Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com.
In difficult times, it's reassuring to reflect on the similarities that bring us together. In the case of the EULAR and ACR COVID19 guidelines as discussed at #EULAR2020 by Drs. Mikuls and Landewe, the recommendations from both panels proved to be reassuring with a hint of "we are flying blindly into the unknown."
Dr. John Cush RheumNow
4 years 6 months ago
Tofacitinib shown to be effective (vs Placebo) in 225 Polyarticular JIA (included some ERA & PsA). with less flares (29 vs 53%) and higher JCR30 responses (71 vs 47%) @6mos #EULAR2020 #OP0281 https://t.co/3BnZeB4ROr https://t.co/4pTLbTtBdN
Dr. John Cush RheumNow
4 years 6 months ago
CDC guidelines for Rx of Latent Tuberculosis; Preferred: A) 3 months of once-weekly INH plus rifapentine (3HP); B) 4 months of daily rifampin (4R); C) 3 months of daily INH plus rifampin (3HR) - Shorter, safer, effective with higher completion rates. https://t.co/a2iZczFTP2
Dr. John Cush RheumNow
4 years 6 months ago
Lancet has issued an almost retraction - an "Expression of Concern" alerting readers that many have voiced scientific concerns about the Lancet HCQ/CQ paper w/ more deaths. MORE DEATHS COULD HAVE BEEN FROM THE DRUGS OR THE DRUGS BEING USED IN SICKER PTS https://t.co/saoE32qpuF
A Lancet systematic review and meta-analysis provides the basis for physical distancing and the value of making as measures to prevent infection with coronavirus 2 (SARS-CoV-2) or COVID-19.
The analysis included 172 observational studies, no randomised controlled trials and 44 relevant comparative studies involving 25 697 patients.
NEJM has reported that the use of hydroxychloroquine did not prevent symptomatic COVID-19 infection when used within 4 days after SARS-CoV-2 exposure.
Currently for persons who are COVID exposed, the standard of care is quarantine and there is no known preventative therapy.
Dr. John Cush RheumNow
4 years 6 months ago
Open label, uncontrolled study shows that background use of azathioprine (2mg/kg) in Pegloticase treated refractory gout patients was partly effective - 6/12 completed, 2 still on Rx, 2 PEG ineffective and 2 side effx #EULAR2020 #Gout Abst#THU0410 https://t.co/APZRPCQUFg https://t.co/Nfsq4QjyA5
Mario Pompermayer, MD pompermarioMD
4 years 6 months ago
Use of HCQ was not associated with development of ❤️Heart Failure in patients with RA. There was no statistically significant association between the cumulative dose of HCQ & HF. A good study from #MayoClinic. #EULAR2020 #eular20 https://t.co/yG03e0TAcV
Janet Pope Janetbirdope
4 years 6 months ago
ILD RA has more hospital admissions. Occurs in 14% of RA. Increased mortality. Serious complication of RA @eular_org @RheumNow @CRASCRRheum @earlyarthritis #EULAR2020 OP0039 https://t.co/2N3tulzq3R
Janet Pope Janetbirdope
4 years 6 months ago
Nice surprise as IL23 Guselkumab works not only in PsA but axial PsA. Another Rx option also presented at @eular_org #EULAR2020 @CRASCRRheum @earlyarthritis https://t.co/dUqqagzbeC
Janet Pope Janetbirdope
4 years 6 months ago
Can machine learning/AI predict who will respond & get remission in RA prior to bDMARD? High dose steroids, older age high ESR long disease duration worse outcomes but not same for each drug. OP0023 @eular_org #EULAR2020 @RheumNow @CRASCRRheum @earlyarthritis https://t.co/oNXDVQbzMC
David Liew drdavidliew
4 years 6 months ago
We're still poor at estimating the chance of remission with bDMARDs for individuals w RA - but maybe AI can help provide them with a personalised prediction of their chances of success? Remission predicted here w 57-73% accuracy.
Korean national data OP0023 #EULAR2020 @RheumNow https://t.co/zNw3j5VZni
David Liew drdavidliew
4 years 6 months ago
Tocilizumab in GCA - three year data from GiACTA on steroid exposure and time to flare:
- steroid-sparing benefit persists in both new-onset and relapsing disease
- in avoiding flares, benefit for weekly dosing in both new-onset and relapsing disease
OP0027 #EULAR2020 @RheumNow https://t.co/tGU6ayglHW
Dr. Rachel Tate uptoTate
4 years 6 months ago
"It's a brave new world!" Dr. Iain McInnes, president of #EULAR2020 discussing how the pandemic has created a "technological miracle" by bringing us all virtually together! @RheumNow
Poster Hall