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Rheumatoid Arthritis

      Should we still be worried about lymphoma developing in RA patients?

      Incidence has plummeted with modern therapy, altho

      David Liew drdavidliew

      10 months ago
      Should we still be worried about lymphoma developing in RA patients? Incidence has plummeted with modern therapy, although still a small risk. TNFi and other bDMARDs don’t seem to confer any real risk. So what should our approach be? Karin Hellgren #EULAR2025 @RheumNow https://t.co/9ZodpojSaz
      KORAIL cohort
      Prediction model for progression of RA-ILD at 3 years
      A combination of classic clinical parameters incl DA

      Aurelie Najm AurelieRheumo

      10 months ago
      KORAIL cohort Prediction model for progression of RA-ILD at 3 years A combination of classic clinical parameters incl DA , ILD pattern, ACPA KL-6 with AUC 0.75 HR=34 for progression in High risk group Need validation in an external cohort @RheumNow #EULAR2025 OP0329 https://t.co/LIvn1JCXPq
      New work presented at the 2025 annual EULAR congress in Barcelona focuses on the recombinant zoster vaccine (RZV), which contains recombinant glycoprotein E – the major target of CD4+T-cells. The abstract describes the tolerability and safety of RZV in patients with inflammatory rheumatic and musculoskeletal diseases (iRMD), showcasing interim data from an ongoing study.
      🎯 Early MTX hits the mark — but only in ACPA-negative.
      In TREAT EARLIER, 1 year of MTX led to lasting benefits at 5

      Jiha Lee JihaRheum

      10 months ago
      🎯 Early MTX hits the mark — but only in ACPA-negative. In TREAT EARLIER, 1 year of MTX led to lasting benefits at 5 years: ➖ Less RA ➖ Better function ❌ No benefit in ACPA+ Abstract#OP0324 @RheumNow #EULAR2025
      Is RA just one disease?

      No, & increasingly more efforts to subgroup RA on diff levels

      Simple approach - derived ph

      David Liew drdavidliew

      10 months ago
      Is RA just one disease? No, & increasingly more efforts to subgroup RA on diff levels Simple approach - derived phenotypes map (independent of ACPA): - to broad histopath - to MTX response Omics is good, but still need to do the simple stuff better! #EULAR2025 OP0328 @RheumNow https://t.co/a8Vl7Kcjso
      Is there a higher risk of cancer that comes with the disease? Or with the treatments? So many confounding parameters, such as disease duration, disease state, and disease activity come into play. A promising session explored comorbidities in Rheumatoid Arthritis, in particular cancer and cardiovascular events. Here are my takeaways.
      Day 2 was a full agenda for those attending EULAR 2025 in Barcelona with sessions on the management of RA, Behcets, Lupus and Hand Osteoarthritis. Clinical overviews on MAS, Ehlers-Danlos, Difficult to treat RA and PsA offered a wide variety of options to rheumatologists. Here are a few interesting presentations from today.
      #neuromodulation in #rheumatoid #arthritis

      What is it?
      👇
      Autonomic & immune system interaction

      Who seeks thi

      Janet Pope Janetbirdope

      10 months ago
      #neuromodulation in #rheumatoid #arthritis What is it? 👇 Autonomic & immune system interaction Who seeks this Rx? desperate pts w pain No Rx left Interested in technology #EULAR2025 @RheumNow @eular_org #D2T #RA https://t.co/XWWFiUK6Em
      #Vagal #nerve #stimulation
      Hand held device
      #BDMARD failure
      Plausible - improved pro inflammatory cytokines

      wears off

      Janet Pope Janetbirdope

      10 months ago
      #Vagal #nerve #stimulation Hand held device #BDMARD failure Plausible - improved pro inflammatory cytokines wears off benefit if stopped Attenuates in ~half over yrs Open label uncontrolled @RheumNow @eular_org #EULAR2025 Session D2T-RA https://t.co/98K5gwasHv
      #RCT of #vagus #nerve #stimulation in #bDMARD-IR #RA Pts

      RESSET RCT
      +RA #RCT w #VNS

      But low response with stat signif

      Janet Pope Janetbirdope

      10 months ago
      #RCT of #vagus #nerve #stimulation in #bDMARD-IR #RA Pts RESSET RCT +RA #RCT w #VNS But low response with stat significance ACR20 1/4 sham vs 1/3 VNS Would add on to new SoC? 🤔 #EULAR2025 @RheumNow #eular_org #D2T- RA-session https://t.co/tR1pLPBr74
      So we used to get taught about bimodal age distribution of RA onset - young people and old people.

      Actually, it’s ear

      David Liew drdavidliew

      10 months ago
      So we used to get taught about bimodal age distribution of RA onset - young people and old people. Actually, it’s early middle age where RA diagnoses have now grown globally over 30y - right in peak productivity Global Burden of Disease data #EULAR2025 OP0240-HPR @RheumNow https://t.co/8yyrex00yy
      cool stuff at #EULAR2025

      RESET #RCT - #vagal #nerve #stimulation #VNS vs sham in
      #RA w 1or >1 #bDMARD-IR
      N=242
      D/C

      Janet Pope Janetbirdope

      10 months ago
      cool stuff at #EULAR2025 RESET #RCT - #vagal #nerve #stimulation #VNS vs sham in #RA w 1or >1 #bDMARD-IR N=242 D/C bDMARD, on #csDMARD #RA 12 yrs, 10SJC 12TJC 2.6 b/tsDMARD failure Wk12 EULAR good/mod response 61v 42% Sham▶️goes VNS ✅data= @RheumNow @eular_org abst#OP190
      Connective tissue diseases (CTDs) and interstitial lung disease (ILD) represent a challenging intersection of systemic autoimmunity and progressive respiratory impairment. Research presented at EULAR 2025 continues to highlight the importance of CTD-ILD and the evolving landscape of therapeutic options for patients with autoimmune ILDs.
      #polyrefractory #RA
      =
      failed all classes in #rheumatoid #arthritis
      +inflammatory #arthritis
      Longer disease duration
      Lat

      Janet Pope Janetbirdope

      10 months ago
      #polyrefractory #RA = failed all classes in #rheumatoid #arthritis +inflammatory #arthritis Longer disease duration Late RA Rx +power Doppler in POCUS ⬆️no refractory BMI Fibromyalgia - pain ⬇️SJC, less DAS , rapid X-ray progression #EULAR2025 @RheumNow #D2T #RA https://t.co/1sPwf3Qa3m
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