✅ Michelle Petri in the VERY FULL #ACR23 early session about #lupus: BEFORE stepping-up with biologics, ask the key questions: -Are you using proton-pump inhibitors (Drug-induced SCLE) -Can I see your sunscreen? -Can I see your hat? -Are you smoking? -Any HCQ blood levels? https://t.co/s73FqyjLOn

Conundrum of #Clinically #Quiescent #Serologically #Active #SLE-half flare within 5 yrs; can have organ damage. Large cohort-China 20% met def’n- diff trajectories 37% flare 1/6 got damage in f/u Some tapered Rx How to identify safe to d/c Rx? 2555 #ACR23 @ACRheum @RheumNow https://t.co/f49BQspQsz

#Lupus #nephritis - #inflammatory #fibrosis predicts #renal damage on #kidney #bx @ACRheum @RheumNow #ACR23 #2552 - similar in CRF from #Diabetes etc Biomarker is i-IFTA - same as other CRF diseases https://t.co/2LNn5Wn7rJ

What % of pts in #RCTs in #SLE go in to #LLDAS - Pooling 5 RCTs - starting on #belimumab vs #placebo? More w #bDMARD @RheumNow @ACRheum #ACR23 abst#2551. True w DORIS - #lupus #rem but overall lower rates in each group https://t.co/VPZrYCVjof

After attaining #remission or #LLDAS after a flare - HALF flare over f/u esp if tapering pred to <7.5 or 5 mg. #HCQ was protective. 65% got LLDAs and 45% rem in 1/2 yr - longer time to get #remission #2553 #ACR23 @RheumNow @ACRheum #ACRbest Asian cohort of #SLE largest@in world https://t.co/yBBqYJZVOe

Wouldn’t it be great to assess immune changes in #SLE before #clinical #lupus #flare? Without over treatment too! YOU CAN Lupus flare risk index calculated prior to disease activity change or stable pt. Results combined for score 11 mediators #ACR23 @RheumNow @ACRheum abst#2554 https://t.co/gUimJLrJ33

The Lupus APOL1 Story Dr. Kathryn Dao talks with Dr. Ashira Blazer, Rheumatology Research Foundation Dubois Memorial Lecturer on APOL1 High Risk Genotype in SLE: A Genes in Context Story, at the 2023 ACR Convergence meeting in San Diego, CA. #ACR23 https://t.co/VXxJxk0kbS https://t.co/1n1COXcYA4

• The Lupus APOL1 Story | RheumNow