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Novel Rx

      Cohort from Netherlands 400+ PsA pts IR first bioDMARD
      300+ switched TNFi->IL-17i, 99 cycled TNFi->TNFi
      3year rete
      2 weeks 4 days ago
      Cohort from Netherlands 400+ PsA pts IR first bioDMARD 300+ switched TNFi->IL-17i, 99 cycled TNFi->TNFi 3year retention rates 12 mo 75% cyclers 80% swappers 24mo 60% cyclers 56% swappers No difference in treatment failure or DAS28 CRP #EULAR2024 @RheumNow POS0278 https://t.co/J8ONjVAFqG
      #EULAR2024 OP0193 Watch out, blinatumomab will BiTE! Bi-specific T-cell engagers (BiTEs), kill Bcells by engaging Tcells
      2 weeks 4 days ago
      #EULAR2024 OP0193 Watch out, blinatumomab will BiTE! Bi-specific T-cell engagers (BiTEs), kill Bcells by engaging Tcells. In 6 refractory #RA patients (failed 3 x ts/bDMARDs), deep blood & tissue depletion were met, good response. Brief raised temp but no cytokine storm @RheumNow https://t.co/OmxSbTXfZq
      RA patients on abatacept have an appalling immunogenic response to Shingrix. Humoral fades away in the first year, and a
      2 weeks 4 days ago
      RA patients on abatacept have an appalling immunogenic response to Shingrix. Humoral fades away in the first year, and an absence of cellular responses. Alarming and need strategies to combat this #EULAR2024 POS0620 Winthrop/@RADoctor @RheumNow https://t.co/8gY9ocLBDp
      #opportunistic inf in #autoimmune dz
      ๐ŸŽค @khyrich
      ๐Ÿ‘‰#herpes zost is โฌ†๏ธโฌ†๏ธ,esp๐Ÿ˜ณ#lupus (๐Ÿ’‰ >18yo๐Ÿ‡บ?
      #opportunistic inf in #autoimmune dz ๐ŸŽค @khyrich ๐Ÿ‘‰#herpes zost is โฌ†๏ธโฌ†๏ธ,esp๐Ÿ˜ณ#lupus (๐Ÿ’‰ >18yo๐Ÿ‡บ๐Ÿ‡ธ) ๐Ÿ‘‰#HBV react โฌ†๏ธโฌ†๏ธ w/ RTX (9.1%) >>TNFi, JAKi, IL-6 ๐Ÿ‘‰ ๐Ÿ™…โ€โ™‚๏ธ #TB repeat ๐Ÿงช on #DMARD if ๐Ÿšซnew risk fact/gapโš ๏ธ ๐Ÿ”—#eular 2022 guide: https://t.co/PIpGpTrH28 #eular2024 #rheumx @RheumNow https://t.co/kouXvradiC
      Cycle or swap 2? Post failure to a first TNFi in patients with PsA, there was no difference in cycle versus swap to IL17
      2 weeks 4 days ago
      Cycle or swap 2? Post failure to a first TNFi in patients with PsA, there was no difference in cycle versus swap to IL17i for drug retention rate or disease activity. In male PsA patients a cycle strategy had a longer drug retention rate compared to a swap (IL-17i) strategy.โ€ฆ https://t.co/5BykvDwFWV https://t.co/GfcnIltV2A
      Multi-modal analysis of rheumatoid arthritis (RA) synovitis pathotypes enables more accurate choices of first line cDMARDs treatment, suggesting a predictive value to synovial biopsy. Theโ€ฆ