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      What is the meaning of mechanical stress-induced sacroiliac BMO MRI after childbirth in healthy women?

      5yrs follow up M

      Aurelie Najm AurelieRheumo

      1 year 3 months ago
      What is the meaning of mechanical stress-induced sacroiliac BMO MRI after childbirth in healthy women? 5yrs follow up MRI study shows: -decrease in BMO -1/3 BMO @ 5-year follow-up -15% ASAS definition of sacroiliitis -No correlation w/ symptoms @RheumNow #EULAR24 OP0222
      Understudied neurological involvement 🧠 in RA
      in pts > 65 vs. matched HC
      -larger lateral cerebral ventricles
      -brai

      Aurelie Najm AurelieRheumo

      1 year 3 months ago
      Understudied neurological involvement 🧠 in RA in pts > 65 vs. matched HC -larger lateral cerebral ventricles -brain atrophy -shrinkage of thalamus + frontal cortical regions -association w/ clinical depression @RheumNow POS0148 #EULAR2024 https://t.co/2mV4qGyBtW
      BARI reduces nociplastic pain, small cohort RA n=13
      -wk 12 ACR FM score 14 vs 10.5 p=0.03
      -fMRI data: reduction connect

      Aurelie Najm AurelieRheumo

      1 year 3 months ago
      BARI reduces nociplastic pain, small cohort RA n=13 -wk 12 ACR FM score 14 vs 10.5 p=0.03 -fMRI data: reduction connectivity between DMN and posterior insula & between IPL & anterior/middle insular regions Directs mechanims yet to be investigated @RheumNow POS0310 #EULAR2024 https://t.co/jGgvS5qqV6
      Is RA always preceded by clinically suspect arthralgia? Cohort 650+ pts CSA = 83 pts no CSA = 616 pts
      Pts w/ no CSA:

      Aurelie Najm AurelieRheumo

      1 year 3 months ago
      Is RA always preceded by clinically suspect arthralgia? Cohort 650+ pts CSA = 83 pts no CSA = 616 pts Pts w/ no CSA: -older -more frequent acute onset of symptoms -higher SJC -increased CRP -less ACPA+ No sure how accounted for memory bias #EULAR2024 @RheumNow POS1030 https://t.co/dJeN41ax5P
      9 new MOAs in SLE to review - anti-cd38, cd40, ubiquitin ligase, tyk2, toll 7/8, baff-r, blyss/april, CAR-T, glycosylate

      Peter Nash drpnash

      1 year 3 months ago
      9 new MOAs in SLE to review - anti-cd38, cd40, ubiquitin ligase, tyk2, toll 7/8, baff-r, blyss/april, CAR-T, glycosylated cd20 @rheumnow #EULAR2024
      EFFICACY AND SAFETY OUTCOMES OF TAK-279, A SELECTIVE ORAL TYROSINE KINASE 2 (TYK2) INHIBITOR, FROM A RANDOMIZED, DOUBLE-

      Peter Nash drpnash

      1 year 3 months ago
      EFFICACY AND SAFETY OUTCOMES OF TAK-279, A SELECTIVE ORAL TYROSINE KINASE 2 (TYK2) INHIBITOR, FROM A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED PHASE 2B TRIAL IN PATIENTS WITH ACTIVE PSORIATIC ARTHRITIS - smells tastes & looks like a Tyk2 - acne signal? @rheumnow #EULAR2024
      EFFECTIVENESS & COST-EFFECTIVENESS OF PATIENT-INITIATED FOLLOW-UP SUPPORTED BY ASYNCHRONOUS TELEMONITORING IN SPA (

