Lupus

Dr. John Cush RheumNow
1 year 7 months ago
Urinary biomarkers precede loss of kidney function for lupus nephritis
In Abstract 0850, Dr. Andrea Fava from Johns Hopkins presents research on the value of urinary biomarkers as measure of intrarenal inflammation.
https://t.co/MJb9F3uEgr https://t.co/oXvNLelE89


Dr. John Cush RheumNow
1 year 7 months ago
Less (Glucocorticoids) is More in Lupus Nephritis
Dr. Yuz Yusof talks with Dr. Amir Saxena about abstract 0781 at the 2023 ACR Convergence meeting in San Diego, CA.
https://t.co/EriaJvBPj9 https://t.co/x5hNIAgBz2

Drs. Jack Cush and Arthur Kavanaugh discuss highlights and key takeaways from ACR 23.
While there wasn’t much original new programming and research presented on the final day, that didn’t slow the RheumNow faculty from tweeting the noteworthy “Best of ACR” abstracts. Enjoy these below.
Since chronic kidney disease is one of the strongest CV risk factors, any new strategy to reduce proteinuria and avoid a decline in renal function may likely improve patient outcomes. In large cardiovascular outcome trials, the use of a fairly new-kid-on-the-block therapy, sodium–glucose cotransporter-2 inhibitors (SGLT2i) appear to be both cardio and renal-protective. Would the use of SGLT2i have the same impact in SLE?
The last day at ACR23 was a ghost town as most left, largely because there was limited programming on the fourth and final day. The main attraction on Day 4 was the late-breaking abstract – oral presentations. Here’s a list of the late breakers; below, I provide commentary on the ones that caught my attention.

Janet Pope
1 year 7 months ago
#Yr in #Preview #ACR2023 J Buyon
Pregnancies in #SLE have high #VTE risk - look at Ob/Gyn guidelines for prophylaxis of LMW #heparin - all SLE pregnancies recommend #ASA & #HCQ
biomarkers for #renal #lupus, #HCQ levels ?aid #Rx
-#SLE nephritis low prednisone
2 IS>1
@RheumNow

Janet Pope
1 year 7 months ago
#Hope for people with #SLE
Insights from #ACR23
#Lupus #nephritis - half the oral #prednisone is = to 1 mg/kg induction after IV #solumedrol LESS PRED
#Anifrolimumab reduces similarly skin, jts, other common organs in #SLE RCTS APPROX 2X improvement vs PBO
@RheumNow @ACRheum https://t.co/OtdfTxZxr4


sheila
1 year 7 months ago
Frail pts with SLE is associated with 🔸prolonged hospitalizations (28.89%), 🔸significantly higher in-pt mortality (2.88%)
🔸fewer days-to-readmission (59.8%)
vs. non-frail pts with SLE
(CLeung et al)
Screen your SLE pts for frailty too.
#ACR23 ABST2590 @RheumNow https://t.co/c4YP5h2ypn

Should rheumatologists be counseling patients on cervical cancer prevention and screening? The data from Abstract #1479 at ACR Convergence 2023 suggests that this should be an important conversation with our female lupus patients.

Md Yuzaiful Md Yusof
1 year 7 months ago
#ACR23 Abstr#2587 Can we agree on how to measure frailty in #SLE? A cohort study: moderate agreement at best among SLICC-FI, SPPB, FRAIL=>2 & PROMIS PF=<40. SLICC-FI was robust predictor of all outcomes except for cognitive impairment. FRAIL & PROMIS not far behind @RheumNow https://t.co/qWjM4crPvg


Dr. John Cush RheumNow
1 year 7 months ago
The Heart of Lupus
During ACR 2023 Convergence, several abstracts were presented evaluating the prevalence of CV disease and exploring new tools to predict CV disease. The ones that caught my eye included...
https://t.co/5Qk2fF3nlA #ACR23 https://t.co/Rja7K44BUf


sheila
1 year 7 months ago
COVAD2 data:
⬆️proportion of SLE pts from lmHDI countries were on CS(73% vs 59% p=0.0002), antimalarials(81% vs 68% p=0.0002) & IS(66% vs 53%p=0.0009) vs pts from hvhHDI countries
Comorbids more in younger pts from lmHDI (prob from CS use)
#ACR23 ABST2269 @RheumNow @rheumarhyme https://t.co/4CLGFYG1d0
