Autoinflammatory
European Rheum Consortium (SHARE) recommendations for Rx of systemic JIA: 1) Systemic JIA - AOSD; 2) STEROIDs, 3) IL-1 inhibitors; 4) TCZ, 5) MTX & TNFi mainly for arthritis. Should be aware of risk for MAS and ILD #ACR20 Abstr#1148 https://t.co/mgZvLKNljs
Dr. Olga Petryna discusses two abstracts, abstract #1496 and #1149, presented at the ACR annual meeting. Abstracts available at www.acrabstracts.org.
@RheumNow #acr20 abs0098 CCL2&CCR2 may play role in inflammatory response in AOSD, high levels in active AOSD subside with six resolution. Correlate with CRP, neutrophil count& ferritin levels. Does not correlate w/ Clincial markers of disease activity
Interim analysis of the RELIANCE registry studying effect of canakinumab (CAN) in 80 patients w/ febrile CAPS. Efficacy of CAN assessed w/ AIDA (inflam index) showing ~70% were in low activity (<9) @ACR20 Abstr#1479 https://t.co/UC2eJbpVLM https://t.co/M71s8gXZY9
Dr. Petryna reviews several pegloticase-related abstracts presented at the ACR 2020 annual meeting, including abstracts #0683 and #0677.
NYU's Dr. Michael Pillinger promises deeper looks at ACR 2020 activity regarding gout, but starts out reporting data from GCAN.
Dr. Bella Mehta reviews abstract #0425 presented at the 2020 ACR annual meeting.