Autoinflammatory
Dr. John Cush RheumNow
3 years 1 month ago
Seminal Articles on Stills disease Tues Nite Rheum Journal Club tommorrow
Discussants: Drs. Bella Mehta, Michael Weisman & Jack Cush
7pm EDT (4pmPDT) - The 1st articles on AOSD from Bywaters & Bujak https://t.co/yRgHlmZHhi
https://t.co/ooexkgM6ga
Register: https://t.co/kstge3gAcl https://t.co/XjQJi4FRmt
Dr. John Cush RheumNow
3 years 1 month ago
Study of 50 #AOSD pts refractory to steroids (n=11), DMARDs (34) & biologics (n 30): given canakinumab 150–300 mg q 4wk (47) or q8wk(3). W/ 27 mos F/U: 78% complete resp w/in 3 mos (20% partial). Steroid sparing in 1/2, Low WBC 6%, 4%SIE https://t.co/QMCLictdrL https://t.co/5hkUOBFDG0
Dr. John Cush RheumNow
3 years 1 month ago
Myths & Misconceptions with Febrile Disorders
Dr. Rachel Tate ( @uptotate) weighs on the myths and misconceptions with Still's disease and autoinflammatory disorders.
https://t.co/z0KHbxnLjJ https://t.co/ymsXYDP5Zs
Dr. John Cush RheumNow
3 years 1 month ago
QD Clinic - Stills (or Not); A Wife's Letter
A letter from the wife of a hospitalized febrile patient says it all.
But, is this Still's disease or not?
https://t.co/MpPbDU9ZTB https://t.co/BqpusOKKLq
Dr. John Cush RheumNow
3 years 1 month ago
Still’s Disease FAQs
What is the classic 'triad' of Still's disease? Does it affect males and females equally? What are typical lab findings? Which drugs are effective at treating Still's, and which ones are not? What about complications? Read on...
https://t.co/rsFHNPwo9Y https://t.co/AUP1GpbDaN
Many clinicians may not have seen a case of AOSD during training, which overall leads to several delays in referrals and appropriate diagnosis for AOSD patients. AOSD is an autoinflammatory disease where innate immunity plays a primary role and is characterized by seemingly unprovoked inflammation, but without the high-titer autoantibodies or antigen specific T cells seen in autoimmune diseases.
Dr. John Cush RheumNow
3 years 2 months ago
New download available! We're providing an introduction to Still's Disease.
https://t.co/67XzncaUef https://t.co/gaMNGk0grn
Dr. John Cush RheumNow
3 years 2 months ago
Proposed investigations (findings) in the diagnosis of Stills disease: - CRP, ESR, Ferritin (high) - W/U for infection, cancer (negative) - Serologies (negative) - consider Imaging (CXR, CT, US, PET) https://t.co/ByNSq8YACC https://t.co/BdhfRjPA6L
Dr. John Cush RheumNow
3 years 2 months ago
MRP8/14 as a Biomarker in Systemic Juvenile Idiopathic Arthritis
A large cohort study of children with febrile disorders has demonstrated the diagnostic utility of MRP8/14 in diagnosing systemic JIA patients (SJIA) in clinical practice.
https://t.co/Gma3h9Iuqn https://t.co/7GOeES4bbA
Dr. Jack Cush reviews the new studies and drug approvals and new insights into febrile disorders from the past week on RheumNow.com
Ustekinumab (IL-12/23i) phase 2 study was successful in #SLE; but the phase 3 LOTUS study of 512 pts, UST was NOT superior to PBO (SRI-4 44% v 56%) at 1 year. Study was halted for lack of efficacy (but no safety concerns). https://bit.ly/3RvPzDm
Dr. John Cush RheumNow
3 years 2 months ago
QD Clinic - Stills (or Not) with Hives
What do you think? 40 yr. woman with fevers, hives, and LFTs.
https://t.co/IZNnWzerOL https://t.co/sUGPuy2tKC
Dr. John Cush RheumNow
3 years 2 months ago
NEJM Case - 17-Year-Old Girl with Fever and Cough and B/L lower lobe infiltrates. 3 wk hx started w/ conjunctivitis, SOB, Cough fever myalgia & knee pain. No rash. T 38.5°C, W 11.5, H/H 6.9/21, P526k, CRP 77mg/L, UA 2+ protein, neg COVID tests. https://t.co/VOiW7DIdBR https://t.co/1GWA2gAgeK
Poster Hall