JAK/TYK2
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3 weeks 4 days ago
OP0086 #EULAR2024 @RheumNow #EULARBest
Pain & remission/low disease activity at 3m in pts with #RA in RA-BE-REAL
Pts taking #baricitinib more likely to achieve pain control vs TNFi/other mode of action
1/2 pts achieving remission/LDA & had bari achieved ≥70% pain relief.
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3 weeks 4 days ago
Ph III RCT SHR0302 JAK1 selective inhibitor in RA
500+ pts
ACR20 wk 24 SHR0302 8mg & 4mg PBO 75% 70% 40%
ACR70 wk 24 SHR0302 8mg & 4mg PBO 31% 22% 7%
Safety similar other JAKi
Abstr#OP0037 #EULAR24 @RheumNow https://t.co/6ZuvT6czo8
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3 weeks 4 days ago
OP0048 Impressive CLASI (lupus skin index score) with #deucravacitinib - data presented by Dr C Arriens #EULAR24 @RheumNow #WiR https://t.co/EuQdwuolN6
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3 weeks 4 days ago
Substudy of SELECT-COMPARE trial
Week 60 immunogenicity RZV RA treated UPA 15 mg + MTX
✔️ HUmorale response 71%
✔️ Cellular response 65%
✔️ No serious AEs
✔️ One event of HZ occurred during follow up
Abstr#OP0020 #EULAR2024 @RheumNow https://t.co/8OMwGuIZFx
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3 weeks 4 days ago
I chaired great debate at #EULAR2025 - JAK Inhibitor Special Warnings: can observational data debunk an RCT? Drs Janet Pope(NO) vs David Liew(YES). Voting suggests most are concerned about JAK warnings, but Liew won by converting a minority his way @janetbirdope @Drdavidliew https://t.co/bV1JdO7c4e
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3 weeks 4 days ago
EULAR 2024 kicked off with a fantastic debate between Janet Pope and David Liew - ‘JAK inhibitor special warnings: Can observational data debunk an RCT?’
A thought-provoking discussion summarising all aspects of the ongoing conversation on JAKi use in high-risk patients! https://t.co/MzW3jSSCfr
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3 weeks 4 days ago
More data from Jak-pot, the real-world multinational RA study, this time looking at infection in 14 national registries
JAKi (vs TNFi) had no signal for general/serious infection (excluding HZ)
Somewhat reassuring post-ORAL Surveillance infection data
#EULAR2024 OP0092 @RheumNow https://t.co/ocAbc4NiV2
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3 weeks 4 days ago
Shingrix in upadacitinib + MTX RA, in SELECT-COMPARE RCT:
data now out to 60w
good humoral and cellular response in most, even without MTX withheld
(& good safety too)
Important for our JAKi-treated patients to get the protection they need #EULAR2024 OP0020 @RheumNow https://t.co/FqVCCwUJOg
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3 weeks 4 days ago
@Janetbirdope @RheumNow #EULAR2024 JAK-i Debate
@drdavidliew (NOT in support of regulation)
- is the signal real? Query about replicability & data came from N. America. Not reflected on real-world data of enriched cohorts
- is the warning justified?
- are there unintended consequences?
@RheumNow https://t.co/TXUf90fqwN
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