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Rheumatoid Arthritis

      Retrospective study(2016-2019) of referred newly, suspected (#RA) pts found no value in initial Xrays. Only 32/724 patie

      Dr. John Cush RheumNow

      1 year 11 months ago
      Retrospective study(2016-2019) of referred newly, suspected (#RA) pts found no value in initial Xrays. Only 32/724 patients (4.4%) had RA like erosions, with Erosions leading to a Dx in only 2 pts (0.3%) & changed prognostic classification in 3 pts (0.4%) https://t.co/fi48WiBgIc https://t.co/skObArXYr6
      Research work from the Accelerating Medicines Partnership (AMP: RA/SLE) Network, was published in Nature and more specifically characterizes RA synovium into several cell-type abundance phenotypes (CTAPs). Could CTAPs known disease features or more effective future therapies? 
      A recent CDC reports estimates that in 2019–2021, 21% of U.S. adults (53.2 million) have physician diagnosed arthritis. Now, an updated report shows a larger number (~33%) of U.S. veterans having diagnosed arthritis. Compared to nonveterans, this prevalence was double in men, and 60% higher in women.
      Patients Don't Read Textbooks

      RA patient unresponsive to biologics, now has enthesitis; what to do?

      QD Clinics are sp

      Dr. John Cush RheumNow

      1 year 11 months ago
      Patients Don't Read Textbooks RA patient unresponsive to biologics, now has enthesitis; what to do? QD Clinics are sponsored by RheumNows Coverage of #ACR23 live from San Diego https://t.co/hlacYXm0Nh https://t.co/52Xy3E8kXi
      The American College of Rheumatology's (ACR) has published a preview of new research from ACR Convergence 2023 showing that AI and a deep learning system could accurately identify and predict joint space narrowing and erosions in hand radiographs of patients with rheumatoid arthritis (RA).
      Routine hand and foot radiographs in more than 700 patients being evaluated for rheumatoid arthritis (RA) made almost no difference in diagnosing the condition nor in predicting its course, Dutch researchers said.
      Biologics, #RA and Risk of skin CA (NMSC) is complex.
      - RA alone is a risk for NMSC
      49K study of ABA & NMSC ;
      -

      Dr. John Cush RheumNow

      1 year 11 months ago
      Biologics, #RA and Risk of skin CA (NMSC) is complex. - RA alone is a risk for NMSC 49K study of ABA & NMSC ; - In RCTs, risk same w/ ABA & PBO - Registries & Claims data: equal w/ ABA, csDMARDs. b/tsDMARDs - Pooled obs data shows slight ABA risk https://t.co/tp6F0cJWug https://t.co/u6UdAUZqoc
      ACR QD Clinics - Neighbor Consults
      A study of nearly 80,000 US veterans who underwent primary knee joint arthroplasty (TKA) showed  the incidence of prosthetic joint infection (PJI) was highest in the first 3 months and remained elevated through 12 months compared with 12 months or more after surgery. Gram-negative organisms were more prevalent in early vs delayed or late PJIs.
      UK biobank population study shows a bidirectional assoc. betw RA & ILD (each @ incr risk for the other). In non-COP

      Dr. John Cush RheumNow

      1 year 11 months ago
      UK biobank population study shows a bidirectional assoc. betw RA & ILD (each @ incr risk for the other). In non-COPD pts, RA increased risk of COPD (HR=1.65) & in non-RA pts, COPD had a higher risk of future RA (HR=1.67). Both mediated by inflammation https://t.co/imn4ddV7CS https://t.co/UZaszEnCqt
      A prospective study of first line use anakinra in systemic juvenile idiopathic arthritis (sJIA) proved to be effective and without potentially allergic lung reactions.
      Oral Surveillance Study Alters Practice at VA

      Safety risks found in a postmarketing trial with the JAKi tofacitinib (X

      Dr. John Cush RheumNow

      1 year 11 months ago
      Oral Surveillance Study Alters Practice at VA Safety risks found in a postmarketing trial with the JAKi tofacitinib (Xeljanz) appear to have influenced prescribing patterns across the class for RA patients in the VA health system, researchers found. https://t.co/6WktHCkrI1 https://t.co/8wpAeLsBbw
      Metanalysis of 26 studies (2252) pts w/ HBsAg-/HBcAb+ RA treated with b/tsDMARDs, shows the pooled HBV reactivation rate

      Dr. John Cush RheumNow

      1 year 11 months ago
      Metanalysis of 26 studies (2252) pts w/ HBsAg-/HBcAb+ RA treated with b/tsDMARDs, shows the pooled HBV reactivation rate was 2.0% HBV reactivation higher w/ RTX (9%), ABA (6%), JAKi (1%); none w/ IL-6i or TNF-i More reactivation if pt is HBsAb- (OR=4.56) https://t.co/V60nkUSpjj https://t.co/jnZKnY0Zuk
      Study of LATE-onset RA (>65y), shows DMARD initiation is low in LORA; despite current clinical practice guidelines r

      Dr. John Cush RheumNow

      1 year 11 months ago
      Study of LATE-onset RA (>65y), shows DMARD initiation is low in LORA; despite current clinical practice guidelines recommending early aggressive Rx. Among 3,373 LORA pts (age77 yrs), only 29% initiated on a DMARD (28.9%). https://t.co/bWHaiiSMVl https://t.co/NmrDeG8UPW
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