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      Methotrexate (MTX) remains the cornerstone of rheumatoid arthritis (RA) treatment, yet it remains unclear as to how to predict who will respond to it. Two studies presented at ACR (Abstracts 2639 and 2643) suggest the answer may be hiding in the gut.
      IgG4: Rare but Treatable!
      Tweeting about an ACR presentation or poster is a skill and sometimes art -- one that is mastered by the RheumNow faculty roving the halls and floors for the best new insights at ACR Convergence 2025.  Below are several of the best abstracts from Day 3, as chosen by our outstanding faculty.
      At ACR 2025, the session “27M02: Nutrition for Rheumatic Disease: Where Aging Biology, Sarcopenia, and Diet Intersect” invited the audience to view rheumatic disease through the lens of biological aging and to consider how nutrition and exercise can serve as integrative lifestyle interventions.
      A deep dive into Lupus 🔬
      Abstract 2601: Single-cell insights in SLE & pre-clinical autoimmunity
      🔹 Plasmablast

      Akhil Sood MD, MS AkhilSoodMD

      1 week 1 day ago
      A deep dive into Lupus 🔬 Abstract 2601: Single-cell insights in SLE & pre-clinical autoimmunity 🔹 Plasmablast expansion → high disease activity & SLE risk 🔹 Metabolic activity varies by cell type 🔹 Established disease: ↑ glycolysis & OxPHOS changes @RheumNow #ACR25
      Head to head study of Secukinumab vs Ustekinumab. In TNFi-experienced PsA patients, the AgAIN trial shows secukinumab pe

      Antoni Chan MD (Prof) synovialjoints

      1 week 1 day ago
      Head to head study of Secukinumab vs Ustekinumab. In TNFi-experienced PsA patients, the AgAIN trial shows secukinumab performed better than ustekinumab in HAQ-DI response (57.1% vs 27.0%, p=0.002) and across all endpoints (joint counts, pain, and skin outcomes). Fewer https://t.co/CDCWkLF5TW
      Abstract 2360: Single-center lupus pregnancy cohort found that:
      🔹 Absence of DORIS remission associated w/ adverse pr

      Akhil Sood MD, MS AkhilSoodMD

      1 week 1 day ago
      Abstract 2360: Single-center lupus pregnancy cohort found that: 🔹 Absence of DORIS remission associated w/ adverse pregnancy outcomes (Pre-term, Pre-eclampsia) 🔹 This is along with known risk factors: antihypertensive use, prior nephritis, active disease @RheumNow #ACR25 https://t.co/STg1NBeFPo
      CDAI appropriately guided therapy escalation in RA, but not for everyone. Treatment adjustments were less likely in pts

      Jiha Lee JihaRheum

      1 week 1 day ago
      CDAI appropriately guided therapy escalation in RA, but not for everyone. Treatment adjustments were less likely in pts with public or no insurance. Even data-driven care can fall short when access barriers persist. @RheumNow #ACR25 Abstract#2616
      Reaadmissions in sle pregnancies from 66k patients
      Insurance and economics seem to be very important in predictions usin

      Bella Mehta bella_mehta

      1 week 1 day ago
      Reaadmissions in sle pregnancies from 66k patients Insurance and economics seem to be very important in predictions using machine learning. Abst#2629 #ACR25 @RheumNow https://t.co/x2oo9TOxoh
      In healthy women, preeclampsia was more common with:
      - increased calprotectin
      - decreased anti-CCP (very low levels)
      dur

      David Liew drdavidliew

      1 week 1 day ago
      In healthy women, preeclampsia was more common with: - increased calprotectin - decreased anti-CCP (very low levels) during pregnancy & this has good predictive capacity for future preeclampsia. Rheum pathophys can give insights into adjacent pathology #ACR25 ABST2628 @RheumNow https://t.co/7d5YB6n6XJ
      In a retrospective TrinetX analysis of 3 year safety outcome in AS, JAKi use was linked to higher mortality and GI bleed

      Antoni Chan MD (Prof) synovialjoints

      1 week 1 day ago
      In a retrospective TrinetX analysis of 3 year safety outcome in AS, JAKi use was linked to higher mortality and GI bleeding vs TNFi, but lower malignancy risk. Infection rates were similar, with a trend toward more herpes zoster in JAKi users. Abstract#2633 @RheumNow #ACR25 https://t.co/pPY0wpAKA3
      DMARD exposure overall during pregnancy is not associated with severe maternal or neonatal morbidity, in this Ontario co

      David Liew drdavidliew

      1 week 1 day ago
      DMARD exposure overall during pregnancy is not associated with severe maternal or neonatal morbidity, in this Ontario cohort. We’re getting better at finding a balance with DMARDs that is safe for both mother and baby. Blanket resistance is harmful #ACR25 ABST2627 @RheumNow https://t.co/oDOpySGS3N
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