      Peter Nash drpnash

      1 year 3 months ago
      EFFECTIVENESS & COST-EFFECTIVENESS OF PATIENT-INITIATED FOLLOW-UP SUPPORTED BY ASYNCHRONOUS TELEMONITORING IN SPA (TeleSpA-STUDY): PRAGMATIC MULTICENTRE RVT cost effective but no one will ever be examined again especially for pathology outside joints! @rheumnow #EULAR2024
      FAPI PET/CT entheseal & synovial fibroblast activation predicts PsA in high risk PsO better than MUS @RheumNow #EULA

      Peter Nash drpnash

      1 year 3 months ago
      FAPI PET/CT entheseal & synovial fibroblast activation predicts PsA in high risk PsO better than MUS @RheumNow #EULAR2024 https://t.co/uqmEvMg9WN
      more evidence in PsA - switch MOA rather than cycle within class failed first TNF @RheumNow #EULAR2024 https://t.co/hf2U

      Peter Nash drpnash

      1 year 3 months ago
      more evidence in PsA - switch MOA rather than cycle within class failed first TNF @RheumNow #EULAR2024 https://t.co/hf2UB5MXEy
      opposing point of view especially in males at 3 years !@RheumNow #EULAR2024 https://t.co/CXxIScQbFD

      Peter Nash drpnash

      1 year 3 months ago
      opposing point of view especially in males at 3 years !@RheumNow #EULAR2024 https://t.co/CXxIScQbFD
      computer screen safety
      Impact of regulatory warning on JAK inhibitors
      1 year 3 months ago
      The development of JAK inhibitors represents an advance for the treatment of inflammatory rheumatic diseases. However, the enthusiasm in using this target has waned since the publication of the ORAL surveillance clinical trial in 2022. Subsequently, both the FDA and EMA issued a warning on using JAKi in patients with certain risk factors, e.g., ≥65 years, at increased risk of MACE, current smoker or past smoker and at increased risk of cancer,
      #wasup in #GCA?

      #upadacitinib +RCT in #temporal #arteritis LBA0001

      Residual #inflammation in 1/3 of pts at 6 mo #Rx w

      Janet Pope Janetbirdope

      1 year 3 months ago
      #wasup in #GCA? #upadacitinib +RCT in #temporal #arteritis LBA0001 Residual #inflammation in 1/3 of pts at 6 mo #Rx w #TCZ on repeat TA Bx OP0621 #PMR cases #Leflunomide beats #MTX for #pred sparing ⬇️relapses But MTX dose was low POS0280 #EULAR2024 @RheumNow @eular_org
      New #JAKi #disease #results

      #Baricitinib in #alopecia #areata esp 4mg/d

      #Upadacitinib in Crohn’s

      #Upa in #polyartic

      Janet Pope Janetbirdope

      1 year 3 months ago
      New #JAKi #disease #results #Baricitinib in #alopecia #areata esp 4mg/d #Upadacitinib in Crohn’s #Upa in #polyarticular #JIA & kid #PsA +RCT of UPA in #GCA Awaiting results of #SLE With #deucravicitinib & UPA #RCTs #EULAR2024 @eular_org @RheumNow
      #Behcet’s #syndrome is increasing in the UK

      ? ⬆️ Detection

      ? Changing population demographics

      ? Other reasons

      Janet Pope Janetbirdope

      1 year 3 months ago
      #Behcet’s #syndrome is increasing in the UK ? ⬆️ Detection ? Changing population demographics ? Other reasons Poster discussion POS0258 #EULAR2024 @RheumNow @eular_org @Pr1yankaC https://t.co/SEzmJnFMhM
      When would I use
      #Aclasta vs #Prolia since #denosumab has LESS #fractures

      ▶️younger women with #osteoporosis requ

      Janet Pope Janetbirdope

      1 year 3 months ago
      When would I use #Aclasta vs #Prolia since #denosumab has LESS #fractures ▶️younger women with #osteoporosis requiring Rx due to long safety ▶️less wearing off when stopping it ▶️noncompliant Pts as prolia reverses effect when dose is missed @RheumNow #EULAR2024 @eular_org https://t.co/0RTGx0sCTd

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