So how do we get from slightly increased numbers of uncommon events in a single study (ORAL Surveillance)? Regulators think differently to us, which partly is the difficulty of a restrictive warning. So being the Aussie I am, I asked - does it pass the 'pub test'? 4/ #EULAR2024 https://t.co/Ih9H87wH22

• https://twitter.com/drdavidliew/status/1801144553241797037/photo/1
• https://twitter.com/drdavidliew/status/1801144553241797037/photo/1
• https://twitter.com/drdavidliew/status/1801144553241797037/photo/1
• https://twitter.com/drdavidliew/status/1801144553241797037/photo/1

What happens when RA patients only on csDMARDs want to stop their meds? in BIO-FLARE, only half flared within 6mo of stopping all csDMARDs suddenly. They’ve got a clinical predictive model. Many milder patients ask, and could benefit! #EULAR2024 POS0068 John Isaacs @RheumNow https://t.co/B7ZjP5Pj70

• https://twitter.com/drdavidliew/status/1801238719917072398/photo/1
• https://twitter.com/drdavidliew/status/1801238719917072398/photo/1

Risk of developing RA increased in antibody double-positive and single-positive compared to seronegative individuals. Highest risk in double-positive in first year. Single-positive increased risk of RA for up to five years after testing. In double-positive the risk remained… https://t.co/XLDHK4d4AE https://t.co/3Ek8knGExU

• https://twitter.com/i/web/status/1801236024099487785
• https://twitter.com/synovialjoints/status/1801236024099487785/photo/1

OP0201- clinical characteristics of pts failing ≥2 b/tsDMARDs D2T RA pts characterised by ⏰ Earlier disease ⏰ Later initiation of DMARD therapy Discontinuation of drugs mainly due to inefficacy regardless of number of drug lines or MOAs used #EULAR2024 @RheumNow

OP0140-When should we give #pneumococcal #vaccine to pts starting MTX? Study in RA:PCV13 vaccine given 1 month BEFORE starting MTX leads to higher immunological response at 1m, vs pts vaccinated simultaneously w MTX ⏩Vaccinate patients before starting MTX! @RheumNow #EULAR2024

When patients say their joints are swollen, what does it mean? Easy to dismiss it as a symptom, but this clinically suspect arthralgia cohort from Leiden shows: - some correlation with MRI/USS findings - predicts RA development still worthwhile! #EULAR2024 POS0609 @RheumNow https://t.co/dw2p5Eo26C

• https://twitter.com/drdavidliew/status/1801220393036038147/photo/1

We’ve got better at treating RA over the last 20 years, and it’s genuinely saving lives. Something to be very proud of. Let’s not forget that! 5y mortality from DANBIO 🇩🇰 (still, we still have work to do in seropos RA in men!) #EULAR2024 OP0162 @RheumNow https://t.co/RfvABXhPvS

• https://twitter.com/drdavidliew/status/1801183966709628934/photo/1

#EULAR2024 @RheumNow https://t.co/nXpDI52R2U

• https://twitter.com/DrMiniDey/status/1801187162534052223/photo/1