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      RT @Janetbirdope: Can machine learning show JAKi effects for safety? Off target binding predicted in #tofacitinib 58,

      Janet Pope Janetbirdope

      4 years 5 months ago
      Can machine learning show JAKi effects for safety? Off target binding predicted in #tofacitinib 58, #baricitinib 41 but NO pathway for thrombosis or viral infection. Could have repurposing for + effects on lung vasculature & antifibrotic effects POS0091 #EULAR2021 @RheumNow
      RT @Janetbirdope: MACE events with #JAKi is as clear as mud! You voted >50% NOT Sure 1/3 only some Jakis vs MACE in #

      Janet Pope Janetbirdope

      4 years 5 months ago
      MACE events with #JAKi is as clear as mud! You voted >50% NOT Sure 1/3 only some Jakis vs MACE in #TNFi! Dunno #EULAR2021 @RheumNow @eular_org https://t.co/vWUgKSwAap
      RT @Yuz6Yusof: Does anti-CD20 mAb still have a place in #Sjogren? Dr Pontarini analysed salivary gland biopsy from TRACT

      Md Yuzaiful Md Yusof Yuz6Yusof

      4 years 5 months ago
      Does anti-CD20 mAb still have a place in #Sjogren? Dr Pontarini analysed salivary gland biopsy from TRACTISS and reported beneficial effects of RTX in⬇️regulating genes involved in immune cell recruitment, activation and organisation in ectopic GC #EULAR2021 #OP0136 @RheumNow https://t.co/FRUvo4JxTx
      RT @MeralElRamahiMD: Do you increase spacing of TNF-i administration in your patients with axSpA with sustained low dise

      Meral K. El Ramahi, MD MeralElRamahiMD

      4 years 5 months ago
      Do you increase spacing of TNF-i administration in your patients with axSpA with sustained low disease activity for one year? OP0138 results showed similar relapse rates in those with increased spacing intervals and those on standard dosing regimen. #EULAR2021 @RheumNowNews
      RT @Yuz6Yusof: Does Guselkumab (IL23-i) modulate gene expression in #PsA? Dr Siebert analysed samples from DISCOVER RCTs

      Md Yuzaiful Md Yusof Yuz6Yusof

      4 years 5 months ago
      Does Guselkumab (IL23-i) modulate gene expression in #PsA? Dr Siebert analysed samples from DISCOVER RCTs & reported normalisation of⬆️regulated genes (e.g. Neutrophil,monocyte) and ⬇️regulated (B-,T- and NK cells) signatures by GUS post-therapy #EULAR2021 #POS0195 @RheumNow https://t.co/2qtpxrrwkF
      RT @Janetbirdope: AVN in SLE is ⬇️ing over time! risks are same: younger, male, glucocorticoids & also found hyp

      Janet Pope Janetbirdope

      4 years 5 months ago
      AVN in SLE is ⬇️ing over time! risks are same: younger, male, glucocorticoids & also found hyperlipidemia. ?due to older age of onset & less steroids over time & better immune suppressants POS0730 @RheumNow #EULAR2021 @eular_org https://t.co/IG3NVrZl4D
      RT @Yuz6Yusof: Once approved, what type of patients with #SLE would you treat with #anifrolumab? #EULAR2021 #OP0131 @Rhe

      Md Yuzaiful Md Yusof Yuz6Yusof

      4 years 5 months ago
      Once approved, what type of patients with #SLE would you treat with #anifrolumab? #EULAR2021 #OP0131 @RheumNow
      RT @doctorRBC: Sjogren’s QoL reported dryness correlates with objective salivary flow
      ⭐️lower perceived dryness a

      Robert B Chao, MD doctorRBC

      4 years 5 months ago
      Sjogren’s QoL reported dryness correlates with objective salivary flow ⭐️lower perceived dryness associated with higher immunologic activity Abs#POS0102 #EULAR2021 @RheumNow
      RT @ejdein1: #EULAR2021 OP0138 - Radiographic AxSpA in LDA, SPACING anti-TNF vs continue care. 83% were able to ⬆️ d

      Eric Dein ejdein1

      4 years 5 months ago
      #EULAR2021 OP0138 - Radiographic AxSpA in LDA, SPACING anti-TNF vs continue care. 83% were able to ⬆️ dosing interval at month 12, drug efficacy recovered in pts with relapsed disease. Worth trying in stable patient who wants to wean down meds. @RheumNow
      RT @Nellziade: Do patients with #SpA have a different phenotype if they have "root joint disease"?
      Find out at the #EULA

      Nelly ZIADE 🍀 Nellziade

      4 years 5 months ago
      Do patients with #SpA have a different phenotype if they have "root joint disease"? Find out at the #EULAR2021 Poster Tour #POS0239 or at https://t.co/30JdHxTKus https://t.co/ocEefm8II9
      RT @Janetbirdope: @AurelieRheumo @RheumNow Looks like modern art and not a prediction model. Lots of scatter in data by

      Janet Pope Janetbirdope

      4 years 5 months ago
      @AurelieRheumo @RheumNow Looks like modern art and not a prediction model. Lots of scatter in data by my untrained eyes! @RheumNow #EULAR2021
      RT @Janetbirdope: @MeralElRamahiMD @RheumNow True that axSpA is diff from pts with peripheral SpA predominantly but isnâ

      Janet Pope Janetbirdope

      4 years 5 months ago
      @MeralElRamahiMD @RheumNow True that axSpA is diff from pts with peripheral SpA predominantly but isn’t it circular reasoning to say axial has more HLAB27+ as that is group in whom criteria were developed including HLAB27?
      RT @Janetbirdope: Poorer outcomes with #JAKi in pts who get #SARSCoV2 but ? related to line of therapy - worse off if 2n

      Janet Pope Janetbirdope

      4 years 5 months ago
      Poorer outcomes with #JAKi in pts who get #SARSCoV2 but ? related to line of therapy - worse off if 2nd line advanced Rx in RA vs 1st line? JAKi has short half life so it washes out? And..#baricitinib added to #remdesivir improves outcomes NEJM @RheumNow #EULAR2021 #OP0006 Dunno! https://t.co/583z6Mlw3y
      RT @Yuz6Yusof: Do we need to monitor #ECG in patients on #HCQ and #polypharmacy? Dr Antivalle reported ⬆️QTc interva

      Md Yuzaiful Md Yusof Yuz6Yusof

      4 years 5 months ago
      Do we need to monitor #ECG in patients on #HCQ and #polypharmacy? Dr Antivalle reported ⬆️QTc interval in HCQ vs controls. Only 3/132 was above ULN in HCQ group though. Importantly,⬆️QTc was noted more in HCQ + co-meds (e.g. PPI) #EULAR2021 #POS0090 @RheumNow https://t.co/1Ui4MghqIk
      RT @doctorRBC: Don’t forget to use imaging that you already have!
      CT Abd/Pelvis (ordered for nonMSK) of 301 IBD pts sh

      Robert B Chao, MD doctorRBC

      4 years 5 months ago
      Don’t forget to use imaging that you already have! CT Abd/Pelvis (ordered for nonMSK) of 301 IBD pts shows underlying sacroilitis ⭐️60/301 had sacroilitis on CT ⭐️11/60 had AxSpA ⭐️3/60 previously undiagnosed axSpA Abs#POS0035 #EULAR2021 @RheumNow
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