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Rheumatoid Arthritis

      Rheumatology Roundup
      Drs. Jack Cush and Arthur Kavanaugh discuss highlights and key takeaways from ACR 23.
      While there wasn’t much original new programming and research presented on the final day, that didn’t slow the RheumNow faculty from tweeting the noteworthy “Best of ACR” abstracts. Enjoy these below.
      The last day at ACR23 was a ghost town as most left, largely because there was limited programming on the fourth and final day. The main attraction on Day 4 was the late-breaking abstract – oral presentations.  Here’s a list of the late breakers; below, I provide commentary on the ones that caught my attention.
      Daily Recap - WEDNESDAY
      How do we manage difficult discussions about pregnancy in RA?

      Most rheums know that it is important to get pregnancy p

      Dr. John Cush RheumNow

      1 year 7 months ago
      How do we manage difficult discussions about pregnancy in RA? Most rheums know that it is important to get pregnancy planning right for women of childbearing age living with rheumatic diseases. That is easier said than done, though... https://t.co/cXtqqVv6fp https://t.co/k5afTUKYf8
      L20 at #ACR23

      Phase 3 RCT of #Telitacicept vs. placebo in #RA
      ☝🏻B-cell neutralization by targeting BlyS and APRIL

      ARD & RMD Open ARD_BMJ

      1 year 7 months ago
      L20 at #ACR23 Phase 3 RCT of #Telitacicept vs. placebo in #RA ☝🏻B-cell neutralization by targeting BlyS and APRIL ✅ better ACR20 and 50 response at W24 ✅ favorable structural response ✅ good safety profile ❓ few seronegative patients A new small molecule to treat #RA? PAJ https://t.co/fyrqAya41e
      #ACR23 #EdLovering presenting on association b/w #RA, #CVD & #Dementia:
      👉🏻CVD is not a signif mediator b/w RA

      Elena MyasoedovaMD ☀️

      1 year 7 months ago
      #ACR23 #EdLovering presenting on association b/w #RA, #CVD & #Dementia: 👉🏻CVD is not a signif mediator b/w RA &Dementia 👉🏻 signif synergy b/w RA & CVD on dementia (HR 2.45 vs those w/o RA&CVD) 👉🏻 ⬆️ risk of dementia in RA mostly in people with RA+CVD #Mayoclinicrheumatology https://t.co/5kqs3HAACn
      Impressive and important study supporting safety of TNF inhibitors among patients with RA-ILD. Elegant methods of target

      Jeffrey Sparks MD MMSc jeffsparks

      1 year 7 months ago
      Impressive and important study supporting safety of TNF inhibitors among patients with RA-ILD. Elegant methods of target trial emulation. Congrats to the authors on plenary presentation! #ACR23 https://t.co/P7keAoOX7M
      Nipocalimab (say it a couple of times) is a FcRn (neonatal Fc receptor) inhibitor. In short promotes degradation of IgG

      Tue Kragstrup KragstrupTW

      1 year 7 months ago
      Nipocalimab (say it a couple of times) is a FcRn (neonatal Fc receptor) inhibitor. In short promotes degradation of IgG incl autoantibodies (and investigated in myasthenia). Prof Taylor presents that it might work in CCP high titer RA at #ACR23. #ACRambassador @ACRheum https://t.co/DqlsOv7AVI
      B cell signalling reduction to treat #RA?
      Telitacicept RCT showed #efficacy in active RA w MTX -maybe blunted high respo

      Janet Pope

      1 year 7 months ago
      B cell signalling reduction to treat #RA? Telitacicept RCT showed #efficacy in active RA w MTX -maybe blunted high responses but no active comparator, only #PBO so difficult to compare to current Rx and only from 1 country China. Past bDMARDs not reported L20 @RheumNow @ACRheum
      As per #ACR23 ABST0433, what % of RA patients on US Medicare are on a DMARD within 1y of diagnosis?

      I'm not talking you

      David Liew drdavidliew

      1 year 7 months ago
      As per #ACR23 ABST0433, what % of RA patients on US Medicare are on a DMARD within 1y of diagnosis? I'm not talking your choice of b/tsDMARD. I'm talking any cs/b/tsDMARD of any sort. Hear from @JihaRheum to skip to the answer: https://t.co/lI2M20JWKC Truly stunning. @RheumNow
      Taylor et al. Novel blood assay for sero+ and sero- RA. Differentiates well from other diseases. May be very valuable fo

      Richard Conway

      1 year 7 months ago
      Taylor et al. Novel blood assay for sero+ and sero- RA. Differentiates well from other diseases. May be very valuable for sero- RA diagnosis = sensitivity 83.7%, +LR 21.46, and -LR 0.17. Needs validation. Abstr#2586 #ACR23 @RheumNow https://t.co/jw41F8YohE https://t.co/kXi3km0b07
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