@RheumNow #acr20 abs0063 in silico, in vitro &clinical study: Amitriptyline, naloxone& thalidomide prevent NOS2, IL6, IL1B, MMP9 release, inhibits NLRP3 inflammasome pathway> decreased colchicine consumption in gout pts using above meds for other indications #acrbest #different https://t.co/cz3htmtBU0

#ACR20 keynote Infectious disease Dr Eric Rubin @NEJM EIC answers questions about medications, immunity and vaccines in #COVID19. Many post covid inflammatory symptoms but not sure if its because of background autoimmunity. Need more data. More to come in a few months @RheumNow

Eric Rubin, MD, editor-in-chief @NEJM: "All of the vaccines are based on the same hypothesis". Scary thought in relying in one solution #ACR20. @RheumNow

Lots of JAK safety studies in #ACR20. Abst#0237 pooled 5 RCTs on UPA. Good safety numbers and low VTE rates, but watch out for herpes zoster trend, elevated in UPA (30>15mg) compared to MTX and ADA. @RheumNow

Determining safety of a vaccine requires NUMBERS (more subjects to detect rare, serious side effects) and TIME (longer trials to be able to detect more delayed side effects) per Dr. Eric Rubin’s (ID physician’s) keynote address at #ACR20 @RheumNow

“When we will have a vaccine. The answer is not so simple. Safety [of vaccines] is an important component of making a decision to move forward.”- Dr. Eric Rubin at #ACR20. We want a vaccine that is both SAFE and EFFECTIVE! @RheumNow

Dr. L Calabrese excellent review of irAEs and a proposed personalized algorithm for mgmt of irAE #ACR20 @LCalabreseDO @rheumnow He believes there should be more studies combining TNFi or IL-6 with CPI https://t.co/GbvgXtNJnI

Dr. Noha Abdel-wahab on timing for grade 3/4 irAE fastest with the skin after exposure to CPI #ACR20 @rheumnow https://t.co/sc5c6Zn3Uq

“Immunology is the cornerstone of medicine and we are the experts.” #ACR20 president, Dr. Ellen Gravallese @RheumNow

JAKs are no longer new, Winthrop et al presents 8.4 year BARI data in Abst#0202 at #ACR20. VTE risk stable over time, again shows reason to vaccinate patients for zoster before starting. @RheumNow https://t.co/OSIvHl2f7Y

How would you change csDMARDS and bDMARDS a few days before vaccination - if/when #COVID19 KILLED vaccine comes in (Assuming live vaccine would need strict medication management.) #ACR20 @RheumNow

Vaccinate your pts against pneumococcal- it works! 595 vaccinated pts with RA & SpA vs 2379 nonvaccinated followed to 10 yrs showed 50% less pneumonia if vaccinated even though those pts had more infections prior. Limitation not RCT & not vaccine I use @RheumNow @CRASCRRheum https://t.co/SySEL19Gcn

Delighted to be reporting for @RheumNow at #ACR20! Here, I review the last year in #infection in #rheumaticdiseases (it’s been a busy one!) and highlight just a few of the abstracts on infections (incl #COVID19), #vaccination and #immunogenicity. Enjoy! https://t.co/x1pzyOICAF

• Infection and Rheumatic Diseases: A New Dawn | RheumNow