Olga Petryna DrPetryna
4 years 6 months ago
#Eular2020 #op0224 filgotinib successfully reduces levels of circulating biomarkers in PsA suggestive of clinical efficacy: CRP&SAA >50%, IL6, CXCL10&IL23 >25%. Also decreased ICAM1,VCAM1, MMP1&SC1M @RheumNow
David Liew drdavidliew
4 years 6 months ago
Enticing stuff. Avacopan wins on 52w remission, steroid toxicity/use, renal fx, with minimal toxicity.
Looks good to be a steroid replacement in AAV, with real benefit for patients. Exciting but cost will dictate if we get to use it (see: apremilast) OP0011 #EULAR2020 @RheumNow https://t.co/WTFk21D0KY
Dr Philip Robinson philipcrobinson
4 years 6 months ago
Another Italian COVID-19 dermatology report: 1,193 skin psoriasis patients on TNFi, IL17,IL23,IL12/23 & apremilast: 22 patients infected, of those 5 hospitalised, none died https://t.co/HpN908qsHd
k dao KDAO2011
4 years 6 months ago
#EULAR2020 ABST#OP0012 German RABBIT registry show TNFi has less risk for venothrombolic events HR 0.53 (95% CI 0.33-0.86) compared to csDMARD in RA. Age > 65 years, CRP > 5 mg/L increases risk for VTE, no differences with steroids or smoking status.
@RheumNow https://t.co/Hkv6T7pl9f
k dao KDAO2011
4 years 6 months ago
#EULAR2020 ABST#OP0014 Plenary session: Secukinumab and etanercept do NOT work for anterior uveitis in SpA based on Swedish Rheum Quality Registry of > 2600 patients @rheumnow https://t.co/2kJ3b4JObq
k dao KDAO2011
4 years 6 months ago
#EULAR2020 ABST#OP0015Plenary session: very low serum urate < 4 mg/dL in men assc w/increased CV mortality; 40,000 pt study. NOTE: this may be driven by poorly controlled diabetes as hyperglycemia has a uricosuric effect; from NHANES database @MassGeneralNews @RheumNow https://t.co/jnhkS436JZ
k dao KDAO2011
4 years 6 months ago
#EULAR2020 Plenary Abstr#OP0016 Brilliant study showed how gut microbiota dysbiosis may trigger RA in high risk people (+CCP w/o Sx) using fecal transplantation in a mouse model to trigger collagen induced arthritis @rheumnow
Healthy vs. preclin RA vs. RA microbiota specimen: https://t.co/ZITCAcmuXh
k dao KDAO2011
4 years 6 months ago
#EULAR2020 Abstr#LB001 Coming soon...another indication for @Rinvoq? Favorable response in phase III trial of upadacitinib vs. ADA vs. PCB for PsA (SELECT-PsA-1) @abbvie @rheumnow https://t.co/0udmPlR2pQ
k dao KDAO2011
4 years 6 months ago
After seeing the results of the NORD-STAR early RA trial, would you start a newly diagnosed, treatment naive RA patient on: #EULAR2020 @RheumNow
k dao KDAO2011
4 years 6 months ago
Best advice by Dr. R Landewe @EULAR2020 "Do NOT lose contact with your patients during the pandemic!" Many patients are fearful and will not reach out to their physicians; don't let them get lost in the shuffle. @rheumnow https://t.co/FAkEYexsGo
k dao KDAO2011
4 years 6 months ago
#EULAR2020 OP0020: RABBIT 5500 pt study of all DMARDS/biologics, IL-6 inh may be the best to improve fatigue seen in RA patients @rheumnow https://t.co/VJW8MwMamM
Tatiana Prowell, MD tmprowell
4 years 6 months ago
There have been 1,831,821 cases & 106,181 deaths from #COVID19, a 5.8% conf case-fatality rate. To put it another way, 1 out of 17 Americans w/ confirmed #SARSCoV2 has died. It is now the #1 cause of death in the US. The message is getting lost: this #pandemic is very serious.
k dao KDAO2011
4 years 6 months ago
#EULAR2020 Prof. T Domer: baricitinib show promise in phase II trial for SLE: Microarray analysis noted reduction in IFN signature; however, the reduction did not correlate w/SLEDAI-2K or SRI4 clinical response @RheumNow https://t.co/cW4egzSnAs
k dao KDAO2011
4 years 6 months ago
#EULAR2020 Most innovative! Vaccination with IFNa-kinoid to induce anti-IFNa antibodies to treat SLE (results of phase IIb trial). https://t.co/rM0z23ieQW @RheumNow https://t.co/OYMdDZl6sb
k dao KDAO2011
4 years 6 months ago
#EULAR2020 OP0160 Prospective study of Hopkins Lupus Cohort: HCQ blood levels can predict risk for thrombotic events in SLE. Dr. M Petri advocates this is another reason for monitoring HCQ whole blood levels. Goal HCQ whole blood level should be 1000-1500 ng/mL @rheumnow https://t.co/mM6jsJ2Qmf