Rheumatoid Arthritis
TheDaoIndex KDAO2011
3 years 5 months ago
Screen for depression in RA patients!
From the #DANBIO registry of 11,000 pts, they found
6X ⬆️mortality in pts w/#RA and #depression . The mortality curve separates early. #Plenary OP0067 @rheumnow #EULAR2022 https://t.co/qfjyejGVzQ
Eric Dein ericdeinmd
3 years 5 months ago
#EULAR2022 POS0241 shows JAKi ⬇️ pain catastrophization/central sensitization in RA patient via CSI (Central Sensitization Inventory) and (PCS) Pain Catastrophizing Scale.
No decrease of articular inflammation on ultrasound with JAKi shown, but study had just 22 pts
@RheumNow
Eric Dein ericdeinmd
3 years 5 months ago
#EULAR2022 OP0066
French retrospective obs study 2019-2021 with 73 cases of Whipples disease treated for rheum disease
▶️M/F ratio 3, middle aged
▶️1/2 met RA criteria
▶️Peripheral jts, 1/3 had axial involvement
▶️Rx: HCQ, Doxi - 80% cured, DMARD stopped in >90% cases
@RheumNow https://t.co/t7zlDrPfJB
Richard Conway RichardPAConway
3 years 5 months ago
NORD-STAR results. Biologic + MTX combo seemed better than slightly strange "conventional"(ACT) group of MTX + oral steroids or triple therapy + IA injections @RheumNow #EULAR2022 OP0058 https://t.co/tOfTlcplFR https://t.co/CvtvuVn5Xj
Eric Dein ericdeinmd
3 years 5 months ago
#EULAR2022 POS0235: Filgotinib Safety in RA for Median 2.2 years:
▶️No new safety concerns from 2020 report with shorter f/u
▶️Adverse events stable, or decreased, from early studies
@Rheumnow https://t.co/DO15Tqim4n
Eric Dein ericdeinmd
3 years 5 months ago
@Rheumnow #EULAR2022 POS0240
▶️ In 2021, 73.6% of Belgian RA patients staring a JAKi, started a 2nd generation JAKi (UPA, FIL).
Predictors for 1st generation usage (BAR, TOFA): older age, prior DMARD therapies.
What would you start as a first JAKi?
Janet Pope Janetbirdope
3 years 5 months ago
Household Cleaning is dirty business at least if you have #rheumatoid #arthritis as silica exposure from laundry and cleaning products were associated with RA ILD. #EULAR opening day. #ClinicalPearl #EULAR2022 @RheumNow #OP0006 https://t.co/OJQMy9Fe9m
Eric Dein ericdeinmd
3 years 5 months ago
ACR21: conditionally recommends against steroids with starting csDMARD
#EULAR2022 recommends with rapid GC dose reduction and discontinuation
Which is better recommendation?
@RheumNow
TheDaoIndex KDAO2011
3 years 5 months ago
#EULAR2022 RA updated reccs w/ minor changes: start MTX+GC, reduce GC rapidly, JAKi are recc only for pts w/o risk factors for CV or malignant dz (not sure I agree with this last one if the JAKi is the best drug for the pt and there are little options avail) @rheumnow https://t.co/CXyyCi6LVI
Eric Dein ericdeinmd
3 years 5 months ago
After the #EULAR2022 Recommendations session, it begs the question - Do we follow it?
In Germany, the answer is sometimes
Early bDMARD or JAKi is more frequent in recent years. 1/3 of patients did not receive recommended treatment escalation after 1st csDMARD
POS0234 @Rheumnow https://t.co/0DaP5b7Htc
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