EULAR 2024 kicked off with a fantastic debate between Janet Pope and David Liew - ‘JAK inhibitor special warnings: Can observational data debunk an RCT?’ A thought-provoking discussion summarising all aspects of the ongoing conversation on JAKi use in high-risk patients! https://t.co/MzW3jSSCfr

• https://twitter.com/IMIDforum/status/1800883585177747651/photo/1
• https://twitter.com/IMIDforum/status/1800883585177747651/photo/1

More data from Jak-pot, the real-world multinational RA study, this time looking at infection in 14 national registries JAKi (vs TNFi) had no signal for general/serious infection (excluding HZ) Somewhat reassuring post-ORAL Surveillance infection data #EULAR2024 OP0092 @RheumNow https://t.co/ocAbc4NiV2

• https://twitter.com/drdavidliew/status/1800922236372791605/photo/1

OP0053 #EULAR2024 @RheumNow #EULARBest Effect of #RTX in preclinical #RheumatoidArthritis RA-risk pts given 1 dose PBO or 1000mg RTX RTX in RA-risk pts delayed onset of RA by 1yr; no benefit on QoL Pts developing RA: RTX didn't alter PROs or disease severity when developing RA

Shingrix in upadacitinib + MTX RA, in SELECT-COMPARE RCT: data now out to 60w good humoral and cellular response in most, even without MTX withheld (& good safety too) Important for our JAKi-treated patients to get the protection they need #EULAR2024 OP0020 @RheumNow https://t.co/FqVCCwUJOg

• https://twitter.com/drdavidliew/status/1800906791502647424/photo/1
• https://twitter.com/drdavidliew/status/1800906791502647424/photo/1

@Janetbirdope @RheumNow #EULAR2024 JAK-i Debate @drdavidliew (NOT in support of regulation) - is the signal real? Query about replicability & data came from N. America. Not reflected on real-world data of enriched cohorts - is the warning justified? - are there unintended consequences? @RheumNow https://t.co/TXUf90fqwN

• https://twitter.com/Yuz6Yusof/status/1800875811693867070/photo/1
• https://twitter.com/Yuz6Yusof/status/1800875811693867070/photo/1

Asking the quintessential Australian question at #EULAR24 by @drdavidliew - does the ORAL surveillance study for JAKi *truly* pass the pub test? @eular_org @Janetbirdope @RheumNow What does #MedTwitter think? https://t.co/bqwPU8XX5S

• https://twitter.com/benjaminsutu/status/1800875690486792649/photo/1
• https://twitter.com/benjaminsutu/status/1800875690486792649/photo/1
• https://twitter.com/benjaminsutu/status/1800875690486792649/photo/1

#EULAR2024 JAK-i Debate. @Janetbirdope [Pro Regulatory Safety Measures] - to do no harm esp since there are other alternatives - supported by RCT - although JAK-i have different structures, data from individual RCT + LTE showed similar rates of malignancy & MACE @RheumNow https://t.co/jQKQmHE9Fg

• https://twitter.com/Yuz6Yusof/status/1800871776114860105/photo/1
• https://twitter.com/Yuz6Yusof/status/1800871776114860105/photo/1