Rheumatoid Arthritis
Dr. Antoni Chan
1 year 10 months ago
No significant difference in overall survival in early stage breast cancer (BC) patients treated with TNFi (alone -/+ cDMARDs, in 1st year of BC) and cDMARDs in RA. Those on glucocorticoids had worse survival. Suarez-Almazor M, Abst#1675 #ACR23 @RheumNow https://t.co/lnZx3OpuN5
Aurelie Najm
1 year 10 months ago
Insights into pathogenesis venous & arterial thrombosis in RA + JAKi
Significant dysregulation of clotting pathways in myeloid & increased clot formation in context of microbial challenge (TLR4)
Observed across all JAKI, but selective JAK3i
@RheumNow #ACR23 ABST1676 https://t.co/nboy0znfAW
Methotrexate is widely used in rheumatic diseases yet poses common tolerance issues, especially for the oral form; and bioavailability is known to be limited for doses over 15mg. In the SMART study, Prasad et al. present the first RCT comparing either single dose (25 mg) or split-dose (10 mg morning, 15 mg evening, same day) once weekly MTX for 24 weeks.
David Liew drdavidliew
1 year 10 months ago
Hand movement video: more promising than photos as a computer vision concept for remote monitoring of RA disease activity.
Of course: validation, training, clinical evaluation all must happen before it is ready for your clinic
https://t.co/HyN6ElKF0F #ACR23 ABST1293 @RheumNow https://t.co/DltI9HFiFE
Aurelie Najm
1 year 10 months ago
Fatigue 😴 in RA & synovial biology
In DAS LDA pts Fatigue asso w/
-female sex
-synovial lymphocytic inflammation
In DAS moderate DA:
-female sex
-synovial lining layer
-Anxiety
Limitations: arthroplasty tissue, small sample size, no Immunohisto
@RheumNow #ACR23 ABST1630 https://t.co/4vhzvdPgyd
Richard Conway
1 year 10 months ago
Fisher et al. In high disease activity, fatigue associates anxiety and synovial lining hyperplasia, 1.57[1.01,2.5]; p=0.047) In LDA, fatigue associates chronic lymphocytic synovial inflammation, 1.92[1.09,3.57]; p=0.024) Abstr#1630 #ACR23 @RheumNow https://t.co/Gev6pU3srq https://t.co/Ys8etP36ir
David Liew drdavidliew
1 year 10 months ago
Do we miss RA activity in obese pts?
Pre-clinical trial entry MSK USS:
similar DAS28
but lower SJC/US scores in obese
Is it because, in obese RA patients:
we underdetect on exam?
we undertreat?
higher risk, so lower penetrance of severe dx endotypes?
#ACR23 ABST1287 @RheumNow https://t.co/3FFPdBJOpz
Bella Mehta bella_mehta
1 year 10 months ago
Multimorbidity in #RA - VARA registry data- looking at 61 different biomarkers and 44 comorbidities
Chronic pain in 44%
Specific biomarkers seen in different morbidities
@rheumnow #ACR23 session#13M148 https://t.co/l6FU1ELKD3
Aurelie Najm
1 year 10 months ago
Peyton et al.: 4 multimorbidity patterns in RA
-Mental health and subst abuse
-Metabolic
-CV
-Chronic pain
All associated with different sets of biomarkers.
Some are very specific of one profile while others are widespread across profiles.
@RheumNow #ACR23 ABST1631 https://t.co/VqCrLI3oyy
Dr. Antoni Chan
1 year 10 months ago
In PS-matched study, no significant difference in respiratory hospitalisation or death between RA-ILD patients on non-TNFi/JAKi vs. TNFi. This finding does not support systematic avoidance of TNFi in RA-ILD, England B Abst#1582 #ACR23 #ACRBest @RheumNow https://t.co/1zVjMWNZZS https://t.co/d8TRIvGaIe
TheDaoIndex KDAO2011
1 year 10 months ago
Abst#1583 SMART study: Split dose qwk MTX (10 mg QAM, 15 mg QPM) may have better efficacy compared to 25 mg single dose qwk MTX. RCT 253 RA patients: split dose had better DAS score, less likely to add other DMARDS, but slight⬆️in LFTs. #Plenary #ACR23 @rheumnow #ACRbest
TheDaoIndex KDAO2011
1 year 10 months ago
It's OK to use TNFi in RA-ILD!
VA study 1000+ pts using Target Trial Emulation framework: TNFi vs nonTNFi biologics/JAKi followed for 3 years. NO differences in respiratory hospitalizations or deaths or all cause mortality. abst#1582 #ACR23 #ACRbest @rheumnow https://t.co/aI2SmMrLPE
Poster Hall