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Eric Dein ejdein1
3 years 6 months ago
#EULAR2021 #6899 Dr. Hovius: "Erythema migrans is a clinical diagnosis. If you suspect it, you should not order tests, you should prescribe antibiotics to treat the disease." Remember serologies are negative in early disease!
@Rheumnow
Eric Dein ejdein1
3 years 6 months ago
#EULAR2021 POS0105: Predictors of flare in SLE low disease activity state:
⭐️Ongoing glucocorticoid treatment
⭐️Ongoing immunosuppressant treatment
⭐️Anti-RNP antibody
@RheumNow
Eric Dein ejdein1
3 years 6 months ago
PS0103 #EULAR2021. Do you adjust complement levels by time of pregnancy?
⭐️Mean C3 ⬆️28% compared to 1st trimester
⭐️Mean C4 ⬆️ 11% compared to 1st trimester
@RheumNow
Eric Dein ejdein1
3 years 6 months ago
#EULAR2021 POS0227 recs all patients try subQ MTX before bDMARD. Mirza et al: ⬆️ efficacy & ⬇️side effects with subQ.
May not be for all pts, but subQ ⬆️ efficacy than high-dose PO MTX. ⬇️ GI side effects, but ⬆️ ulcers/hair loss (use folate/leucovorin for this)
@RheumNow
Eric Dein ejdein1
3 years 6 months ago
Yesterday at #EULAR2021: Spacing trial: success in taper anti-TNF for stable SpA. POS0229 C-OPTIMSE study: Certolizumab w/d for SpA remission (continue full dose vs. 1/2 dose vs. placebo). Placebo group had ⬆️ activity scores, 77% flared. Ok to taper, but won't stop Rx @Rheumnow
Eric Dein ejdein1
3 years 6 months ago
#EULAR2021 POS0230: TNFi changes intestinal microbiota in IBD-SpA
⬇️ Proteobacteria
⬆️Lachnospiraceae, Coprococcus
Does inflammatory changes by TNFi restore intestinal eubiosis and does this affect SpA outcomes?
@Rheumnow
Eric Dein ejdein1
3 years 6 months ago
#EULAR2021 OP0291 proposes focus score of 4+ as prognostic factor for lymphoma risk in Sjogrens
Focus score 4+:
⬆️lymphoma risk
⬆️salivary gland swelling
⬆️autoantibodies
⬇️thyroiditis
Authors propose 4yr follow-up biopsy in all pts Focus score 4+.
@RheumNow
Eric Dein ejdein1
3 years 6 months ago
#EULAR2021 LB0001. Mavrilimumab (blocks GM-CSF alpha) phase2 trial in non-vented patients w/ #COVID19 :
⭐️⬇️ mortality and ventilation at day 29
⭐️61% reduction in death (HR 0.39)
⭐️No drug related SAEs, no dose-related AEs
@Rheumnow https://t.co/9UOi3xF7Re
Eric Dein ejdein1
3 years 6 months ago
#EULAR2021 LB0002 #COVID vax safety in RMD
⭐️78% received Pfizer, 16% Astra Zeneca
⭐️5% of pts flares, 1.2% severe flares
⭐️31% had vax side effects, 0.1% severe AEs
Side effect profile similar to gen population. Good data for uncertain patients!
@RheumNow @rheum_covid https://t.co/PGZcph9Mu6
Eric Dein ejdein1
3 years 6 months ago
What’s the biggest reason for vaccine hesitancy in your patients? @RheumNow #EULAR2021
Eric Dein ejdein1
3 years 6 months ago
#EULAR LB0003 Pfizer #COVID vax immunogenicity and safety in 686 rheum pts in Israel
⭐️Sero+ for COVID Ab 86% in RMD vs 100% controls
⭐️RTX lowest seropos of 39%, related to time of infusion
⭐️⬇️ with GC, ABA, MMF
⭐️ MTX not seen to significantly ⬇️
@RheumNow @rheum_covid
Eric Dein ejdein1
3 years 6 months ago
What's your main take-away from COVID vax immunogenicity data at #EULAR2021? LB0003: I'm re-assured that early data has not shown MTX has not shown major ⬇️ in immunogenicity, also seen at @HopkinsRheum @CaoilfhionnMD. Not surprised to see GC, RTX, MMF affect vax. @Rheumnow
Eric Dein ejdein1
3 years 6 months ago
#EULAR2021 Present6882 - Dr. Nikiphorou on diet and RMD: "The Western Diet can be called the greatest enemy of chronic inflammatory conditions." @RheumNow. https://t.co/vWeiyJkbgX
Eric Dein ejdein1
3 years 6 months ago
#EULAR2021 pres6882. Uh oh. @RheumNow Drink in moderation and try green tea, it’s anti-inflammatory! https://t.co/ubYYRO3mMy
Caris Life Sciences carisls
3 years 6 months ago
A better way to fight cancer. Your molecular profile may reveal what treatments may be the most effective in your fight. #CarisCares #PrecisionMedicine #CancerCare
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