Conference Perspectives

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      I was allocated to bring down the warning, & I did apologise up front to both the EMA and Janet #EULAR2024. It's a t

      David Liew drdavidliew

      3 months 2 weeks ago
      I was allocated to bring down the warning, & I did apologise up front to both the EMA and Janet #EULAR2024. It's a tough gig regulating impactful medicines with risk-benefit, especially when our world is full of other medicines with risk-benefit trade-offs (like prednisolone). 2/ https://t.co/6YPhYHbhg8
      So how do we get from slightly increased numbers of uncommon events in a single study (ORAL Surveillance)?

      Regulators t

      David Liew drdavidliew

      3 months 2 weeks ago
      So how do we get from slightly increased numbers of uncommon events in a single study (ORAL Surveillance)? Regulators think differently to us, which partly is the difficulty of a restrictive warning. So being the Aussie I am, I asked - does it pass the 'pub test'? 4/ #EULAR2024 https://t.co/Ih9H87wH22
      Having said that, the EMA warning has elements making it extremely tough:
      - still very broad criteria that capture 80% o

      David Liew drdavidliew

      3 months 2 weeks ago
      Having said that, the EMA warning has elements making it extremely tough: - still very broad criteria that capture 80% of people who were starting JAKi - the need for "no suitable treatment alternatives" before using a JAKi, right across all diseases (not just RA) 3/ #EULAR2024 https://t.co/IsrYO7qzqM
      So I think there is plenty we could do instead.

      better regulation
      better risk stratification
      better counselling
      better

      David Liew drdavidliew

      3 months 2 weeks ago
      So I think there is plenty we could do instead. better regulation better risk stratification better counselling better risk factor management (and definitely read this if you want to be a good clinician: https://t.co/RA6ktQB7gm) 18/ #EULAR2024 https://t.co/bC5nmi8SoM
      My friend the late, great @philipcrobinson and I wrote @TheLancetRheum about what we could learn from COVID about preven

      David Liew drdavidliew

      3 months 2 weeks ago
      My friend the late, great @philipcrobinson and I wrote @TheLancetRheum about what we could learn from COVID about preventative medicine. https://t.co/55j8rduvyn It's worth us thinking how we can do better by our patients. 18/ #EULAR2024 https://t.co/zlDKYngsu0
      Here's my 'pub test' for whether the warning is appropriate. And, debate aside, I do believe that it behoves any regulat

      David Liew drdavidliew

      3 months 2 weeks ago
      Here's my 'pub test' for whether the warning is appropriate. And, debate aside, I do believe that it behoves any regulator to consider the unintended consequences of their regulation, because regulation has real consequences. 5/ #EULAR2024 https://t.co/aurbAwgl9P
      The original direct comparison study! https://t.co/hqrPKfNW1y

      Bella Mehta bella_mehta

      3 months 2 weeks ago
      The original direct comparison study! https://t.co/hqrPKfNW1y
      https://t.co/H8TijO4UUV

      Bella Mehta bella_mehta

      3 months 2 weeks ago
      https://t.co/H8TijO4UUV
      Computer vision/ image analysis is performing very well in rheumatology and can extend help to low resource settings eas

      Bella Mehta bella_mehta

      3 months 2 weeks ago
      Computer vision/ image analysis is performing very well in rheumatology and can extend help to low resource settings easily! #EULAR2024 https://t.co/8doM7foriM
      SLE RPI may be used more frequently
      and can connect the digital dots! @RheumNow https://t.co/UdVIyZJhJV

      Bella Mehta bella_mehta

      3 months 2 weeks ago
      SLE RPI may be used more frequently and can connect the digital dots! @RheumNow https://t.co/UdVIyZJhJV
      Deep learning models are detecting CPPD in radiographs pretty well!! Abst#0112 #EULAR2024 presented by @ThomasHugle ...@

      Bella Mehta bella_mehta

      3 months 2 weeks ago
      Deep learning models are detecting CPPD in radiographs pretty well!! Abst#0112 #EULAR2024 presented by @ThomasHugle ...@RheumNow https://t.co/9z3VVbyyh0
      Day 1 #EULAR2024 Do you want to learn about the effectiveness of rituximab for systemic features of #Sjogren and potenti

      Md Yuzaiful Md Yusof Yuz6Yusof

      3 months 2 weeks ago
      Day 1 #EULAR2024 Do you want to learn about the effectiveness of rituximab for systemic features of #Sjogren and potential strategies to overcome non-response? Please come to my talk today (OP0076) and say hi 👋🏼 😃 Room C7 at 1720 hr CET @RheumNow https://t.co/uo2ivC5AeY
      #EULAR2024 OP0077 Please find an interview with my dear colleague @edvital on the importance of achieving and sustaining

      Md Yuzaiful Md Yusof Yuz6Yusof

      3 months 2 weeks ago
      #EULAR2024 OP0077 Please find an interview with my dear colleague @edvital on the importance of achieving and sustaining B cell depletion for improved clinical response in #lupus #SLE @RheumNow https://t.co/4rTtFWxSvs https://t.co/4esoFTsgzC
      #EULAR2024 OP0124 EULAR recommended target oral Pred =<5mg/d. Should the threshold of LLDAS be changed to LLDAS5? Mul

      Md Yuzaiful Md Yusof Yuz6Yusof

      3 months 2 weeks ago
      #EULAR2024 OP0124 EULAR recommended target oral Pred =<5mg/d. Should the threshold of LLDAS be changed to LLDAS5? Multicentre study showed the protection gained from mortality, irreversible organ damage accrual and flare was no different btw the two targets @RheumNow #EULARBEST https://t.co/GbP25tTmX8
      #EULAR2024 OP0145 Can we reclassify people with ANA+ RMD to improve clinical outcomes & stratify for basket trials?

      Md Yuzaiful Md Yusof Yuz6Yusof

      3 months 2 weeks ago
      #EULAR2024 OP0145 Can we reclassify people with ANA+ RMD to improve clinical outcomes & stratify for basket trials? Deep machine learning identified distinct classes of ANA-RMD with distinct phenotypes & predicted long-term outcomes better than the legacy diagnoses @RheumNow https://t.co/W2hmmj0v8Y

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