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Drug Safety

      Should we still be worried about lymphoma developing in RA patients?

      Incidence has plummeted with modern therapy, altho

      David Liew drdavidliew

      4 months 2 weeks ago
      Should we still be worried about lymphoma developing in RA patients? Incidence has plummeted with modern therapy, although still a small risk. TNFi and other bDMARDs don’t seem to confer any real risk. So what should our approach be? Karin Hellgren #EULAR2025 @RheumNow https://t.co/9ZodpojSaz
      #EULAR2025 Abstr#POS0991 RCT showed Adjuvanted Herpes Zoster vaccination appeared safe in #SLE upto 1 year. However, hum

      Md Yuzaiful Md Yusof Yuz6Yusof

      4 months 2 weeks ago
      #EULAR2025 Abstr#POS0991 RCT showed Adjuvanted Herpes Zoster vaccination appeared safe in #SLE upto 1 year. However, humoral and cellular responses declined over time. Longer follow up needed to ascertain frequency of vaccine to be repeated @RheumNow https://t.co/FcUi1OfBLu
      What kills in GCA?

      Greek national prospective cohort, small numbers and no doubt some channeling bias, but:

      Steroids (

      David Liew drdavidliew

      4 months 2 weeks ago
      What kills in GCA? Greek national prospective cohort, small numbers and no doubt some channeling bias, but: Steroids (absence of DMARD use) is more of a factor than CV disease in GCA mortality. With new options, all GCA pts should be on something #EULAR2025 POS0960 @RheumNow https://t.co/Wmvf6tEvaF
      #digital #ulcers in #scleroderma🎯

      Retrospective #iloprost vs #selexipag
      👇
      BIG advantage of oral #prostacyclin re

      Janet Pope Janetbirdope

      4 months 2 weeks ago
      #digital #ulcers in #scleroderma🎯 Retrospective #iloprost vs #selexipag 👇 BIG advantage of oral #prostacyclin receptor #agonist vs iloprost healing faster ⬇️ulcers Selexipag used in iloprost failures; ⬇️IV access WOW! RCT needed #OP035 #EULAR2025 @RheumNow @eular_org https://t.co/6y9LwIlQkd
      SLE Preview: advances to achieve deep B-cell depletion

      The race is on for the first chimeric antigen receptor (CAR)-bas

      Dr. John Cush RheumNow

      4 months 2 weeks ago
      SLE Preview: advances to achieve deep B-cell depletion The race is on for the first chimeric antigen receptor (CAR)-based therapy to be approved for the treatment of systemic lupus erythematosus (SLE). Its main principle is to induce deep B-cell depletion, with the hope to reset https://t.co/OzQ05YFZfb
      New work presented at the 2025 annual EULAR congress in Barcelona focuses on the recombinant zoster vaccine (RZV), which contains recombinant glycoprotein E – the major target of CD4+T-cells. The abstract describes the tolerability and safety of RZV in patients with inflammatory rheumatic and musculoskeletal diseases (iRMD), showcasing interim data from an ongoing study.
      🎯 Early MTX hits the mark — but only in ACPA-negative.
      In TREAT EARLIER, 1 year of MTX led to lasting benefits at 5

      Jiha Lee JihaRheum

      4 months 2 weeks ago
      🎯 Early MTX hits the mark — but only in ACPA-negative. In TREAT EARLIER, 1 year of MTX led to lasting benefits at 5 years: ➖ Less RA ➖ Better function ❌ No benefit in ACPA+ Abstract#OP0324 @RheumNow #EULAR2025
      #ANCA #vasculitis is not created equally

      REVEAL cohort 588 ANCA

      Initial & 12 months #BVAS (activity index)
      mean ?

      Janet Pope Janetbirdope

      4 months 2 weeks ago
      #ANCA #vasculitis is not created equally REVEAL cohort 588 ANCA Initial & 12 months #BVAS (activity index) mean ⬇️BVAS over 1 yr in all groups #GPA #MPA #eGPA 5yr survival not = over time ⬆️survival in eGPA & GPA vs MPA #POS0329 #EULAR2025 @RheumNow @eular_org https://t.co/cUKytqNZnS
      Is there a higher risk of cancer that comes with the disease? Or with the treatments? So many confounding parameters, such as disease duration, disease state, and disease activity come into play. A promising session explored comorbidities in Rheumatoid Arthritis, in particular cancer and cardiovascular events. Here are my takeaways.
      Day 2 was a full agenda for those attending EULAR 2025 in Barcelona with sessions on the management of RA, Behcets, Lupus and Hand Osteoarthritis. Clinical overviews on MAS, Ehlers-Danlos, Difficult to treat RA and PsA offered a wide variety of options to rheumatologists. Here are a few interesting presentations from today.
      EULAR Daily Recap: Day 1 and 2
      #EULAR2025 Abstr#OP0198 Long-term extension study of Phase 2 #SLE showed efficacy of Upadacitinib and UPA + Elsubrutinib

      Md Yuzaiful Md Yusof Yuz6Yusof

      4 months 2 weeks ago
      #EULAR2025 Abstr#OP0198 Long-term extension study of Phase 2 #SLE showed efficacy of Upadacitinib and UPA + Elsubrutinib were maintained through to Week 104. Those who switched from PBO at WK48 to UPA + ELSU also improved. No VTE or MACE. Is add-on ELSU really needed? @RheumNow https://t.co/x8NbAtsHh0
      Interesting debate today #EULAR2025 about medical cannabis - where relative harms have come up.

      Would you rather be add

      David Liew drdavidliew

      4 months 2 weeks ago
      Interesting debate today #EULAR2025 about medical cannabis - where relative harms have come up. Would you rather be addicted to prescription opioids or recreational cannabis? (not going to argue about cannabis addiction - let’s say social impact is equal) @RheumNow
      #Vagal #nerve #stimulation
      Hand held device
      #BDMARD failure
      Plausible - improved pro inflammatory cytokines

      wears off

      Janet Pope Janetbirdope

      4 months 2 weeks ago
      #Vagal #nerve #stimulation Hand held device #BDMARD failure Plausible - improved pro inflammatory cytokines wears off benefit if stopped Attenuates in ~half over yrs Open label uncontrolled @RheumNow @eular_org #EULAR2025 Session D2T-RA https://t.co/98K5gwasHv
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