Baker et al. Danish registry study. Truncal vagotomy increases risk RA (but not OA), HR 2.62 (95% CI 1.47-4.67). Support for vagus nerve stimulation in RA? Abstr#0836 #ACR23 @RheumNow https://t.co/SbphSMLHc7 https://t.co/93SfyGizLt

Inflammatory reflex suggests role of vagal nerve in inflammation regulation Danish database Truncal vagotomy 2000+ pts matched w/ 22000+ = Increase risk for RA HR 2.6 Not the case for supras elective vagotomy (HR 1) No influence on OA @RheumNow #ACR23 ABST0836 https://t.co/3ThYP1nKTe

Here's the counterpoint to the previous positive tweet on vagal nerve stimulation in RA. The previously promising data on auricular vagus stimulation falls flat on further study Abstr#0837 #ACR23 @RheumNow https://t.co/APnrPhWA9q https://t.co/adA0H1VETt

This is particularly interesting considering this 👇🏼👇🏼 First RCT of NI auricular vagal nerve stimulation did not meaningfully improve RA disease activity or outcomes. No SAEs Is this supporting the need for other VNS modalities? @RheumNow #ACR23 ABST0837 https://t.co/yFcMPoSc31 https://t.co/G069XwUyAz

What is D2T PsA? A proposal of definition in ABST0777 Thoughts: A lot of features are extrapolated from the EULAR RA definition RA & PsA population are hardly comparable Lack of emphasis more problematic domains ie. dactylitis Further work is required @RheumNow #ACR23 https://t.co/A28e6XBME3

Fascinating how upadacitinib may well have an effect on pain in RA, beyond inflammation. Now seen similar for bari in RA & guselkumab in PsA. And, if real, for some people could be a massive get. Love to see dedicated studies SELECT-COMPARE post-hoc #ACR23 ABST0429 @RheumNow https://t.co/Tk278mGJYY

Klein et al. 205 RA-ILD. MUC5B not significantly associated survival, although wide CIs, aHR 0.75 (0.45, 1.24). Abstr#0772 #ACR23 @RheumNow https://t.co/ZfIIr2BbbR https://t.co/47DPYWNpL9

FAPα possible therapeutic biomarker target of pathogenic fibroblasts. #ACR23 Abs 0802 demonstrates potential therapeutic efficacy of fibroblast-targeted immunotherapy as a novel treatment in inflammatory disease. https://t.co/ZGUfC6PZxa @rheumnow https://t.co/jj9BeuvTuc

Plasma MMPs and RA-ILD. Strong association MMPs 7 & 9 with prevalent RA-ILD. Abstr#0770 #ACR23 @RheumNow https://t.co/5qWeK3lAly https://t.co/SyZY2OhcbH

Always great to see UCSD represent at #ACR23! Pregnant women with rheumatic diseases and antiphospholipid syndrome higher a HIGHER risk for acute cardiovascular events 30% of events occurred postpartum @RheumNow Abs#0722 https://t.co/CqZedfOlBC

Are anti CCP3 the new anti CCP2 antibodies? Not yet! Anti-CCP3 associated w/ diagnosis of RA in a population of patients w/ MSK symptoms But… very strong overlap between CCP2 and 3 with only 3.4% positive for CCP3 negative for CCP2 @RheumNow #ACR23 ABST 0389 https://t.co/BHRqCbqEYw

Detectable hs-cTnT at baseline was associated with future MACE HR 5.6, in the hsCRP high→low cohort with high inflammation at baseline, not vice versa. hs-cTnT may provide additional info for assessing CV risk, Weber et al, Abst#0387 https://t.co/M4zyz2tzIO #ACR23 @RheumNow https://t.co/omMgpRzBA5

Non invasive screening for pulmonary involvement in early RA Combination of PFT and Lung 🫁 US: -50% with interstitial or focal changes or pleural effusion on US -58% with abnormal DLCO Correlation w/ higher disease activity. Pathological meaning? @RheumNow ABST 0393 #ACR23 https://t.co/BBcOEgcJK2