheumNow https://t.co/fRgm6vtlPL

The link between periodontal disease & anti-CCP seroconversion is well known, but does it affect progression from arthralgias to synovitis after that? @LeedsBRC data says yes for localised periodontitis. Got CCP+ arthralgia? Don't forget to floss! SAT0045 #EULAR2020 @RheumNow https://t.co/CpqRyIWVK0

For a drug that everything in RA has been built on, we're not great at predicting who will respond to methotrexate. It's probably because we don't have all the info. Adding pharmacogenomics increased optimal AI prediction from 55% to 76% @MayoClinic FRI0046 #EULAR2020 @RheumNow https://t.co/bwpSYQIBLG