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      Progress of biologics/targeted therapy in SLE

      We are in a transformative era for SLE, for clinicians and patients. Fou

      Dr. John Cush RheumNow

      1 week ago
      Progress of biologics/targeted therapy in SLE We are in a transformative era for SLE, for clinicians and patients. Four targeted therapies are now licensed: belimumab (nephritis and non‑renal), voclosporin and obinutuzumab (nephritis), and anifrolumab (non‑renal). Many agents https://t.co/BuFCmj1hQd
      @RheumNow HOT #Obesity session (7)

      📢A call for action
      Current RMD treatments ignore obesity:
      They all target immune

      Nelly ZIADE 🍀 Nellziade

      1 week ago
      @RheumNow HOT #Obesity session (7) 📢A call for action Current RMD treatments ignore obesity: They all target immune response but miss the metabolic-inflammatory loop Breaking that cycle may be the missing piece Obesity must be part of every rheumatology plan #EULAR2026 @rheumnow
      ☂️What is an umbrella meta-analysis?
      It's a meta-analysis of meta-analyses ☔️

      ⬇️This one showed the effect

      Nelly ZIADE 🍀 Nellziade

      1 week ago
      ☂️What is an umbrella meta-analysis? It's a meta-analysis of meta-analyses ☔️ ⬇️This one showed the effect of diet supplementation on several RA outcomes Unfortunately, most studies have low levels of evidence #umbrella #rainy_London #EULAR2026 @rheumnow https://t.co/kYPchXEexn
      🔥 TOGETHER-PsA (OP069) #EULAR2026 #EULARbestIxekizumab + Tirzepatide vs IXE alone in PsA with obesity/overweight:?

      Nelly ZIADE 🍀 Nellziade

      1 week ago

      🔥 TOGETHER-PsA (OP069) #EULAR2026 #EULARbest Ixekizumab + Tirzepatide vs IXE alone in PsA with obesity/overweight: ✅ Primary endpoint (ACR50 + ≥10% wt loss at W36): 31.7% vs. 0.8% (p<0.001) ✅ ACR50: 33.5% vs. 20.4% ✅ MDA: 26.3% vs. 15.3% (p=0.026) @rheumnow @DrLauraCoates https://t.co/6wh3S6khXw

      Ivarmacitinib (selective JAK1 inhibitor) significantly improved ASAS40 vs placebo in nr-#axSpA(39.7% vs 24.8%; p=0.006)

      Antoni Chan MD (Prof) synovialjoints

      1 week ago
      Ivarmacitinib (selective JAK1 inhibitor) significantly improved ASAS40 vs placebo in nr-#axSpA(39.7% vs 24.8%; p=0.006) at 12 weeks, sustained to 24 weeks. Another oral option for non-radiographic disease. Abstr OP0237 @RheumNow #EULAR2026
      DR JOHN STONE gives Overview
      Of
      #IgG4

      New non B cell depleter
      #obexelimab N=194 in RCT

      To add to B cell depletion w

      Janet Pope Janetbirdope

      1 week ago
      DR JOHN STONE gives Overview Of #IgG4 New non B cell depleter #obexelimab N=194 in RCT To add to B cell depletion w #Inebilizumab Off label but used also #Rituximab #steroids #Immunesuppressives Other investigational drugs Ex #JAKi #EULAR2026 @RheumNow #OP018 #RULARbest https://t.co/Y4saGYcdww
      Presented at EULAR 2026 London, Brepocitinib dual TYK2/JAK1 inhibitor with successful Phase 3 VALOR trial demonstrating significant improvement in skin and muscle symptoms in dermatomyositis (DM).
      🔬 Can baseline T cell phenotype predict PsA treatment response?

      COLIPSO cohort (n=17): YES!

      Higher Treg & act

      Nelly ZIADE 🍀 Nellziade

      1 week ago
      🔬 Can baseline T cell phenotype predict PsA treatment response? COLIPSO cohort (n=17): YES! Higher Treg & activated CD4+ cells predict DAPSA & joint improvement #POS0083 #EULAR2026 @RheumNow https://t.co/UIs6LXAWAY
      🧬 Does spine vs knee enthesis differ immunologically?

      Translational scRNAseq study: YES!

      Spine produces more IL-2

      Nelly ZIADE 🍀 Nellziade

      1 week ago
      🧬 Does spine vs knee enthesis differ immunologically? Translational scRNAseq study: YES! Spine produces more IL-23 but shows attenuated IL-17 response vs knee #POS0084 #EULAR2026 @RheumNow https://t.co/itFrLEXSzZ
      🔍 Are 2025 ASAS-SPARTAN criteria valid in early axSpA?

      SPACE cohort (n=669):

      HIGH specificity (97.5%) but LOWER s

      Nelly ZIADE 🍀 Nellziade

      1 week ago
      🔍 Are 2025 ASAS-SPARTAN criteria valid in early axSpA? SPACE cohort (n=669): HIGH specificity (97.5%) but LOWER sensitivity (60%) vs 2009 criteria (83%) #OP0239 #EULAR2026 @RheumNow https://t.co/9wNbtcbP0l
      A Field Whose Time Has Come: Launching the EULAR Study Group on Geriatric Rheumatology

      EULAR launches a Study Group on

      Dr. John Cush RheumNow

      1 week ago
      A Field Whose Time Has Come: Launching the EULAR Study Group on Geriatric Rheumatology EULAR launches a Study Group on Geriatric Rheumatology — clinics increasingly serve older patients with multimorbidity, polypharmacy, frailty, cognitive and functional limits, yet research
      🎗️ Do targeted therapies raise cancer risk in SpA?
      French nationwide cohort (n=56,591): NO

      In fact, prolonged exp

      Nelly ZIADE 🍀 Nellziade

      1 week ago
      🎗️ Do targeted therapies raise cancer risk in SpA? French nationwide cohort (n=56,591): NO In fact, prolonged exposure REDUCES risk (wHR 0.86), especially haematological. #OP0238 #EULAR2026 @RheumNow https://t.co/dDveAmWpdX
      💉 Does ivarmacitinib (selective #JAK1i work in nr-axSpA?

      Phase 3 RCT (n=304):
      ASAS40 39.7% vs 24.8% placebo at wee

      Nelly ZIADE 🍀 Nellziade

      1 week ago
      💉 Does ivarmacitinib (selective #JAK1i work in nr-axSpA? Phase 3 RCT (n=304): ASAS40 39.7% vs 24.8% placebo at week 12 with sustained benefit at week 24 #OP0237 #EULAR2026 @RheumNow https://t.co/kofXnPp6qQ
      Window of opportunity in stills disease is early. With IL1 / IL6 agents
      #sJIA and #AOSD are the same disease. - may need

      Bella Mehta bella_mehta

      1 week ago
      Window of opportunity in stills disease is early. With IL1 / IL6 agents #sJIA and #AOSD are the same disease. - may need a standard new crieteria IL18 measuremnet should be encouraged. @RheumNow #EULAR2026 plenary https://t.co/EQbs9mDYjS
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