Drug Safety

Richard Conway
1 year 10 months ago
Real world data on low dose PEXIVAS steroid by Nagle et al. Increased risk of progression/relapse/death/ESKD in those with severe GPA/MPA HR 1.72. More marked in those with creat>300 or with RTX induction Abstr#0725 #ACR23 @RheumNow https://t.co/vTXVZfjbXx https://t.co/4FuMjxOuyB


Dr. Antoni Chan
1 year 10 months ago
Higher disease activity and systemic inflammation at baseline associated with greater risk of MACE in bDMARD nonusers but not in users. bDMARD-specific benefits directly on MACE risk beyond reducing inflammation, Karpouzas et al Abst#0391 #ACR23 @RheumNow https://t.co/lfoccZffTW https://t.co/ASpKYQof1I


Meral K. El Ramahi, MD MeralElRamahiMD
1 year 10 months ago
YR in Review: Dr. Seo
🚩GLORIA Trial
RA pts > 65yo: prednisolone 5 mg/d x 2 yrs vs PBO + std care
➡️decr dz activity (DAS ⬇️0.37) but 24% incr ADE
🚩Extension:
➡️Tapered off pred over 3m and..
⭐️NO ADRENAL INSUFF
But, small incr in dz activity (DAS ⬆️0.23)
#ACR23 @RheumNow https://t.co/YQbS6C8ZT5


Mike Putman EBRheum
1 year 10 months ago
Yet another (mostly) reassuring report about lymphoma and DMARDS
The skin cancer signal in the CIRT trial was weird; would be worth looking into that in observational studies as well @NamrataRheum
#ACR23 Abst0438 @RheumNow https://t.co/Beg8UUe2mn


Meral K. El Ramahi, MD MeralElRamahiMD
1 year 10 months ago
Year in Review by Dr. P Seo
NORD-STAR trial:
⭐️Abatacept or Certolizumab >> Tociluzumab > triple therapy in tx of 812 early RA patients based on clinical & radiographic results
➡️tx-naive, all got MTX
➡️mod-sev dz activity
➡️randomized to 48 wks therapy
#ACR23 @RheumNow https://t.co/vy2uYuyOse


Mike Putman EBRheum
1 year 10 months ago
Interesting question... but feels like some time related bias or perhaps confounding?
Seems implausible that MTX & biologic would be protective for PsO & harmful for PsA
@RheumNow #ACR23 Abstr 0498 https://t.co/pSRoLHRTAm


Mike Putman EBRheum
1 year 10 months ago
Nice VA study evaluating risk of lung cancer w/respect to RA treatment strategies
Take home? No association. Aside from the (small risk) w/JAKi's, I think malignancy risks have been mostly overblown
@NamrataRheum @RheumNow ABST0453 #ACR23 https://t.co/lDz0nV1KHt


Dr. Rachel Tate
1 year 10 months ago
PEXIVAS results: the reduced-dose GC regimen associated w/ ^ death, ESRD, and uncontrolled dz risk in severe GPA/MPA pts. Even greater risk in pts w/ creatinine levels > 300 μmol/L & in those tx w/ RTX induction. #ACR23 Plenary 0725 https://t.co/mBMrEaGj5k @rheumnow https://t.co/flAfYEKSXJ

Of the many exciting advancements for patients with psoriatic arthritis at ACR Convergence, one upcoming therapy stood out: the dual IL-17A/F inhibitor bimekizumab. Nearly two dozen bimekizumab abstracts will be featured at this year’s meeting and it recently received authorization in Europe and the U.S. for psoriasis. That makes this the year I plan to figure out where this drug will be useful for my patients with PsA.
For over 70 years, glucocorticoids, (GC) have been a part of standard therapy in SLE. They are classically used to not only induce remission or treat an acute flare, but also as maintenance therapy. They are a valuable 'friend' if used wisely, and can become a 'foe' if used excessively.

Dr. John Cush RheumNow
1 year 10 months ago
Join us tonight at 6pm PT/ 9pm ET for our daily #ACR23 recap. https://t.co/0RDwTdzhwS


Bella Mehta bella_mehta
1 year 10 months ago
Little disturbing to see the data that most patients using cannabis dont know what exact product they are using. Also not most is not prescribed/ illegal!
Lots to learn and may have potential but need to be careful!
@RheumNow #ACR23 https://t.co/Y0vHmVvWdL


Bella Mehta bella_mehta
1 year 10 months ago
Controlled substance rundown - CBD and THC are the key molecules
Used since 5K years
18 percent of americans have used opiods once since 2019!
@rheumnow #ACR23 https://t.co/iEscYxB5j5


Mike Putman EBRheum
1 year 10 months ago
FAST trial, MMF vs MTX at the Review Course today
Overall a big win for MTX, powered for noninferiority (bc people loved MMF) but looks like MTX won the day w/10% difference in outcomes
Take home: MTX FTW per usual
@RheumNow #ACR23 #ReviewCourse https://t.co/lY1V6S7X3d
