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Psoriatic arthritis

      Year in Review: Dr. P Seo

      Novel PsA therapy on the horizon:

      ⭐️Bimekizumab
      ➡️ Anti-IL17A, ANti-IL17F ab

      🚩BE

      Meral K. El Ramahi, MD MeralElRamahiMD

      1 year 10 months ago
      Year in Review: Dr. P Seo Novel PsA therapy on the horizon: ⭐️Bimekizumab ➡️ Anti-IL17A, ANti-IL17F ab 🚩BE COMPLETE ➡️ TNFi failures ➡️Phase III, 400 pts, bimekizumab, PBO ➡️ Wk 16: improvements in joint and skin #ACR23 @RheumNow
      Year in Review: Dr. P Seo

      Novel PsA therapy on the horizon:
      ⭐️Bimekizumab
      ➡️ Anti-IL17A, ANti-IL17F ab

      🚩BE

      Meral K. El Ramahi, MD MeralElRamahiMD

      1 year 10 months ago
      Year in Review: Dr. P Seo Novel PsA therapy on the horizon: ⭐️Bimekizumab ➡️ Anti-IL17A, ANti-IL17F ab 🚩BE OPTIMAL ➡️ tx-naive ➡️Phase III, 852 pts, bimekizumab, PBO, ADA ➡️ Wk 16: same as ADA for joints, BETTER FOR SKIN #ACR23 @RheumNow
      Year in Review: Dr. P Seo

      Novel PsA therapy on the horizon:

      ⭐️Brepocitinib
      ➡️ Tyk-2 inhibitor: IL12/23 & t

      Meral K. El Ramahi, MD MeralElRamahiMD

      1 year 10 months ago
      Year in Review: Dr. P Seo Novel PsA therapy on the horizon: ⭐️Brepocitinib ➡️ Tyk-2 inhibitor: IL12/23 & type I IFN ➡️ Phase Ib, 218 pts, 8% TNFi failure ➡️ 71% on concurrent MTX ➡️ Wk 16: ACR 50/70 & PASI75/90 improved, maintained through week 52 #ACR23 @RheumNow
      Love teaching about the PsA-AxSpa-IBD venn diagram of disease manifestations

      Interesting idea, using fecal calprotectin

      Mike Putman EBRheum

      1 year 10 months ago
      Love teaching about the PsA-AxSpa-IBD venn diagram of disease manifestations Interesting idea, using fecal calprotectin to trigger colonoscopy in pts w/PsA/axSpA ~40% w/pathologic finding, 4.4% dx w/IBD Jives w/my clinical experience @RheumNow #ACR23 Abstr0495 #ACRBest https://t.co/rIQpJnup9v
      Kudos @AlexisOgdie & co for their work in this area

      Given proliferation of database research for causal inference,

      Mike Putman EBRheum

      1 year 10 months ago
      Kudos @AlexisOgdie & co for their work in this area Given proliferation of database research for causal inference, super important to have validated criteria to identify diseases Many spaces (looking at you sarcoidosis) where this is almost entirely absent @RheumNow #ACR23 https://t.co/krkgWAhjMr
      I’m not TYK’ed! Another TYK2 #TAK-279 in #PsA RCT. Yup it works in ballpark of other PsA #Rx. #PASI75 45.7%. No obvi

      Janet Pope

      1 year 10 months ago
      I’m not TYK’ed! Another TYK2 #TAK-279 in #PsA RCT. Yup it works in ballpark of other PsA #Rx. #PASI75 45.7%. No obvious dose response w 15 and 30 mg daily but more #acne at higher dose. #ACR23 @ACRheum @RheumNow poster L12 Where to use vs #Deucravitinib? Too early to say as Ph2 https://t.co/nMkgOlUf6s
      Interesting question... but feels like some time related bias or perhaps confounding?

      Seems implausible that MTX &

      Mike Putman EBRheum

      1 year 10 months ago
      Interesting question... but feels like some time related bias or perhaps confounding? Seems implausible that MTX & biologic would be protective for PsO & harmful for PsA @RheumNow #ACR23 Abstr 0498 https://t.co/pSRoLHRTAm
      Of the many exciting advancements for patients with psoriatic arthritis at ACR Convergence, one upcoming therapy stood out: the dual IL-17A/F inhibitor bimekizumab. Nearly two dozen bimekizumab abstracts will be featured at this year’s meeting and it recently received authorization in Europe and the U.S. for psoriasis. That makes this the year I plan to figure out where this drug will be useful for my patients with PsA. 
      In clinical practice, pulmonary manifestations of rheumatic medical diseases such as rheumatoid arthritis (RA), psoriatic arthritis (PsA), and peripheral spondyloarthritis (pSpA) are typically not screened for upon diagnosis of a rheumatic disease in patients without any signs or symptoms suggestive of pulmonary involvement.
      Join us tonight at 6pm PT/ 9pm ET for our daily #ACR23 recap. https://t.co/0RDwTdzhwS

      Dr. John Cush RheumNow

      1 year 10 months ago
      Join us tonight at 6pm PT/ 9pm ET for our daily #ACR23 recap. https://t.co/0RDwTdzhwS
      #ACR23 Abs #0505 found use of IL-17 inhibitors and oral DMARD alone were associated with a decreased likelihood of achie

      Dr. Rachel Tate

      1 year 10 months ago
      #ACR23 Abs #0505 found use of IL-17 inhibitors and oral DMARD alone were associated with a decreased likelihood of achieving MDA in PsA. Small sample size, but interesting finding nonetheless. https://t.co/CAZGykwxRT @rheumnow https://t.co/8ptF8aTIFu
      How can we maximise digital health to improve outcomes. Come and visit my poster session today and it will be good to me

      Dr. Antoni Chan

      1 year 10 months ago
      How can we maximise digital health to improve outcomes. Come and visit my poster session today and it will be good to meet IRL. I’m presenting poster #0507 using digital e-PROMs to measure disease activity in psoriatic arthritis #digital Abst #0507 #ACR23 @RheumNow https://t.co/R9LX8H9X0E
      #ACR23 Abs 0484 found higher hs-CRP levels helped identify PsO pts at high risk of future development of PsA. Unclear ti

      Dr. Rachel Tate

      1 year 10 months ago
      #ACR23 Abs 0484 found higher hs-CRP levels helped identify PsO pts at high risk of future development of PsA. Unclear timeline, but this may help to early ID referrals to rheum. https://t.co/4JRsI6iEgI @rheumnow https://t.co/sXNwyL87Ud
      Pain, itch, and fatigue associated with decreased work productivity/impairment in PsA and PsO pts. #ACR23 considerations

      Dr. Rachel Tate

      1 year 10 months ago
      Pain, itch, and fatigue associated with decreased work productivity/impairment in PsA and PsO pts. #ACR23 considerations for treatment for these pts should include these factors. Abs #0488 https://t.co/mLG5ohFopQ @rheumnow https://t.co/8ANL4pcxM2
      Different plant products
      We need more RCTs
      Cohort studies have a lot of attrition
      Survey data shows increased utilizati

      Bella Mehta bella_mehta

      1 year 10 months ago
      Different plant products We need more RCTs Cohort studies have a lot of attrition Survey data shows increased utilization #ACR23 @RheumNow https://t.co/H2pOEJ99Qh
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