Lisa 🐳🗺🧭 rheumarhyme
1 year ago
One for you, one for me!
So many pasalubong char
@RHEUMarampa
@RheumNow
#acr23 #ACRambassador https://t.co/v0mZ9vbadx
Aurelie Najm
1 year ago
Cellular based biology explanation of sex bias in ARDs 👀
Data from AMP w/ sc-RNA seq from synovial tissue shows:
Enriched inflammatory pathways in females synovial macrophages clusters vs. males
Basis for gender specific treatment strategies?
@RheumNow ABST0724 #ACR23 https://t.co/1p8PDIRNoI
Robert B Chao, MD
1 year ago
Is there a difference in secukinumab vs. adalimumab biosimilar on radiographic progression in a subgroup of axSpA pts with syndesmophytes or CRP levels?
Radiographic progression equally low in both drugs
NO difference in syndesmophytes or CRP
@RheumNow #ACR23 Abs#0522 https://t.co/1TBKAxuKPE
sheila
1 year ago
In their study, Dr Deng et al identified TRAF5 as susceptible gene for SLE-PAH
✳️TRAF5 deficiency activates BMP/TGFB signaling w/⬆️PAEC apoptosis
✳️TRAF5 overexpression attenuated PAH sxs in mice
TRAF5 as potential BM for dx/novel tx target in SLE-PAH?
#ACR23 ABST0723 @RheumNow https://t.co/WT9vQo8y8s
Mike Putman EBRheum
1 year ago
Important plenary re:reduced vs standard GC for AAV... IRL
PEXIVAS & recent guidelines supported low dose taper
Real world data w/severe dx? Increased risk of death & ESKD for REDUCED pts
Need full data but yikes...
@RheumNow #ACR23 #ACRBest https://t.co/3S23O9d1ok
Eric Dein
1 year ago
Abst#0725 #ACR23 @RheumNow
PEXIVAS Real life data!
GPA & MPA pts - Retrosp observ study
⭐️Reduced-dose GC regimen ass w/ INCREASED risk of death, ESKD, progression
Greatest risk: pt w Cr levels >300 umol/L, RTX induction Rx
⚠️Caution w/ reduced GC, RTX, severe kidney dis
#ACRBest https://t.co/7qI5c1ZiqO
TheDaoIndex KDAO2011
1 year ago
Look who I interviewed for @RheumNow!!@ashira_md shares the story of APOL1 effects on SLE . Patients with the variants have more aggressive renal and vascular disease. #DuboisLecture #ACR23 #StrongWomen #FutureNobelRecipient https://t.co/IzRsHwaMIb
Robert B Chao, MD
1 year ago
Interesting study on PEXIVAS reduced steroid use from today's plenary session!
Reduced steroid dose in GPA/MPA pts associated w/
INCREASED risk of death, ESKD, progression of dz
Even greater risk in pts with higher Cr lvls or RTX induction use
@RheumNow #ACR23 Abs#0725 #ACRbest https://t.co/frsOrANKhf
sheila
1 year ago
In this real world EHR-based SLE cohort, AJorge: BEL was assoc w/⬇️risk of damage prog vs. MMF (HR 0.74 [95% CI 0.67-0.83) but no diff bet BEL vs. MTX/AZA at 3yrs
Further prospective studies req'd?
BEL remains an option for non-renal SLE tx.
#ACR23 ABST0606 @RheumNow https://t.co/KabBeXKpvk
TheDaoIndex KDAO2011
1 year ago
Did you know?
👉APOL1 variants are protective against trypanosomiasis.
👉Despite reassuring renal biopsies, SLE pts with #APOL1 variants had:
⬆️progression to ESRD, ⬆️atherosclerosis, ⬆️osteonecrosis (likely related to endothel dysfnx) #ACR23 @ashira_md @RheumNow #DuboisLecture https://t.co/w1lnGMPFAQ
Eric Dein
1 year ago
Abs#0726 #ACR23 @RheumNow
MSUS recs in Canadian Rheum training 🇨🇦:
Focus MSUS exam of hands/wrists/feet: ID effusion, synov, erosions v osteophyte, tenosyn
Limited MSUS of knee/ankle for effusion
@USSONAR_Rh @MymaAlbaydaMD
Agree: MSUS should be part of rheum training for all https://t.co/UNPpAA1p0V
Richard Conway
1 year ago
Real world data on low dose PEXIVAS steroid by Nagle et al. Increased risk of progression/relapse/death/ESKD in those with severe GPA/MPA HR 1.72. More marked in those with creat>300 or with RTX induction Abstr#0725 #ACR23 @RheumNow https://t.co/vTXVZfjbXx https://t.co/4FuMjxOuyB
Janet Pope
1 year ago
Should there be a minimum ultrasound training as competencies in rheumatology training? Abst0726 #ACR23 @ACRheum @RheumNow #RheumEd #POCUS https://t.co/mqdcPEeMYW
Richard Conway
1 year ago
INVIGORATE-2 RCT of IV secukinumab in PsA. Demonstrates efficacy as expected. My big question is why are we doing trials like this against placebo? Surely a non-inferiority vs s/c secukinumab is more ethical. Abstr#0776 #ACR23 @RheumNow https://t.co/Usw0iwZEF5 https://t.co/DP6Gb4pF8a
Janet Pope
1 year ago
Do you think point of care #ultrasound should be mandatory in #rheumatologu #residency #training? @RheumNow @ACRheum #ACR23