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Dr. John Cush RheumNow
2 years 9 months ago
Anti-CD19 CAR T cell therapy for refractory #SLE published in Nature Medicine. 5 pts (22yrs) w/ refractory dz, active SLE (SLEDAI=16). Autologous pt T cells transduced to CD19 CAR Tcells, and lead to remission in 5/5 w/in 3 mos & maintained median 8 mos https://t.co/0epnffCNEN https://t.co/IMRzhOzgei
The big news this week: the approval of deucravacitinib (a new class of drug?) for psoriasis; the 2022 ACR guidance on glucocorticoid-induced osteoporosis; a national poll of older adults over the age of 50 who claimed self-reported or doctor-diagnosed arthritis; and much more. Let's review these and other news, journal reports and announcements from this past week.
Dr. John Cush RheumNow
2 years 9 months ago
Lupus (LUMEN) registry of 440 SLE compared to non-SLE pts, shows lupus pts have less screening for cervical cancer (HR 0.75), but SLE has more screening for HTN (HR 1.35), DM (HR 2.46), hyperlipidemia (HR 3.19) & Influenza & pneumovax vaccines https://t.co/e5ZGJswVds https://t.co/WQmhM0OZgl
Dr. John Cush RheumNow
2 years 9 months ago
Open label, noninferiority study TNFi withdrawal in 64 PsA & 58 axSpA pts. 2/3 tapered by dz activity T2T strategy (N=81) & 1/3 continued TNFi. At 12 mos. LDA seen in 69% w/ Tapering (~avg 53% dose) vs 73% no-tapering group (91% dose) https://t.co/K6WFaesyRt https://t.co/zqo6nVGtqW
Dr. John Cush RheumNow
2 years 9 months ago
Ischemic Forearm Exercise Test - used by McArdle, notes absence of elevated blood lactate levels during exercise w/ myophosphorylase deficiency (McArdle Dz). Deficiency impairs impairs glycogen metabolism & Nl lactate production in muscle https://t.co/t4PS1ghj5d https://t.co/YUDM1GCOfn
Dr. John Cush RheumNow
2 years 9 months ago
534 PsA & 470 AS pts (SERENA study) on Secukinumab for avg of ~88wks - 5.8% PsA & 8.9% AS pts had sudden stop of SEC (for avg ~25wks) (reasons? Mostly AE 58% or pt decision 10%). While TJC & SJC increased, dz control returned w/ restarting SEC https://t.co/GFxj3b06Ra https://t.co/B2ubakq8Ql
Findings of a new study suggest a causal effect between inflammatory bowel disease (IBD) and psoriasis (PSO) as well as psoriatic arthritis (PsA), but not vice versa.
A systematic review suggests that low-dose methotrexate (MTX) use is associated with an increased melanoma risk, but the absolute risk increase could be considered negligible.
Dr. John Cush RheumNow
2 years 9 months ago
2022 Univ of Michigan Natl Poll on Healthy Aging finds that 70% of older adults reported joint pain (more in Women 75% vs 65%M). 30% have a HCP dx of #OA, 8% RA, 7% gout or pseudogout & 5% w/ another kind of arthritis
https://t.co/yno8RgCRQS https://t.co/yTMLHsbGOU
Healio Rheumatology HealioRheum
2 years 9 months ago
New York is the best state for patients with #rheumatic diseases to live in, while Wyoming was ranked worst in the United States #RheumTwitter
https://t.co/ulYd0uNKZO
Donald Thomas, MD lupuscyclopedia
2 years 9 months ago
I just posted "Free Lupus Encyclopedia Book give away ... register to win... even international addresses are welcome" on Reddit
https://t.co/Pa4h75vcW1
Dr. John Cush RheumNow
2 years 9 months ago
New download available!
COVID Deaths at 3 Mos vs. 30 Mos
https://t.co/SLGJGh5NX1 https://t.co/QhWdvNHntk
The ACR has updated this guideline and includes recommendations on abaloparatide (PTHrP) and romosozumab, which are newly available since the ACR’s 2017 GIOP guideline.
Dr. Beth Wallace and colleagues at the University of Michigan surveyed a national sample of older adults (50–80 yrs) and found that 70% currently report experiencing joint pain and 60% reported being told by a health care professional that they have arthritis.
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