Rheumatoid Arthritis

Dr. John Cush RheumNow
1 year 11 months ago
Retrospective study(2016-2019) of referred newly, suspected (#RA) pts found no value in initial Xrays. Only 32/724 patients (4.4%) had RA like erosions, with Erosions leading to a Dx in only 2 pts (0.3%) & changed prognostic classification in 3 pts (0.4%) https://t.co/fi48WiBgIc https://t.co/skObArXYr6

Research work from the Accelerating Medicines Partnership (AMP: RA/SLE) Network, was published in Nature and more specifically characterizes RA synovium into several cell-type abundance phenotypes (CTAPs). Could CTAPs known disease features or more effective future therapies?
A recent CDC reports estimates that in 2019–2021, 21% of U.S. adults (53.2 million) have physician diagnosed arthritis. Now, an updated report shows a larger number (~33%) of U.S. veterans having diagnosed arthritis. Compared to nonveterans, this prevalence was double in men, and 60% higher in women.

Dr. John Cush RheumNow
1 year 11 months ago
Patients Don't Read Textbooks
RA patient unresponsive to biologics, now has enthesitis; what to do?
QD Clinics are sponsored by RheumNows Coverage of #ACR23 live from San Diego
https://t.co/hlacYXm0Nh https://t.co/52Xy3E8kXi

The American College of Rheumatology's (ACR) has published a preview of new research from ACR Convergence 2023 showing that AI and a deep learning system could accurately identify and predict joint space narrowing and erosions in hand radiographs of patients with rheumatoid arthritis (RA).
Routine hand and foot radiographs in more than 700 patients being evaluated for rheumatoid arthritis (RA) made almost no difference in diagnosing the condition nor in predicting its course, Dutch researchers said.

Dr. John Cush RheumNow
1 year 11 months ago
Biologics, #RA and Risk of skin CA (NMSC) is complex.
- RA alone is a risk for NMSC
49K study of ABA & NMSC ;
- In RCTs, risk same w/ ABA & PBO
- Registries & Claims data: equal w/ ABA, csDMARDs. b/tsDMARDs
- Pooled obs data shows slight ABA risk https://t.co/tp6F0cJWug https://t.co/u6UdAUZqoc

A study of nearly 80,000 US veterans who underwent primary knee joint arthroplasty (TKA) showed the incidence of prosthetic joint infection (PJI) was highest in the first 3 months and remained elevated through 12 months compared with 12 months or more after surgery. Gram-negative organisms were more prevalent in early vs delayed or late PJIs.

Dr. John Cush RheumNow
1 year 11 months ago
UK biobank population study shows a bidirectional assoc. betw RA & ILD (each @ incr risk for the other). In non-COPD pts, RA increased risk of COPD (HR=1.65) & in non-RA pts, COPD had a higher risk of future RA (HR=1.67). Both mediated by inflammation https://t.co/imn4ddV7CS https://t.co/UZaszEnCqt

A prospective study of first line use anakinra in systemic juvenile idiopathic arthritis (sJIA) proved to be effective and without potentially allergic lung reactions.

Dr. John Cush RheumNow
1 year 11 months ago
New download available, titled "Dealing with Infections"
https://t.co/hsOuJoFokg https://t.co/G3MZ9BQo0X


Dr. John Cush RheumNow
1 year 11 months ago
Oral Surveillance Study Alters Practice at VA
Safety risks found in a postmarketing trial with the JAKi tofacitinib (Xeljanz) appear to have influenced prescribing patterns across the class for RA patients in the VA health system, researchers found.
https://t.co/6WktHCkrI1 https://t.co/8wpAeLsBbw


Dr. John Cush RheumNow
1 year 11 months ago
Metanalysis of 26 studies (2252) pts w/ HBsAg-/HBcAb+ RA treated with b/tsDMARDs, shows the pooled HBV reactivation rate was 2.0%
HBV reactivation higher w/ RTX (9%), ABA (6%), JAKi (1%); none w/ IL-6i or TNF-i
More reactivation if pt is HBsAb- (OR=4.56) https://t.co/V60nkUSpjj https://t.co/jnZKnY0Zuk


Dr. John Cush RheumNow
1 year 11 months ago
Study of LATE-onset RA (>65y), shows DMARD initiation is low in LORA; despite current clinical practice guidelines recommending early aggressive Rx. Among 3,373 LORA pts (age77 yrs), only 29% initiated on a DMARD (28.9%). https://t.co/bWHaiiSMVl https://t.co/NmrDeG8UPW
