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Rheumatoid Arthritis

      Should we still be worried about lymphoma developing in RA patients?

      Incidence has plummeted with modern therapy, altho

      David Liew drdavidliew

      4 months 2 weeks ago
      Should we still be worried about lymphoma developing in RA patients? Incidence has plummeted with modern therapy, although still a small risk. TNFi and other bDMARDs don’t seem to confer any real risk. So what should our approach be? Karin Hellgren #EULAR2025 @RheumNow https://t.co/9ZodpojSaz
      KORAIL cohort
      Prediction model for progression of RA-ILD at 3 years
      A combination of classic clinical parameters incl DA

      Aurelie Najm AurelieRheumo

      4 months 2 weeks ago
      KORAIL cohort Prediction model for progression of RA-ILD at 3 years A combination of classic clinical parameters incl DA , ILD pattern, ACPA KL-6 with AUC 0.75 HR=34 for progression in High risk group Need validation in an external cohort @RheumNow #EULAR2025 OP0329 https://t.co/LIvn1JCXPq
      New work presented at the 2025 annual EULAR congress in Barcelona focuses on the recombinant zoster vaccine (RZV), which contains recombinant glycoprotein E – the major target of CD4+T-cells. The abstract describes the tolerability and safety of RZV in patients with inflammatory rheumatic and musculoskeletal diseases (iRMD), showcasing interim data from an ongoing study.
      🎯 Early MTX hits the mark — but only in ACPA-negative.
      In TREAT EARLIER, 1 year of MTX led to lasting benefits at 5

      Jiha Lee JihaRheum

      4 months 2 weeks ago
      🎯 Early MTX hits the mark — but only in ACPA-negative. In TREAT EARLIER, 1 year of MTX led to lasting benefits at 5 years: ➖ Less RA ➖ Better function ❌ No benefit in ACPA+ Abstract#OP0324 @RheumNow #EULAR2025
      Is RA just one disease?

      No, & increasingly more efforts to subgroup RA on diff levels

      Simple approach - derived ph

      David Liew drdavidliew

      4 months 2 weeks ago
      Is RA just one disease? No, & increasingly more efforts to subgroup RA on diff levels Simple approach - derived phenotypes map (independent of ACPA): - to broad histopath - to MTX response Omics is good, but still need to do the simple stuff better! #EULAR2025 OP0328 @RheumNow https://t.co/a8Vl7Kcjso
      Is there a higher risk of cancer that comes with the disease? Or with the treatments? So many confounding parameters, such as disease duration, disease state, and disease activity come into play. A promising session explored comorbidities in Rheumatoid Arthritis, in particular cancer and cardiovascular events. Here are my takeaways.
      Day 2 was a full agenda for those attending EULAR 2025 in Barcelona with sessions on the management of RA, Behcets, Lupus and Hand Osteoarthritis. Clinical overviews on MAS, Ehlers-Danlos, Difficult to treat RA and PsA offered a wide variety of options to rheumatologists. Here are a few interesting presentations from today.
      #neuromodulation in #rheumatoid #arthritis

      What is it?
      👇
      Autonomic & immune system interaction

      Who seeks thi

      Janet Pope Janetbirdope

      4 months 2 weeks ago
      #neuromodulation in #rheumatoid #arthritis What is it? 👇 Autonomic & immune system interaction Who seeks this Rx? desperate pts w pain No Rx left Interested in technology #EULAR2025 @RheumNow @eular_org #D2T #RA https://t.co/XWWFiUK6Em
      #vagal & #splenic #nerves most studied
      In #immune #system interaction

      #PNS can detect #inflammation

      use in #D2T #

      Janet Pope Janetbirdope

      4 months 2 weeks ago
      #vagal & #splenic #nerves most studied In #immune #system interaction #PNS can detect #inflammation use in #D2T #RA w active disease ? Key factors in #neurostimulation - many #EULAR2025 @RheumNow @eular_org #D2T in #RA session https://t.co/tCgpGtI5z2
      #Vagal #nerve #stimulation
      Hand held device
      #BDMARD failure
      Plausible - improved pro inflammatory cytokines

      wears off

      Janet Pope Janetbirdope

      4 months 2 weeks ago
      #Vagal #nerve #stimulation Hand held device #BDMARD failure Plausible - improved pro inflammatory cytokines wears off benefit if stopped Attenuates in ~half over yrs Open label uncontrolled @RheumNow @eular_org #EULAR2025 Session D2T-RA https://t.co/98K5gwasHv
      #RCT of #vagus #nerve #stimulation in #bDMARD-IR #RA Pts

      RESSET RCT
      +RA #RCT w #VNS

      But low response with stat signif

      Janet Pope Janetbirdope

      4 months 2 weeks ago
      #RCT of #vagus #nerve #stimulation in #bDMARD-IR #RA Pts RESSET RCT +RA #RCT w #VNS But low response with stat significance ACR20 1/4 sham vs 1/3 VNS Would add on to new SoC? 🤔 #EULAR2025 @RheumNow #eular_org #D2T- RA-session https://t.co/tR1pLPBr74
      So we used to get taught about bimodal age distribution of RA onset - young people and old people.

      Actually, it’s ear

      David Liew drdavidliew

      4 months 2 weeks ago
      So we used to get taught about bimodal age distribution of RA onset - young people and old people. Actually, it’s early middle age where RA diagnoses have now grown globally over 30y - right in peak productivity Global Burden of Disease data #EULAR2025 OP0240-HPR @RheumNow https://t.co/8yyrex00yy
      cool stuff at #EULAR2025

      RESET #RCT - #vagal #nerve #stimulation #VNS vs sham in
      #RA w 1or >1 #bDMARD-IR
      N=242
      D/C

      Janet Pope Janetbirdope

      4 months 2 weeks ago
      cool stuff at #EULAR2025 RESET #RCT - #vagal #nerve #stimulation #VNS vs sham in #RA w 1or >1 #bDMARD-IR N=242 D/C bDMARD, on #csDMARD #RA 12 yrs, 10SJC 12TJC 2.6 b/tsDMARD failure Wk12 EULAR good/mod response 61v 42% Sham▶️goes VNS ✅data= @RheumNow @eular_org abst#OP190
      Connective tissue diseases (CTDs) and interstitial lung disease (ILD) represent a challenging intersection of systemic autoimmunity and progressive respiratory impairment. Research presented at EULAR 2025 continues to highlight the importance of CTD-ILD and the evolving landscape of therapeutic options for patients with autoimmune ILDs.
      #polyrefractory #RA
      =
      failed all classes in #rheumatoid #arthritis
      +inflammatory #arthritis
      Longer disease duration
      Lat

      Janet Pope Janetbirdope

      4 months 2 weeks ago
      #polyrefractory #RA = failed all classes in #rheumatoid #arthritis +inflammatory #arthritis Longer disease duration Late RA Rx +power Doppler in POCUS ⬆️no refractory BMI Fibromyalgia - pain ⬇️SJC, less DAS , rapid X-ray progression #EULAR2025 @RheumNow #D2T #RA https://t.co/1sPwf3Qa3m
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