ARDs increase risk for CVE in pregnancy, the highest being APS, SLE (with LN and APS) and RA. Close monitoring not only during but also after pregnancy is required. #Plenary #ACR23 https://t.co/W3CSjccSno

Pregnant women with ARDs esp. SLE nephritis and primary APS have significantly higher risks for acute CVEs compared to those without these conditions. 25-30% of CVEs occurred during the postpartum period, Dhital R Abst#0722 #ACR23 #ACRBest @RheumNow https://t.co/m9FjsAu64N https://t.co/1dyTzgH97A

ACR 2023 Daily Recap - SUNDAY https://t.co/X9NNGLe78z

• Dr. John Cush

Urinary biomarkers precede loss of kidney fxn in LN by @andreafava #Ab0850 @RheumNow #ACR23 73 pts w LN. 44% devel GFR loss Elevation of urinary biomark of histo activity at 6, 12 mo predict GFR loss at 3 yrs - esp IL-16, >> proteinuria Combo biomark 12 mo: AUC 0.95 #ACRBest https://t.co/M7sfpCm7Kz

AI predict ANA specific Abs? @AliDuarteMD Ab#0852 #ACR23 @RheumNow 410K pts test for ANA HEp-2 IFA (136K pos, 47K specific autoAb) AI prediction models >0.80 AUC exc for RNP, Scl70 More predictive than traidtional staining patterns (p<0.001), except centromere (similar) https://t.co/4ZvP79rEdl

Results of this study by Dr Fava show that most urinary BMs of histological activity were⬆️at 6 & 12mos in pts who lost GFR at 3yrs. ☝️Some LN pts still develop renal damage despite clinical response. Is there a role for BMs in monitoring tx? #ACR23 ABST0850 @RheumNow #ACRbest https://t.co/H5G6LJ22lw

IFN 5-gene signature to ID high IFN subsets as biomarkfor DEUC in PAISLEY P2 SLE trial Ab847 #ACR23 @RheumNow IFN 5 gene score - 78% IFN-high pt IFN high ass w SLEDAI-2K, CLASI, PGA, dsDNA, low C3/C4/lmphocyte DEUC reduc IFN 5 gene score in both grps, best clin response in IFN hi https://t.co/WpZHE5z8za