#EULAR2020 #op0015 relationship btw sUA &mortality in the US: increased mortality in M w/ low sUA but not F. could be attributed to uricosuric effect of uncontrolled hyperglycemia ( high incidence of DM)? Lower Alzheimer’s mortality in M&F w/high sUA. @RheumNow https://t.co/E4HVXASKYy

#EULAR2020 #op0079 ASAS-MRI group offers updated definition of the structural lesions in SI joints in AxSpA: -erosion in >=2 consecutive slices or in >=3 SIJ quadrants - fat lesions w/depth >1cm in >=1SIJ quadrant are high priority candidates @RheumNow https://t.co/EU1WWqJ4h3

#eular2020 #op0205 phase 1 trial of novel URAT1 inhibitor D-0120 in healthy adults: safe up to 20 mg/d after 7 days. Significant reduction of sUA peaks at 4-8h & lasts up to 24h @RheumNow

#EULAR2020 #op0106 Cosentyx 150mg demonstrates clinical improvement in NrAxSpA Sx in Ph3 PREVENT 52wk study. Significant improvement in ASAS40, BASDAI50& ASdAS-CRP ID. MRI BME score significantly decreased (-1.68&-1.03 (no LD) vs -0.39 PBO) @RheumNow https://t.co/UX7mkJ8qMJ

#EULAR2020 #op0169 US claims database analysis reveals that gout and DM make for a dangerous combination: significantly higher risk of amputations in pts with gout+DM at 0.77% as oppose to DM w/out gout 0.461% & gout w/out DM 0.162% @RheumNow

#EULAR2020 #op0201 nationwide cohort study: higher incidence of dementia in SLE (3.9/1000pys) vs non-SLE ( 2.73/1000pys). HR 1.43. In SLE risk of Alzheimer’s 1.4x &risk of vascular dementia 1.6x Higher than non-SLE cohort. Further studies to identify mechanism needed @RheumNow

#EULAR2020 #op0192 UK Biobank and IMPALA studies: metabolic body composition of PsA pts w/increased VAT,ectopic liver fat distribution & ⬆️ abdominal fat index associated w/increased risk of CHD&T2DM @RheumNow https://t.co/CwwAB2yUid

How often do you use MRI of peripheral joints for diagnosis or monitoring of PsA?

#EULAR2020 #op0182 delayed gadolinium-enhanced MRI study reveals proteoglycan loss in articulate cartilage in PsA associated w/severity of periarticular inflammation, synovitis &flexor tenosynovits but not bone erosion or prolypheration. @RheumNow https://t.co/ZJBDnZuYbB

#EULAR2020 #op0202-hpr 🇬🇧 study remind that resistant training benefits patients with inflammatory arthritides: improved function, wellbeing, self-efficacy, strength and fatigue.improved balance&endurance helps prevent falls @RheumNow https://t.co/MH7VD6zH9t

#EULAR2020 #op0143 a nationwide study concludes GCA pts at higher risk for sarcoma (HR 2.14), kidney cancer (1.6), hematological malignancies (HL2.42&non-HL1.66). Overall cancer HR 1.29. Time to diagnosis shorter in GCA (~48mo) vs controls (~58mo) @RheumNow https://t.co/obAlZw2gei

#EULAR2020 #op0148 real world European study of Mepolizumab in 142 pts w/EGPA shows significant improvement of general, ENT, pulm&neuro symptoms. Significant reduction in BVAS, 90%decrease of asthma attacks by 12 mo, decreased steroid use. 21.1%non-serious AEs @RheumNow https://t.co/fN4tKPvUaE

#eular2020 #op0227 52 wk SEC vs ADA H2H EXCEED trial: Acr20 67.4%SEC vs 61.5%ADA. Better retention of SEC at 85.7% vs 76.3%ADA. SEC significantly outperforms in PASI90 (65.4 SEC be 43.2 ADA) @RheumNow https://t.co/M8UGydTFDF

#eular2020 #op0314 5 y drug-free remission (5DFR) is rare in early AxSpA: 17%pts from DESIR cohort reach 5DFR. Shorter disease duration (<1.3y), lower BASDAI&ASAS-CRP & less peripheral involv more likely to achieve DFR. Imaging and biological data did not predict DFR @RheumNow

EULAR2020 #op0168 🇰🇷Population-based cohort study identifies both allopurinol& febuxostat associated with MI, cerebral infarction&cerebral hemorrhage. Fluctuation of sUA&potentially even cardiovascular gout attacks (urate crystals in vasculature) as possible causes @RheumNow https://t.co/mcb5NLnMq1