#POS0114 #EULAR2022 Can we identify #lupus patients better in electronic health records? Barbero et al. used machine learning and developed a model to distinguish SLE diagnosis vs "near-misses". AUC: 0.90. Further validation can help future epidemiological studies @RheumNow https://t.co/vpLH8SWlWm

Severe heme relapses are common in #SLE pts w/prior severe heme episodes: ATTIKON SLE cohort 800 pts 👉13% w/severe heme dz: TMA, MAS, plt < 30K, hemolysis hgb < 8 👉heme issues preceded SLE dx in 1/3 of pts 👉>50% pts had severe heme flare 👉0 deaths #EULAR2022 @rheumnow POS0116

Low rates of hypersensitivity reactions (HSR) to #anifrolumab Pooled data MUSE & TULIP-1/-2 w/1100 pts: 👉1 anaphylaxis (0.15%) 👉12 HSR (3%) 👉43 infusion reaction (9%): N/V/headache 👉most easily treatable w/antihistamine, GCs, acetaminophen #EULAR2022 POS0708 @rheumnow

#POS0086PARE #EULAR2022 What #lupus symptoms/target mattered most to the patients?A survey in 342 found reduction in joint pain, rash & non-joint pain as most important. Reduced infection risk was the least. Important to be aware in assessing patients & guide studies @RheumNow https://t.co/pGXxklj1mt

#OP0002 #EULAR2022 What immune tests to monitor during pregnancy in #lupus? A meta-analysis found: 💠32% had a flare (new IS or Pred>9mg/d) 💠⬇️C3 and/or C4 in 1st Trimester predicted LN or SLE flare Worth checking C3/C4 in each trimester @RheumNow https://t.co/fPEXwReK7u https://t.co/BX6fzKzfvC

• EULAR Abstract Archive

#POS0183 #EULAR2022 Pooled analyses of 5 Belimumab RCTs showed better response vs PBO in those: 💠SLEDAI=>10 💠dsDNA+ve + ⬇️C3 and/ ⬇️C4 💠⬇️C3 and/ C4 pre-treatment 💠Response high regardless SDI, Steroid, #lupus duration @RheumNow https://t.co/fLggazbRQu

#POS0190 #EULAR2022 Disappointing news. Despite +ve Phase 2 RCT, Results from Phase 3 RCTs of Baricitinib in #lupus is inconclusive 💠SRI4 was met in BRAVE1 but not BRAVE2 despite identical study 💠BILAG MSK & Skin improved in BRAVE1 only BICLA wasn’t reported @RheumNow https://t.co/IfJRYEwFY8

#POS0186 #EULAR2022 AURORA2 (Extension of original RCT to 2 years) showed: 💠#lupus nephritis patients on voclosporin maintained meaningful low uPCR and stability of eGFR at 2yrs 💠No unexpected safety signals @RheumNow https://t.co/lnohgW7BsK