Gout
The last day at ACR23 was a ghost town as most left, largely because there was limited programming on the fourth and final day. The main attraction on Day 4 was the late-breaking abstract – oral…
10 months 3 weeks ago
AR882 a novel and selective URAT1 inhibitor is a safe, efficacious sUA lowering, tophus resolution and with a 68% decrease in total urate crystal volume of the feet and ankles after AR882 75 mg once daily for 6 months. Keenan R, Abst#L15 #ACR23 @RheumNow https://t.co/gMCcSI1v9W https://t.co/lk3XQCaw0A
10 months 3 weeks ago
In case you missed it!
AR882-selective oral URAT1i added to #allopurinol rapidly improves/dissolve #tophi. Given with #colchicine,
#placebo 3/4 flared vs <1/2 w drug.
My critique is why not optimize allopurinol dose - only 300 mg, no fuboxastat
L15 #ACR23 @RheumNow @ACRheum https://t.co/NZWLpWXT51
10 months 3 weeks ago
US adults with #gout had higher 10-year all-cause mortality rates than those without
Premature mortality in gout
➡️Has not improved over time despite improved survival in the general population
➡️Worse among women
➡️Worse among Black individuals
#ACR23
👉🏽https://t.co/NDCIhKfCNL https://t.co/uKCswHKU0n
10 months 3 weeks ago
Who uses #cannabis in #rheumatic #diseases? Those who smoke, have higher pain, more anxiety, poor sleep are more likely to have used cannabis for their rheumatic disease. Half of the >2900 respondents have tried #cannabis. Use of #biologics reduced use. #980 @RheumNow @ACRheum https://t.co/DQDRQN40zR
10 months 3 weeks ago
McCormick et al. No improvement in premature mortality gap in gout over time. 19% increased mortality in gout. Independent of serum urate and CV risk factors. Abstr#2428 #ACR23 @RheumNow https://t.co/lSoEvajN3O https://t.co/uWNokm7LCT
10 months 3 weeks ago
Gout mortality
A#2428 #ACR23 @RheumNow
1988-1994 (early) v 2007-2016 (late): Has not improved over time
Independent of serum uric acid
Female gout: increased mortality
Black gout pts also increased
Conclusion: the inflammation, not the uric acid is the risk https://t.co/LTFoSFzaBu
10 months 3 weeks ago
#ACR23
#SGLT2 inhibitors assoc with
⬇️ urate
⬇️ flares if #gout
⬇️mortality
impact on #metabolicSyndrome ✅ https://t.co/ZIqDqirqar